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The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November 30-December 1, 2023. This reference congress served as a platform for in-depth discussions and exchange on recently completed outcomes trials including dapagliflozin (DAPA-MI), semaglutide (SELECT and STEP-HFpEF) and bempedoic acid (CLEAR Outcomes), and the
RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the "stringent" response and regulator of cellular metabolism. The classical "long" RSHs Rel, RelA and SpoT with the ppGpp hydrolase, synthetase, TGS and ACT domain architecture
AIMS : Transcatheter aortic valve implantation (TAVI), now a common procedure to treat high-risk patients with severe aortic stenosis, has rapidly been expanding into younger and lower-risk populations, creating a need to better understand long-term outcome after TAVI. The aim of the present investigation was to determine the incidence, risk factors for, clinical presentation of, and outcome after
This work presents an analysis of the physical properties of sub-micrometer aerosol particles measured at the high Arctic site Villum Research Station, Station Nord (VRS), northeast Greenland, between July 2010 and February 2013. The study focuses on particle number concentrations, particle number size distributions and the occurrence of new particle formation (NPF) events and their seasonality in
Introduction: An impact of maternal obesity on ultrasound dating of pregnancy at 11–14 gestational weeks is possible and was investigated. Material and methods: A prospective cohort study based on the Danish national population during a 4-year period in which we entered all mothers with singleton pregnancies who had a known last menstrual period (LMP), a recorded booking of body mass index (BMI),
Environmental impacts from passenger transportation continue to increase globally due to a rise in kilometers traveled and a shift to emission-intensive transportation modes (from public transportation and active modes such as walking and cycling to motorcycle and car ridership). The electrification of the passenger fleet, coupled with low-carbon energy sources, is expected to decrease some of the
BACKGROUND: Segmenting the whole-body somatostatin receptor-expressing tumour volume (SRETVwb) on positron emission tomography/computed tomography (PET/CT) images is highly time-consuming but has shown value as an independent prognostic factor for survival. An automatic method to measure SRETVwb could improve disease status assessment and provide a tool for prognostication. This study aimed to dev
Background: The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with Lu-177-[DOTA(0), Tyr(3)]-octreotate (Lu-177-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each patient as high amount of Lu-177-octreotate as possible, there is a need for methods/
BackgroundIncidence of condyloma, or genital warts (GW), is the earliest possible disease outcome to measure when assessing the effectiveness of human papillomavirus (HPV) vaccination strategies. Efficacy trials that follow prespecified inclusion and exclusion criteria may not be fully generalizable to real-life HPV vaccination programs, which target a broader segment of the population. We assesse
Abstract in Finnish Arvioinnin kohteena oli vuosien 2008–2011 ja 2012–2015 aikana toteutettu pitkäaikaisasunnottomuuden vähentämisohjelmakokonaisuus, Paavo I ja Paavo II. Arvioinnissa keskityttiin ohjelmakokonaisuuteen ja sen eri osa-alueisiin näkökulmana asunto ensin -mallin toteuttaminen suomalaisessa yhteiskunnassa. Arviointiraportissa on kuvattu Iso-Britannian, Ruotsin ja USA:n asunnottomuustyThe review covered the whole of the programme to reduce long-term homelessness implemented during 2008–2011 and 2012–2015, Paavo I and Paavo II. The review focused on the programme as a whole as well as its different aspects from the point of view of implementing the Housing First model in Finnish society. The review report described work on homelessness done in the United Kingdom, Sweden and the
Morphologic evaluation of samples from fine-needle aspiration (FNA) and core needle (CN) biopsies is an important part of the pretreatment diagnosis of bone and soft tissue tumors. Because most such tumors have characteristic, sometimes even specific, chromosomal rearrangements, ancillary genetic analyses could provide important diagnostic information. Whereas directed analyses, such as fluorescen
Popular Abstract in Swedish De två vanligaste typerna av neurodegenerativ demenssjukdom är Alzheimer’s sjukdom och Lewy body demens. Båda sjukdomarna drabbar framförallt äldre människor och risken att insjukna ökar med stigande ålder. Detta innebär att demenssjukdom kommer att bli vanligare i samhället, eftersom vi blir allt äldre och andelen invånare >65 år blir allt större. Att drabbas av demensBackground: A prognostic marker should provide information about course and outcome of disease, e.g. predict time to a given endpoint or rate of progression due to disease in patients or subgroups of patients. Prognostic markers could be targeted to apply during the entire clinical course or just during distinct stages of the disease. Aim: The aim of this thesis is to identify, review and qualif
Swedish R&D activities in the field of IT and the environment - a mapping related to indirect environmental effects and effects at system level Feb 2009: Peter Arnfalk, Andrius Plepys, Chris van Rossem, The International Institute for Industrial Environmental Economics, Lund University. The International Institute for Industrial Environmental Economics (IIIEE) at Lund University has, in autumn
Since 2007, Intelligent Energy (IE) has been involved in developing technologies and services in the hydrogen generation space with E.ON Gas Sverige AB and Swedish Gas Centre. The aim of this work is to support the development of a high-profile demonstration of hydrogen generation technologies in a Swedish context. The overall objective of the demonstration is to deploy a reforming based hydrogen
We used long-term monitoring data to assess causes behind a recent shift front a clear to a turbid water state in Lake Takern, Sweden. The lake has a previous record of shifts between clear-water and turbid states. but the causes behind these shifts are not well known. During the recent shift, which occurred in 1995-1997, Submerged vegetation Subsequently declined after a 30-year period of clear-w
Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 ca
Introduction: Monitoring replacement therapy with standard and extended half-life (EHL) products is challenging, since one-stage assay (OSA) and chromogenic substrate assay (CSA) results may differ significantly. Recent recommendations include local validation of each new product with recovery within 20–30%, depending on activity level. Aim: To validate factor VIII (FVIII) activity for monitoring
Hur påverkar anti-TSLP cellkommunikation och inflammation i lungan? Astma är en kronisk andningssjukdom som påverkar miljontals människor runt om i världen. Sjukdomen kännetecknas av luftvägsinflammation, överkänslighet och obstruktion, vilket leder till symtom som väsande andning, andnöd och hosta. Ny forskning visar att läkemedlet Tezepelumab, ett anti-TSLP läkemedel som blockerar TSLP, kan minBackground: Asthma, a prevalent chronic lung disease, affecting millions worldwide, is characterised by airway inflammation and increased smooth muscle mass and constriction, leading to the narrowing of the airway walls. Recent biologics have emerged as promising treatments for asthma. This study focuses on Tezepelumab, a monoclonal antibody targeting TSLP, which has been shown to improve airway h
