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Purpose: We measured concentrations of human glandular kallikrein 2 (hK2), total prostate specific antigen (tPSA), free PSA (fPSA) and percent fPSA to evaluate their relationship to total prostate gland volume, benign prostatic hyperplasia (BPH) volume, total prostate cancer (PCa) volume (CaVol) and the volume of Gleason grades 4/5 cancer (CaVolG14) in the serum of 256 patients with PCa undergoing
Importance: Prenatal diagnosis of complex congenital heart defects reduces mortality and morbidity in affected infants. However, fetal echocardiography can be limited by poor acoustic windows, and there is a need for improved diagnostic methods.Objective: To assess the clinical utility of fetal cardiovascular magnetic resonance imaging in cases in which fetal echocardiography could not visualize a
Objective: To identify factors affecting the outcome after open surgical (OSR) and endovascular (ER) repair of popliteal artery aneurysm (PA) in comparable cohorts. Methods: A matched comparison in a national, population based cohort of 592 legs treated for PA (2008 – 2012), with long term follow up. Registry data from 899 PA patients treated in 2014 – 2018 were analysed for time trends. The 77 le
Objective: To investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations. Methods: Patients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nucleotide polymorphisms (SNP) Array (Illumina) and a custom array. Sixty SNPs with SLE association (p<5.0×10-8) were analysed. Signal transducer an
This paper revises the design process for closed-loop combustion control based on in-cycle feedback. Methods for the necessary observers, detectors and virtual sensors are also discussed. The control problem tackles the indicated efficiency optimization, following two approaches, direct and indirect optimization. The argumentation provides a comprehensive overview on how to specify and integrate d
Background: A novel data-driven classification of type 2 diabetes has been proposed to personalise anti-diabetic treatment according to phenotype. One subgroup, severe insulin-resistant diabetes (SIRD), is characterised by mild hyperglycaemia but marked hyperinsulinaemia, and presents an increased risk of diabetic nephropathy. We hypothesised that patients with SIRD could particularly benefit from
En ökad mångfald kan leda till att religiösa frågor i arbetslivet får en ökad aktualitet och att en individs rättigheter och krav då ställs mot arbetsgivarens verksamhetsintresse och dennes rätt att leda och fördela arbetet. En arbetstagares vägran att utföra en viss arbetsuppgift på grund av religion eller samvete måste då vägas mot arbetsgivarens arbetsledningsrätt och andra eventuellt motståendAn increased diversity in the work force has caused religious questions to become increasingly important and this may lead to a conflict between an individual’s rights and demands and the employers’ managerial prerogative. An employee’s refusal to perform a duty, based on religious or conscientious beliefs, must then be weighed against the employer’s managerial rights and other possible conflictin
Authors: Emma Nilsson and Emma Silverberg Title: People in a crisis are not able to work with change Supervisor: Helene Hansen Assessor: Mikael Sandgren The aim of this study was to examine social workers reasoning on social services support to parents of children placed in compulsory care. This study was based on the Swedish social services law, 6:7 Socialtjänstlagen, that describes that parents
This study aims to investigate the possibility of creating template times for rail works. Furthermore the study identifies a few effects which template times could have on planning of rail works, traffic and economy. Template times are being considered by the Swedish Transport Administration, Trafikverket, for the early stages of planning when there is a need to estimate the time required within t
The focus of this thesis is the myths and ideologies inscribed into the aesthetics, narratives and gameplay of post-apocalyptic videogames. The aim is to discuss how the conditions and conventions of the game medium shape what is presented to us as a modern, secular form of apocalypticism. The case studies presented are the two well-known videogames Fallout 4 and The Last Of Us. The research focus
The Danish and Swedish Promissory Notes Acts were developed in a joint Nordic cooperation with the explicit ambition to create a uniform legislation regarding promissory notes. Neverthe-less, the conflict between negotiability on the one hand and minors' legal incompetence on the other hand is resolved differently in the Danish and Swedish Promissory Notes Acts, Sections 14 and 19. Danish law
Executive compensation is one of the most widely discussed topics since the latest economic turmoil. Shortly after the S&P 500 decreased by almost 50 percent in fall 2008, 70 percent of the 200 largest corporations in the United States reported changes in compensation packages for their executives. This study gives the reader an empirical insight into the stock market reaction following the an
Koppar-guld fyndigheten Nautanen är belägen 75 km norr om polcirkeln, och 10 km nordost om Gällivare i norra Sverige. Fyndigheten ligger endast 8 km från den stora apatit-järnmalmen i Malmberget och 15 km norr om en av Europas största kopparproducenter, porfyrkoppar-(guld)malmen Aitik. Nautanen beskrivs som en järnoxid-koppar-guld (IOCG) fyndighet eller en hybrid IOCG med en kärna av höghaltiga reThe Nautanen Cu-Au deposit is located 75 km north of the Arctic circle, and 10 km northeast of the town of Gällivare in northern Sweden. Nautanen is just 8 km west of the giant Malmberget apatite-iron ore deposit and 15 km north of one of Europe’s largest copper producers, the Aitik Cu (Au) porphyry deposit. Nautanen is described as an Iron Oxide Copper Gold (IOCG) deposit or hybrid IOCG and conta
Apart from the substantive public procurement rules, harmonising national provisions for the award of public contracts, the Community also strives to ensure compliance with those rules. For that purposes the Remedies Directive 89/665/EEC has been adopted to ensure that effective and rapid remedies are available to aggrieved bidders. This directive has recently been amended by Directive 2007/66/EC
The regulation of the European parliament and the Council (EG) nr. 864/2007 on the law applicable to non-contractual obligations is known as Rome II. Rome II contains a conflict rule in art. 7 which determines the law applicable to a claim involving environmental damages connected with more than one state. This conflict rule does not only apply to cases of damage to property and persons, but also
Jag har i detta arbete tagit fram en metod för att mäta mängden fett i muskelceller som vare sig kräver vävnadsprover eller nålstick. Metoden ger också en bild av fettfördelningen i vävnaden. Detta kan vara mycket användbart vid utveckling av läkemedel, men också vid diabetes- och fetmaforskning. Muskelceller innehåller ett bränsleförråd i form av en droppe fett. För diabetespatienter och som en b"Introduction Cardiac steatosis, or overstorage of fat in the cardiac muscle cells, is a possible side effect from drugs treating diabetes mellitus. Therefore, a non-invasive means of fat quantification is needed during drug development. The aim of this master thesis is to develop a method to quantify the fraction intra-myocellular fat in the cardiac muscle of rats using magnetic resonance im
