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Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations

FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational entropy upon ligand binding. Here we report backbone and methyl-axis order parameters of the apo and FK506-bound forms of FKBP12, based on 15N and 2H NMR relaxa

Hip pain in children with cerebral palsy : A population-based registry study of risk factors 11 Medical and Health Sciences 1103 Clinical Sciences

Background: Hip pain is prevalent in children with cerebral palsy (CP). Hip displacement is a known risk factor for hip pain. However, many children do not have displaced hips but still have hip pain and the aetiologies are poorly understood. The aims of this study were to investigate: 1. the prevalence of hip pain related to age, gender, gross motor function, degree of hip displacement and 2. the

Cleavage of the alpha 1-microglobulin-bikunin precursor is localized to the Golgi apparatus of rat liver cells

alpha 1-Microglobulin, a plasma protein with immunoregulatory properties, and bikunin, the light chain of the proteinase inhibitors inter-alpha-inhibitor and pre-alpha-inhibitor, are translated as a precursor protein from the same mRNA. The cosynthesis of alpha 1-microglobulin and bikunin is unique compared to other proproteins such as procomplement components and prohormones, since alpha 1-microg

Late Local Recurrence and Metastasis in Soft Tissue Sarcoma of the Extremities and Trunk Wall : Better Outcome After Treatment of Late Events Compared with Early

Background: Approximately 80% of soft tissue sarcoma (STS) recurrences, local and metastatic disease, are diagnosed within the first 3 years after primary diagnosis and treatment. Recurrences, however, can present after a longer period of remission. Our goal was to identify factors that may predict the risk of late recurrence. Methods: We identified 677 patients with STS of the extremities and tru

Implantable cardiac devices in adult patients with repaired tetralogy of Fallot

Objectives: Implantable cardiac devices are common in patients with tetralogy of Fallot (ToF) (18.3–21.3%) according to previous reports from large centres. We conducted this study to investigate the prevalence and incidence of cardiac devices in a less selected population of patients with ToF and assess factors other than arrhythmia associated with having a device. Design: 530 adult (≥18 years) p

Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients

We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female

A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin

OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).METHODS: Histology of PM (n = 269) was evaluated

Dissertation in linguistics

Dissertation in linguistics Dissertation in linguistics Published 8 January 2020 In her dissertation Joanne Yager investigates the outcomes of language contact and multilingualism among egalitarian foragers in a small-scale multilingual setting in northern Peninsular Malaysia. Despite the fact that situations of contact between languages that are small in scale and relatively equal in prestige are

https://www.sol.lu.se/en/article/dissertation-in-linguistics/ - 2026-05-25

2024

1,2,3 Playtime. A lecture and workshop series in the field of games. 23 November 2023 to 3 October 2024 Pilot – Av jord är du kommen: Marika Hedemyr 12 December 2023 to 29 February 2024 IASPIS residency: Shitou & Ming 8 January to 31 March 2024 50% PhD seminar and documentation by Tanja Hylling Diers 18 & 19 January 2024 «Soleil-Journal» by Mariella Otto 24 to 28 January 2024 "Responding Arches" b

https://www.iac.lu.se/previous-projects/2024 - 2026-05-27

Key dates and deadlines for incoming exchange students

Lund University School of Economics and Management Spring semester 2026Semester dates: 19 January–7 June 2026Study period 3: 19 January–20 MarchStudy period 4: 23 March–7 JuneNomination period by your home university: 15–30 SeptemberOnline course application: 1–15 OctoberHousing application: NovemberCourse confirmation: End of NovemberArrival Day: 12 JanuaryOrientation Weeks: 12–18 JanuaryLUSEM Pr

https://www.lusem.lu.se/study/international-opportunities/incoming-exchange-students-lusem/key-dates-and-deadlines-incoming-exchange-students - 2026-05-28

Cutting Edge Rheumatology 2026

7 maj 2026 09:00 till 16:30 | Konferens The Kåre Berglund Foundation in collaboration with Lund University organizes a whole day Cutting Edge Rheumatology meeting featuring local and international speakers. Responsible for the current meeting are Carl Turesson, Anders Bengtsson, Meliha Kapetanovic, Nina Forss, and Mattias Collin, all at Lund University and/or Skåne University Hospital and active r

https://www.medicin.lu.se/evenemang/cutting-edge-rheumatology-2026 - 2026-05-28

Per Aspera Ad Astra: Towards the International Fiscal Meaning of the Concept 'Beneficial Owner'

The term ‘beneficial owner’ was first internationally introduced by the OECD in the Model Convention in 1977 and since that time it serves as one of the anti-abuse rules directly provided for in double tax treaties. The concept is critical for determining the eligibility of a person for the tax treaty benefits and for the allocation of taxing rights between two contracting states with regard to di

Lumes programme agenda 2015-2017 150902

Tentative Programme Agenda, LUMES 2003 - 2004 Postadress Box 170, 221 00 Lund Besöksadress Biskopsgatan 5 Telefon dir 046-222 04 70, växel 046-222 00 00 E-post info@lucsus.lu.se Internet http://www.lucsus.lu.se / http://www.lumes.lu.se LUMES Lund University International Master’s Programme in Environmental Studies and Sustainability Science LUMES Tentative Programme Agenda 2015 – 2017 (version 201

https://www.lumes.lu.se/sites/lumes.lu.se/files/lumes_programme_agenda_2015-2017_150902.pdf - 2026-05-28

Lumes programme agenda 2015-2017 160218 0

Microsoft Word - LUMES Programme Agenda 2015-2017 150902 Postadress Box 170, 221 00 Lund Besöksadress Biskopsgatan 5 Telefon dir 046-222 04 70, växel 046-222 00 00 E-post info@lucsus.lu.se Internet http://www.lucsus.lu.se / http://www.lumes.lu.se   LUMES  Lund University International Master’s Programme in Environmental Studies   and Sustainability Science    LUMES Tentative Programme Agenda 2015 

https://www.lumes.lu.se/sites/lumes.lu.se/files/lumes_programme_agenda_2015-2017_160218_0.pdf - 2026-05-28