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Background - Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results - Five pa
Background: Smoking is probably the most important among preventable health risks. Health economic evaluation of smoking-cessation interventions, applying a lifetime perspective, is made possible by available epidemiological knowledge. The well established method of performing cost-effectiveness analyses of smoking-cessation interventions involves mathematical modelling (both deterministic and sto
Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
This work presents an on-chip memory subsystem envisioned for real-time applications performing Oriented FAST and Rotated Brief (ORB) feature extraction for Simultaneous Localization and Mapping (SLAM) systems. For autonomous navigation of battery-powered devices, feature-based SLAM is a computationally frugal alternative to direct methods. This paper thoroughly analyses ORB multiple memory access
AbstractBackground: Non-communicable diseases are the number one killer worldwide and the leading one,cardiovascular disease (CVD), is responsible for more than 30% of all deaths. CVD is a progressive disease whichalso makes it economical, easy and effective to prevent. There are many stages of CVD that ultimately can lead tocoronary atherosclerosis, measurable as coronary artery calcification (CA
An electron transfer mediator, 8-dimethylamino-2,3-benzophenoxazine (Meldola Blue), dissolved in the carrier solution in a flow-injection system, was found to reduce the oxidation potential for hydrogen peroxide from 600-1200 mV without mediator to - 100 mV vs. Ag/AgCl with the mediator present. The very low background current of reticulated vitreous carbon (RVC) at this potential makes it possibl
The thesis work concerns development and application of four versatile nonlinear optical techniques, based on exploiting ultrashort laser pulses, for diagnostic purposes in gases and flames. The four techniques, all laser-based, are two-photon laser-induced fluorescence (TPLIF), hybrid femtosecond/nanosecond (fs/ns) rotational coherent anti-Stokes Raman scattering (fs/ns RCARS), fs-laser-induced g
Spatial transcriptomics allows for the measurement of RNA abundance at a high spatial resolution, making it possible to systematically link the morphology of cellular neighbourhoods and spatially localized gene expression. Here, we report the development of a deep learning algorithm for the prediction of local gene expression from haematoxylin-and-eosin-stained histopathology images using a new da
Popular Abstract in Swedish Hur gick det till när det svenska riket expanderade norrut och införlivade Hälsingland? Denna bok är uppställd som en generalhypotes över denna långt utdragna process, som tar sin utgångspunkt i den samhälleliga kollaps som är skönjbar under 500-talet. De inhemska maktstrukturer som gradvis byggdes upp efteråt kom under medeltidens inledande århundraden att få känna på In which way did the power structures of central Sweden expand into the territories north of the forest Ödmården during the Middle Ages? This text reads like a general hypothesis for this process, which attempts to incorporate all relevant elements in the Medieval landscape of power. The study area chosen is the province of Hälsingland. The chronological take-off is the 6th century AD, when settle
An anthropomorphic phantom study was carried out in 2013-14 in two hospitals, one located in Russia (Mariinsky Hospital, Saint Petersburg) and the other in Sweden (Skåne University Hospital, Malmö). The aim of the study was to investigate the possibilities to reduce the patient dose from digital X-ray chest screening examinations. The existing chest imaging protocols were adjusted by changing the
It is challenging for the food industry to deliver products that satisfy consumers changing desires and needs. Baobab is a fruit that holds potential for the development of trendy food products due to its rich nutritional profile and unique rheology. Unlike most fruits, it contains a dry pulp with a moisture content of 11-12 % (Phytotrade, 2008). Despite these features, baobab has been overlooked
Elektromagnetiska vågor, även kända som radiovågor, är vågor som sprider sig med låga frekvenser från 3 till 30 kHz. Dessa lågfrekventa vågor används vanligtvis när man önskar kommunicera med ubåtar. De kan emellertid också användas på land för att mäta skillnader i jord– och bergarters elektriska konduktivitet. Denna mätteknik kallas Very-Low-Frequency Electromagnetics (VLF-EM) och har framgångsrElectromagnetic waves, also known as radio waves, which propagate at low frequencies of only 3 kHz to 30 kHz, are usually used for communication with submarines. However, these waves can also be used on land to measure differences in the electrical conductivity of the subsurface. This technique is called Very-Low-Frequency Electromagnetics (VLF-EM) and has been successfully used to gain an insight
Denna uppsats behandlar frågeställningar rörande romska barn, dvs. barn med minoritetsstatus i LVU-ärenden (lagen om vård av unga). Uppsatsens syfte är att studera hur rättsväsendet hanterar LVU-ärenden som berör romska barn och att undersöka om rättsväsendet vidtar speciella åtgärder för att garantera de romska barnen sina minoritetsrättigheter. Uppsatsens har även två delysften, att kortfattat bThis essay deals with issues concerning the Romani children, i.e. children with minority status in LVU cases (the law on the care of youth). The essays main purpose is to study how the legal system handles LVU cases involving Romani children and to investigate if the judiciary is taking special measures to ensure the Romani children their minority rights. The essay also aims to briefly describe th
FooBadges is an initiative by Foo Café where the vision is to increase the participation in events at Foo Café and reduce the number of people who choose not to attend an event they have signed up for. To increase the participation in events at Foo Café and reduce the number of people who sign up for an event but choose not to attend, a proposal for an Open Badge-system should be presented. An Ope
In 1996, Robert A. Haugen and Nardin L. Baker published a study where they had made a multi-factor model based on micro-variables on the American stock market between 1979 and 1993. In testing the model on the examined period they made an average annual return of 30,9 percent. They also tested the model on several other markets around the world with similar results. This study is a somewhat simple
Background: Routine oxygen therapy has for a long time been used as part of the standard treatment for myocardial infarction (MI), despite a lack of randomized controlled trials (RCT) to support the use. A recent Cochrane review on oxygen treatment for normoxic MI patients found no evidence supporting the use, rather the trend pointed towards possible harm for oxygen. The SOCCER-study (Supplementa
