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Background: Although it has been suggested that the hippocampus and amygdala (HA) are involved in the neurobiology of obsessive– compulsive disorder (OCD), volumetric findings have been inconsistent, and little work has been undertaken on the volumetry of the heterogeneous anatomic units of HA, with their specific functions and cytoarchitecture, in OCD. We sought to explore potential sources of he
ObjectiveTo examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE). MethodsA disease inception cohort was assessed annually for headache (5 types) and 18 other neuropsychiatric (NP) events. Global disease activity scores (SLE Disease Activity Index 2000
Although much attention in recent years has been devoted to methane (CH4) emissions from northern wetlands, measurement based data sets providing full annual budgets are still limited in number. This study was designed to help fill the gap of year-round measurements of CH4 emissions from subarctic mires. We report continuous eddy correlation CH4 flux measurements made during 2006 and 2007 over the
Background: Ultrasound-guided transvaginal oocyte retrieval is often performed under local anaesthesia on an outpatient basis. The objective of this study was to compare the overall pain experience of a newly designed reduced needle (RN) compared with a thicker standard needle (SN). Methods: A prospective, randomized, multi-centre study was performed at four different clinics from June to December
Background: The pathogenesis of COPD is complex and remains poorly understood. The European Respiratory Society Study on Chronic Obstructive Pulmonary Disease (EUROSCOP) investigated long-term effects of budesonide; 18% of the COPD participants were atopic. So far effects of atopy on the long-term course of COPD have not been elucidated. Methods: Factors related to the presence of atopy (positive
Introduction: Many individuals with Alzheimer’s disease (AD) live alone, and this figure is expected to increase. This study aimed to describe the cognitive and functional abilities of solitary-living AD patients, and the potential predictors of their usage of community-based services. Methods: This 3-year, prospective, multicenter study included 1,021 participants with mild-to-moderate AD (Mini-M
Popular Abstract in Swedish Allmän Introduktion Hormonkänsligt lipas (HKL/HSL) är det protein (enzym) som hydrolyserar (bryter ner) det fett som finns lagrat inne i fettcellerna i fettväven. HSL finns också i steroidproducerande vävnader, som t.ex. binjure, äggstockar, moderkaka och testikel, och har troligtvis en viktig funktion i steroidsyntesen i åtminstone vissa av dessa vävnader. Det är dock Hormone-sensitive lipase (HSL) is a key enzyme in adipose tissue that hydrolyses stored fat (triacylglycerol). The activity of HSL is under strict hormonal and neural control. Lipolytic agents, such as catecholamines, increase the cAMP levels, resulting in an activation of cAMP-dependent protein kinase (PKA), which in turn phosphorylates and activates HSL. This thesis describes the structural orga
Popular Abstract in Swedish Ärftlig brist på vissa proteiner ökar risken för autoimmun sjukdom eller svår hjärnhinneinflammation I blodbanan finns ett 30-tal olika proteiner som ingår i den del av vårt immunförsvar som kallas komplementsystemet. Detta systems huvudsakliga uppgifter är att förinta oönskade inkräktare, såsom bakterier och virus, samt eliminera skadliga proteinkomplex som cirkulerarComplement deficiency is associated with an increased risk for invasive infection and immune complex disease. Screening for identification of complement-deficient patients is essential and a new ELISA-based procedure for detection of complement deficiency is described. Molecular characterization of a complete C4 deficiency and of three phenotypic forms of properdin deficiency is also reported. The
Objective. Helicobacter pylori infection is an established risk factor for non-cardia gastric adenocarcinoma. Infection with H. pylori strains harbouring the cagA pathology island may augment this association. H. pylori infection may at the same time reduce the risk for oesophageal carcinoma. However, prospective data on the association between CagA seropositivity and gastric or oesophageal carcin
BACKGROUND: Reduced lung function has been associated with increased rates of myocardial infarction. Whether the occurrence and prognostic significance of ventricular arrhythmia is related to lung function is largely unknown. METHODS AND RESULTS: We performed a population-based study of 68-year-old men without a history of stroke or myocardial infarction; 402 men participated. Mortality and corona
Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was m
Popular Abstract in Swedish Missbrukande kvinnor och mammor har ofta fördömts av samhället och av människor i sin omgivning. De har setts som ansvarslösa kvinnor och olämpliga mammor utifrån en samhällssyn, att barn och missbruk inte går ihop. De livshistoriska intervjuerna med missbrukande kvinnor och mammor, som avhandlingen bygger på visar, att kvinnorna både vill vara respektabla och ta väl haThe aim of the dissertation is to describe the conditions under which substance abusing women live with regard to their families, the substance abuse and treatment. The interaction between the substance abusing women and the institutional expectations is analysed from gender and class perspective. The dissertation is based on interviews with two groups of substance abusing women: 12 mothers, livin
This study is concerned about the effects of brine discharge into the Arabian Gulf and desalination plants location also. The major concern is the Arabian coastline of the Gulf countries which started from Kuwait whole way to United Arab Emirates. Different scenarios for desalination plant and brine discharge management in the Arabian Gulf are discussed using mass balance computations. The Arabian
Purpose: To examine whether panretinal photocoagulation for severe non-proliferative retinopathy in type 1 diabetes patients could halt the progression of retinopathy with subsequent vitreous haemorrhages and visual impairment. Methods: During a 10-year follow-up study period of 344 type 1 diabetes patients, 81 subjects went through panretinal photocoagulation. Forty patients were treated for sev
OBJECTIVES: To clarify whether the intensity of exposure to organic acid anhydrides (OAAs) is associated with the risk of sensitisation to these allergens. METHODS: The investigations were carried out in three different manufacturing plants (A, B, and C) where OAAs were used in the production of epoxy resins. Methyltetrahydrophthalic acid anhydride (MTHPA) was used in all three plants. The exposur
We present the red-listed plants and fungi that have been found in the central parts of the parish of Stenbrohult, southern Sweden. In the middle of the study areas Carl Linnaeus was born in 1707, and he spent his summers there until 1727. Of the 11 currently red-listed vascular plants (Gärdenfors 2000) that have been recorded since 1970 all occurred there also 300 years ago. Mosses, lichens and f
Background Calcipotriol and betamethasone dipropionate are both widely used, effective treatments for psoriasis. Vitamin D analogues and topical corticosteroids have different mechanisms of action in the treatment of psoriasis. A new vehicle has been developed in order to contain both calcipotriol (50 micro g g-1) and betamethasone dipropionate (0.5 mg g-1) in an ointment form. By using calcipotri
Objective: Non-obese patients with type 2 diabetes (T2DM) are characterized by predominant defective insulin secretion. However, in non-obese T2DM patients, metformin, targeting insulin resistance. is non-inferior to the prandial insulin secretagogue, repaglinide, controlling overall glycaemia (HbA(1c)). Whether the same apply for postprandial glucose and lipid metabolism is unknown. Here. we comp
Increased mortality risks associated with smoking are well established among men. There are very few population-based studies comprising a sufficient number of heavily smoking women, measuring the direct effect of smoking on mortality risks. Between 1974 and 1992, 8,499 women and 13,888 men attended a health screening programme including reporting of smoking habits. Individuals were followed for t
