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Title: Information Management in Kockums AB’s Supply Chain regarding Development Products – Driving Forces and Barriers to reach excellence
Authors: Fredrik Arborelius and Henrik Stenvinkel
Supervisors: Anders Jansson, Manager Design Support and Tactical Planning, Kockums AB
Dag Näslund, Associate Professor, Department of Industrial Management and Logistics, Lund Institute of Technolog

Popular Abstract in Swedish Transplantation av dopaminceller från mänskliga foster kan förbättra funktionen hos patienter med Parkinsons sjukdom (Lindvall 1997, Björklund 2000a). Man har kunnat visa att transplantaten har återställt dopaminproduktionen i striatum till normala nivåer i flera fall, och till 70-80% av normalt i majoriteten av de patienter som transplanterats i Lund. Transplantaten haTransplantation of embryonic human neural tissue can restore function in patients with Parkinson’s disease, but there is a severe shortage of donor tissue which limits the applicability of the technique. Embryonic neural tissue from other species, xenogeneic tissue, would provide a readily accessible donor tissue with the potential to help patients if the immunological reactions in the host could

AbstractPhysical exhaustion can constrain human ascending work capacity and performance during emergency evacuation on stairs. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations during two different strategies: self-preferred pace in three different public stairways in the field, and controlled pace in a laboratory on a stair machin

Importance: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health.Objective: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion.Evidence Review: Cause-specific mortality an

BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this syst

Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. GAGs are normally attached to a core protein as a part of a proteoglycan; however, GAG biosynthesis can be induced by compounds composed of a xylos

Importance: The association between long sleep duration and mortality appears stronger in East Asian populations than in North American or European populations. Objectives: To assess the sex-specific association between sleep duration and all-cause and major-cause mortality in a pooled longitudinal cohort and to stratify the association by age and body mass index. Design, Setting, and Participants

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

Background: Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In the case of interleukin-1 (IL-1) inhibition using its receptor antagonist (IL-1Ra), like chondrocytes, synoviocytes also express IL-1 receptors that influence intra-articular IL-1

Background: Endometriosis and irritable bowel syndrome (IBS) have similar symptoms, pathogenesis, and risk factors. These diagnoses often coexist and are frequently misdiagnosed leading to diagnostic delays. This study of a population-based cohort aimed to investigate associations relating to endometriosis and IBS and to compare gastrointestinal symptoms between endometriosis and IBS. Method: The

Importance: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date.Objective: To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality.Design, Setting, and Participants: This populatio

Colorectal cancer (CRC) is the third most common cancer worldwide. Increasing evidence suggests that CRC should be considered a heterogeneous disease, with multiple differences between proximal and distal tumours. The immune system may, depending on the context, promote or inhibit tumour growth, and different immune cell subsets have been found to be associated with impaired or improved prognosis

Importance: Better understanding is needed of the degree to which individuals tolerate Alzheimer disease (AD)-like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). Objective: To examine the demographic (age, sex, and educational level), genetic (APOE-ϵ4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors

The ice cover presence on the surface of a lake insulates the water body from the atmosphere. This prevents or reduces the influence of processes which depend on the exchange between the atmosphere and the water surface. This implies significant reduction or elimination of some processes taking place at the open water surface; for instance, a substantial reduction in solar energy penetrating to th

Surrogate measures of safety (SMoS) are meant to function as tools to investigate traffic safety. The term surrogate indicates that these measures do not rely on crash data; instead, they focus on identifying safety critical events (or near-crashes) in traffic, which can be used as an alternative to crash records. The overall aim of this thesis is to explore which SMoS are suitable when analysing

Background/Purpose: The aim of this study was to estimate the incidence rate and prevalence of coronary artery diseases (CAD) in patients with temporal artery positive giant cell arteritis (TAB+GCA) from a defined population in southern Sweden, and to describe characteristics of CAD in this sample.Methods: The study cohort consisted of 1202 patients (71.9% women) diagnosed with TAB+GCA between 199

Background: Potent antithrombotic therapy has significantly improved prognosis for patients with acute myocardial infarction (AMI), however, at a price of increased bleeding risk. Chronic gastric infection with Helicobacter pylori (Hp) commonly causes upper gastrointestinal bleeding and is proposed as a risk factor for subsequent bleeding post AMI. The prevalence of active Hp in a current AMI popu

Background If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid endarterectomy (CEA) reduces stroke incidence for some years. We assessed the long-term effects of successful CEA. Methods Between 1993 and 2003, 3120 asymptomatic patients from 126 centres in 30 countries were allocated equally, by blinded minimised rand

Objective: To study the impact of GH dose and age at GH start in girls with Turner syndrome (TS), aiming for normal height and age at pubertal onset (PO) and at adult height (AH). However, age at diagnosis will limit treatment possibilities. Methods: National multicenter investigator-initiated studies (TNR 87-052-01 and TNR 88-072) in girls with TS, age 3–16 years at GH start during year 1987–1998

Objective: Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) has previously shown alterations in cerebral perfusion in patients with systemic lupus erythematosus (SLE). However, the results have been inconsistent, in particular regarding neuropsychiatric (NP) SLE. Thus, we investigated perfusion-based measures in different brain regions in SLE patients with and without NP invo