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Background: Myocardium at risk (MaR) can be evaluated by cardiovascular magnetic resonance (CMR) imaging using contrast-enhanced steady state free precession (CE-SSFP) in patients after ST-elevation myocardial infarction (STEMI). However, CE-SSFP utilizes gadolinium contrast, which is contraindicated in patients with severe renal insufficiency. Native T1-mapping is a non-contrast CMR method which
Background: Cognitive impairment is common following out-of-hospital cardiac arrest (OHCA), but the nature of the impairment is poorly understood. Our objective was to describe cognitive impairment in OHCA survivors, with the hypothesis that OHCA survivors would perform significantly worse on neuropsychological tests of cognition than controls with acute myocardial infarction (MI). Another aim was
Background: The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation to increase oxygen efficiency of adenosine triphosphate production, with mixed results. Methods: To investigate metabolic flexibility and oxygen delivery in the failing
Background and Objectives: There is considerable heterogeneity in the association between increasing β-amyloid (Aβ) pathology and early cognitive dysfunction in preclinical Alzheimer disease (AD). At this stage, some individuals show no signs of cognitive dysfunction, while others show clear signs of decline. The factors explaining this heterogeneity are particularly important for understanding pr
BACKGROUND: Osteoarthritis is a leading cause of disability worldwide. Current treatment supports coping strategies to improve health-related quality of life (HRQoL). The need to predict response to treatment has been raised to personalise care. This study aims to examine change in HRQoL from baseline to three and nine months follow-up after participating in a Supported Osteoarthritis Self-Managem
Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study ass
This article draws on usability evaluations of a behavioural change intervention delivered as a web-based course. Special attention was given to usability as the course is directed at older adults aged 70 and above. Experiences from the usability evaluations in a lab environment and the real world, followed by stepwise refinements, can serve as examples of what must be considered in developing cou
This is a study of a Soviet espionage mission in Sweden in 1942 under the aegis of the intelligence officer Vasilii Sidorenko. Aside from trying to reconstruct, on the basis of material filed with the archive of the Swedish Security Police (Säpo), the history of the mission, the article also addresses methodological challenges following from the fact that we must, as Soviet material remains very sThis is a study of a Soviet espionage mission in Sweden in 1942 under the aegis of the intelligence officer Vasilii Sidorenko. Aside from trying to reconstruct, on the basis of material filed with the archive of the Swedish Security Police (Säpo), the history of the mission, the article also addresses methodological challenges following from the fact that we must, as Soviet material remains very s
BACKGROUND: Despite the detrimental impact of abnormal glucose metabolism on cardiovascular prognosis after myocardial infarction (MI), diabetes is both underdiagnosed and undertreated. We investigated associations between structured diabetes care routines in cardiac rehabilitation (CR) and detection and treatment of diabetes at one-year post-MI.METHODS: Center-level data was derived from the Perf
Importance: This follow-up study of extremely preterm (EPT) children (<27 weeks' gestational age [GA] at birth) revealed major eye and visual problems in 37.9% (147 of 388) of all EPT infants and in 55.4% (67 of 121) of the most immature subgroups at 6.5 years of age. These major eye and visual problems were strongly associated with treatment-requiring retinopathy of prematurity (ROP).Objectives:
Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand
Background: In sub-Saharan Africa, truckers and female sex workers (FSWs) have high HIV risk and face challenges accessing HIV testing. Adding HIV self-testing (HIVST) to standard of care (SOC) programs increases testing rates. However, the underlying mechanisms are not fully understood. HIVST may decrease barriers (inconvenient clinic hours, confidentiality concerns) and thus we would expect a gr
Background and aim: To date, few studies have focused on the health effects of pesticide exposure among avocado farmworkers. We examined the association of exposure to insecticides, fungicides, and herbicides with cognitive and mental health outcomes among these avocado workers from Michoacan, Mexico. Materials and methods: We conducted a cross-sectional study of 105 avocado farmworkers between Ma
IMPORTANCE Moderate-grade adolescent idiopathic scoliosis (AIS) may be treated with full-time bracing. For patients who reject full-time bracing, the effects of alternative, conservative interventions are unknown. OBJECTIVE To determine whether self-mediated physical activity combined with either nighttime bracing (NB) or scoliosis-specific exercise (SSE) is superior to a control of physical activ
The purpose of the research was to enrich the understanding of the process of corporatization of higher education and to demonstrate the importance of studying identity work. We conducted an inductive case study research basing our methods and methodology on hermeneutics and an interpretive paradigm. We developed our argumentation on the basis of interpretive and critical theory regarding identity
During the 1950’s and 1960’s an unexplainable phenomenon arose amongst middle class women in North America. Women in the suburbs experienced a feeling of emptiness even though they believed they had everything they could ever ask for in life. This phenomenon is covered by Betty Friedan in The Feminine Mystique (1963) where she discusses the identity crisis and loss of self that many women experien
Migration has been a contested issue in Swedish politics over the past decade, and media coverage has repeatedly sparked debate about the impartiality of Sveriges Television (SVT). Using large language models (LLMs) as coding instruments, this study examines how migration has been framed in SVT Nyheter, a major Swedish public service news outlet, between 2014 and 2024. Rather than explaining causa
Antalet företagsförvärv har vuxit snabbt i Sverige under de två senaste årtiondena och är idag en del av viktiga strategiska och ekonomiska beslut för många företag. Ett företagsförvärv kan dessutom vara en mycket stor ekonomisk risk för den förvärvande parten. Denna uppsats undersöker processen för ett företagsförvärv från den förvärvande partens perspektiv samt ur ett rättsekonomiskt perspektiv.The amount of acquisitions has grown rapidly in Sweden during the past two decades and are today a very important strategic and financial decision for many companies. A corporate acquisition could also be a very big financial risk for the acquiring party. This thesis researches the process of corporate acquisitions from the perspective of the acquiring party with a focus on an economic analysis of
