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RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the "stringent" response and regulator of cellular metabolism. The classical "long" RSHs Rel, RelA and SpoT with the ppGpp hydrolase, synthetase, TGS and ACT domain architecture

Background: To use the European Association of Urology Research Foundation (EAURF) registry data to determine the proportion of contemporary Lower Urinary Tract Symptoms associated with Benign Prostatic Enlargement (LUTS/BPE) patients prescribed phytotherapy, and to determine their subjective quality of life and clinical progression responses. Methods: This was a prospective multicenter multinatio

PURPOSE: To calculate the normal tissue complication probability (NTCP) of late radiation effects on the rectum and bladder from repetitive CT scans during fractionated high-dose-rate brachytherapy (HDRB) and external beam radiotherapy (EBRT) of the uterine cervix and compare the NTCP with the clinical frequency of late effects.METHODS AND MATERIALS: Fourteen patients with cancer of the uterine ce

Microfluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. This could play a major role in diagnosis of a wide range of diseases which are prevalent in remote areas in developing countries where a majority of the peopMicrofluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. This could play a major role in diagnosis of a wide range of diseases which are prevalent in remote areas in developing countries where a majority of the peop

Shrunken pore syndrome (SPS) is defined by a cystatin C-based estimation of glomerular filtration rate (eGFRCYS) being less than 60% or 70% of a creatinine-based GFR estimation (eGFRCR) in the absence of extrarenal influences on cystatin C or creatinine concentrations. SPS has been associated with a substantial increase in mortality or morbidity in all investigated populations. However, in these s

Introduction Patient outcome measures are required to assess the quality of healthcare. Tools for a patients' self-assessment of quality of recovery, during perioperative care, have been developed during the last decade. The Postoperative Quality of Recovery Scale (PostopQRS) questionnaire is one of the most well-accepted and validated tools available. Here we assess the PostopORS questionnaire in

10Be in ice cores has been instrumental for reconstructing past changes in solar activity prior to direct observations. For a robust use of these records, it is pivotal to understand the 10Be transport and deposition. However, there are only few high-resolution seasonal 10Be data longer than one full solar cycle (11 years) that could enable a quantification of the influences of atmospheric circula

Context.-The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non-small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. Objective.-To determine the diagnostic value of insulinoma-associated protein 1 (INSM1), in comparison with established NE markers, in pulmonary tumors. D

Popular Abstract in English What is common between the science of physics and global politics? They both define power in terms of energy. Indeed, the uneven distribution of petroleum reserves has been one of the main reasons of social, political and economic problems worldwide. Even more worrying is the rapid increase in the levels of greenhouse gases in the atmosphere. This is mainly caused by ouCaldicellulosiruptor saccharolyticus is an extremely thermophilic, strictly anaerobic, Gram-positive and cellulolytic microorganism with a natural ability to produce hydrogen (H2) at nearly theoretical maximum yield, i.e. 4 mol/ mol of glucose. Due to its CO2-free combustion and high energy density, among other desirable properties, H2is touted as a fuel of the future. Biological H2 production b

Importance: The effect of a physical property of irrigation fluid (at body vs room temperature) on recurrence rate in the evacuation of chronic subdural hematoma (cSDH) needs further study. Objective: To explore whether irrigation fluid temperature has an influence on cSDH recurrence. Design, Setting, and Participants: This was a multicenter randomized clinical trial performed between March 16, 20

Denna rapport utgör en syntes av de sju projekt som finansierades inomNaturvårdsverkets och Havs- och vattenmyndighetens forskningssatsning inomområdet ekologisk kompensation som pågick 2018–2021. Syntesprojektet har utgått dels från slutrapporterna från de enskilda projekten, dels från myndigheternas uttryckta önskemål om belysning av vissa specifika aspekter inom tillämpningen av ekologisk kompeThis report represents a synthesis of seven ”environmental compensation1” research projects funded by the Swedish Environmental Protection Agency and Swedish Agency for Marine and Water Management between 2018 and 2021. This synthesis has been built upon the final reports of each individual research project, as well as comments provided by the two funding agencies that emphasized specific aspects

Questions: Earth observation is an important tool in biological monitoring. Previous studies have shown that variation in grassland canopy reflectance can explain gradients in plant community composition. However, there is a need for methods that allow the interpretation of the overall spectral signal of complex grassland vegetation in terms of existing knowledge about individual species' habitat

BACKGROUND: Although large studies and pooled analyses of individual patient data have demonstrated the safety of deferring coronary revascularization based on a nonischemic intracoronary pressure index result, conflicting findings have emerged in specific patient subsets and with varying follow-up. Thus, we conducted an updated comprehensive systematic review and meta-analysis to investigate the

Dopamine D2 receptors (D2-R) in extrastriatal brain regions are of high interest for research in a wide range of psychiatric and neurologic disorders. Pharmacological competition studies and test-retest experiments have shown high validity and reliability of the positron emission tomography (PET) radioligand [11C]FLB 457 for D2-R quantification in extrastriatal brain regions. However, this radioli

Att sluta begå brott handlar inte enbart om förändrade handlingar, utan också om hur individer omformulerar vem de är. Denna avhandling analyserar hur unga personer med erfarenhet av kriminalitet konstruerar och förhandlar sina identiteter i berättelser om brottsdebut, fortsatt brottslighet och upphörande med brott. Avhandlingen behandlar tre centrala frågor: (1) Vilka innehållsmässiga komponenterIn this thesis I explore how young people with a criminal record choose to construct and negotiate their identities in narratives about debut offences, re-offending, and desistance. I address three key questions: (1) What content-related components are central to young people’s narratives of desistance? (2) What linguistic and cultural resources do young people draw on to present themselves as cre

Objectives: To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA). Methods: Data on biologics-naïve adults with axSpA were captured from European rheumatology registries. Information on lifestyle factors (smoking, overweight/obesity, and/or alcohol consumption) were identified ± 30 days of commencing their f

The global aviation industry is experiencing growing pressure to decarbonize, driving significant demand for Sustainable Aviation Fuel (SAF). Second-generation feedstocks that do not directly compete with food crops, such as lipid oils from insects and lignin-derived oils, are promising sources, but their high concentrations of inorganic contaminants and oxygen make them incompatible with existing

Background: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were i

Background and Problem: Existing healthcare systems have been put under immense pressure during the COVID-19 pandemic. Disruptions in essential maternal and newborn services have come from even high-income countries within the World Health Organization (WHO) European Region. Aim: To describe the quality of care during pregnancy and childbirth, as reported by the women themselves, during the COVID-