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There is little epidemiological data on heart failure (HF) in the younger age groups dominating clinical HF trials. We assessed gender-specific long-term HF incidence and mortality in an urban community-based sample of middle-aged subjects. Between 1974 and 1992, 33,342 HF-free subjects (10,900 [32.7%] women, mean age 45.7 +/- 7.4 years) were included in the Malmö Preventive Project, on average 21
Increased mortality risks associated with smoking are well established among men. There are very few population-based studies comprising a sufficient number of heavily smoking women, measuring the direct effect of smoking on mortality risks. Between 1974 and 1992, 8,499 women and 13,888 men attended a health screening programme including reporting of smoking habits. Individuals were followed for t
BACKGROUND: It is generally argued that variations in cerebral blood flow create concomitant changes in the cerebral blood volume (CBV). Because nitrous oxide (N(2)O) inhalation both increases cerebral blood flow and may increase intracranial pressure, it is reasonable to assume that N(2)O acts as a general vasodilatator in cerebral vessels both on the arterial and on the venous side. The aim of t
OBJECTIVES: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J mice and such mice rendered glucose-intolerant and insulin-resistant by feeding a high-fat diet. DESIGN: In mice
Background Calcipotriol and betamethasone dipropionate are both widely used, effective treatments for psoriasis. Vitamin D analogues and topical corticosteroids have different mechanisms of action in the treatment of psoriasis. A new vehicle has been developed in order to contain both calcipotriol (50 micro g g-1) and betamethasone dipropionate (0.5 mg g-1) in an ointment form. By using calcipotri
Objective: Non-obese patients with type 2 diabetes (T2DM) are characterized by predominant defective insulin secretion. However, in non-obese T2DM patients, metformin, targeting insulin resistance. is non-inferior to the prandial insulin secretagogue, repaglinide, controlling overall glycaemia (HbA(1c)). Whether the same apply for postprandial glucose and lipid metabolism is unknown. Here. we comp
Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability and bioactivity. We aimed to examine the association between individual flavanol and flavonol intakes and risk of developing T2D across European countries. The European Prospec
Degenerative changes of the lumbar spine may lead to misinterpretation of bone mineral density (BMD) measurements and cause underdiagnosis of osteoporosis. This longitudinal study of 1,044 women, 75 years at inclusion and followed for 10 years, shows that identification of apparent degenerative changes on the dual energy X-ray absorptiometry (DXA) scan can increase the proportion diagnosed. INTR
ObjectiveTo examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE). MethodsA disease inception cohort was assessed annually for headache (5 types) and 18 other neuropsychiatric (NP) events. Global disease activity scores (SLE Disease Activity Index 2000
PURPOSE: Several studies have indicated that broad genomic characterization of childhood cancer provides diagnostically and/or therapeutically relevant information in selected high-risk cases. However, the extent to which such characterization offers clinically actionable data in a prospective broadly inclusive setting remains largely unexplored.METHODS: We implemented prospective whole-genome seq
This open access book contributes to ongoing discussions about how societies should respond to children who have experienced violence and abuse by delving into the Barnahus model: a multidisciplinary and co-located model whose aim is to provide both justice and recovery to victimised children. The promising model was first implemented in the Nordic region and is currently being diffused across Eur
Background and purpose: Tamoxifen remains an important adjuvant treatment in premenopausal patients with hormone receptor-positive breast cancer. Thus, determination of hormone receptors is important. Here, we compare cytosol-based methods, immunohistochemistry (IHC), and gene expression (GEX) analysis for determining hormone receptor status in premenopausal breast cancer patients from a randomise
Background: Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia. Methods: We conducted a prospective study with 403,506 partici
1 Överenskommelse om Bestämmelser för arbetstagare i arbetsmarknadspolitiska insatser – BEA Parter Sveriges Kommuner och Regioner och Sobona – Kommunala företagens arbetsgivarorganisation å ena sidan, samt Svenska Kommunalarbetareförbundet å den andra. § 1 Innehåll m.m. Parterna träffar detta kollektivavtal Bestämmelser för arbetstagare i arbetsmarknadspolitiska insatser, BEA 25. Till avtalet hör
Microsoft Word - nyhetsbrev_02.docx Nyhetsbrev från Akademikerföreningen Sveriges Ingenjörer vid Siemens Energy AB Kontakt: asi.se@siemens-energy.com Redaktörer: CH, JH, SvE Nr: 03/22 2022-11-10 VOLT Den 25:e maj lanserades den nya organisationen, VOLT, på det globala intranätet – myEnergy Hub. Där presenterades den tilltänka funktionella organisationen ner till lägsta hierarkiska nivå. Lanseringe
Artificiell intelligens får ett allt större utrymme i den allmänna debatten och dess användningsområde växer hela tiden. Ett användningsområde som blivit allt är Kreativ AI. Kreativ AI syftar till att återskapa den mänskliga kreativiteten genom att skapa konstnärliga och litterära alster. Denna uppsats syftar till att belysa och besvara några av de centrala upphovsrättsliga utmaningarna och frågesArtificial intelligence is gaining more and more room in the public debate, and its field of application is constantly growing. One area of use that has become bigger is computational creativity. Computational creativity aims to recreate human creativity by creating artistic and literary works. This essay aims to highlight and answer some of the vital copyright challenges and issues posed by Compu
The purpose of this study is to explore the opportunities and challenges for self-employed artists who use social media for their business. The research is focused on painters and illustrators who have digitalised and commercialised their own artwork. The method follows a qualitative research framework with a comparative design of multiple cases on the level of individual artists. Seven artists fr
The undrained shear strength of cohesive soils is an important parameter to assess in geotechnical investigations. It is normally evaluated with the cone penetration test (CPT) but problems with penetrating coarse, heterogeneous materials that is also hard, such as clay till, have pointed the interest towards other possible in-situ methods. This has led to studies assessing the possibility to eval
Despite Sweden having implemented strict laws against child abuse and adopting the Convention on the Rights of the Child into law, child abuse remains a significant societal issue. Although it is clear that legal changes play a role in strengthening the protection and rights of children, legislation and actual circumstances do not always align. This study aimed to highlight different experiences o
