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A growing body of evidence points out the potential role of inflammatory mechanisms in the pathophysiology of brain damage in dementia. We have recently demonstrated that patients with Alzheimer's disease (AD) and vascular dementia (VaD) display an intrathecal production of proinflammatory cytokines. TNF-alpha, one of these cytokines, leads to the production of nitric oxide (NO), a potent inflamma
Droughts affect ecosystems at multiple time scales, but their sub-seasonal legacy effects on vegetation activity remain unclear. Combining the satellite-based enhanced vegetation index MODIS EVI with a novel location-specific definition of the growing season, we quantify drought impacts on sub-seasonal vegetation activity and the subsequent recovery in the Northern Hemisphere. Drought legacy effec
Background: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. Methods: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a trip
This paper presents a technique to reduce the noise figure of a passive mixer-first receiver front-end. By using lower than 50Ω switch resistance in the current-mode passive mixer and introducing a positive feedback from baseband to the RF-input, it can be well matched close to fLO while achieving a noise figure below 3dB, which is otherwise a fundamental limit. A quadrature front-end prototype fo
This thesis studies the efforts made by society to achieve more efficient energy use in order to better utilise resources and lessen the stress on the environment. Despite the value to society promised by more efficient energy use, too few attempts are made at realising this value. One instrument available to governments in their efforts to stimulate efficiency schemes, is to encourage energy comp
From newly obtained high-resolution, high signal-to-noise ratio spectra the abundances of the elements La and Eu have been determined over the stellar metallicity range -3<[Fe/H]<+0.3 in 159 giant and dwarf stars. Lanthanum is predominantly made by the s-process in the solar system, while Eu owes most of its solar system abundance to the r-process. The changing ratio of these elements in stars ove
A second generation of a substrate-selective dynamic supramolecular catalytic system consisting of a catalyst part and a receptor part, connected by a hydrogen-bonding motif, has been realized based on rational design. The results from analyses of the equilibrium mixture of the species generated by the components of the first generation system led us to selectively lock the cisoid conformation of
This article explores whether the impact of marital status on the risk of preterm birth varies in relation to marital practices in the population, defined by the proportion of out-of-marriage births. Data come from a case–control study of the determinants of preterm birth in 16 European countries (5456 cases and 8234 controls). There is a significantly elevated risk of preterm birth associated wit
Disease gene identification is still a challenge despite modern high-throughput methods. Many diseases are very rare or lethal and thus cannot be investigated with traditional methods. Several in silico methods have been developed but they have some limitations. We introduce a new method that combines information about protein-interaction network properties and Gene Ontology terms. Genes with high
Popular Abstract in English As far as we know the Northern Fulmar (just referred to as Fulmar from her on), did not start breeding on the Faroe Islands before about 150 years ago. But it has been known by the Faroese for a long time. Mainly as a bad omen and according to folklore fishermen would return home if they encountered Fulmars when out at sea, since they believed it was the bringer of storThe Northern Fulmar (Fulmarus glacialis) is one of the most abundant seabirds in the Northern Hemisphere and the most abundant seabird on the Faroe Islands. Except from a few sporadic observations up until the 1950´s no study has focused on this species on the Faroe Islands. Being considered a significant consumer of marine resources in the Faroese marine ecosystem a closer study of this species´
Electricity must be produced at the same time as it is used. This necessitates flexibility in the electricity production and electricity networks. Until recently, the increase in electricity demand and peak power demand has been met by expansion of the electricity production. Today, due to the deregulation of the electricity market, the production capacity is decreasing. Therefore, there is a nati
A systematic study was conducted over six years (1994-1999) on a shallow ice covered lake in the Russian Republic of Karelia with the aim of developing better understanding of some physical processes occurring in shallow ice-covered lakes. The average ice-covered period was 182 days while the longest ice-covered period was 193 days. The average lake water temperature at ice formation was 0.5-10deg
There is accumulating evidence that gestational diabetes (GDM) is a growing problem. The lack of internationally standardized diagnostic procedures prevents consistent diagnosis and the burden of GDM must be determined in country-specific studies. In southern Sweden, GDM is defined as a 2-hour capillary plasma glucose concentration of ≥10.0 mmol/L during a universal 75 g oral glucose tolerance tes
The Na-33 beta decay was studied online using mass separation techniques and a first description of the level structure of the neutron-rich isotope Mg-33, with N=21, has been obtained. The experiment involved the measurement of beta-gamma, beta-gamma-gamma, and beta -n-gamma coincidences as well as neutron spectra by time-of-flight technique. The first low energy level scheme for the daughter nucl
Eight children (1--17 yr) underwent bone marrow harvesting while in cytostatic-induced remission of their disease (leukemia [n = 6], Ewing sarcoma, and non-Hodgkin lymphoma). After the induction of general anesthesia, all patients were loaded with 10 mL/kg of a 6% high-molecular dextran solution (Macrodex — Pharmacia), which resulted in a significant preoperative decrease in hematocrit (Hct) from
