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52521 Neurologi 2_19 42 neurologi i sverige nr 2 – 19 Huntingtons Huntingtons sjukdom är en neu- rodegenerativ sjukdom i gränslandet mellan neurologi, psykiatri och klinisk genetik. Den leder till för tidig död och det finns ingen sjukdomsuppbromsan- de behandling. Huntingtons sjukdom är orsakad av en CAG-expansion i hun- tingtongenen som nedärvs autosomalt dominant med full penetrans, det vill sä
The Internet of Things (IoT) paradigm, has opened up the possibility of using the ubiquity of small devices to route information without the necessity of being connected to a Wide Area Network (WAN). Use cases of IoT devices sending updates that are routed and delivered by other IoT devices have been proposed in the literature. In this paper we focus on receivers only interested in the freshest up
En vägöverbygganad består av olika materiallager med specifika funktioner som tillsammans underlättar uppfyllande av krav på säkerhet, beständighet och livslängd. Dimensioneringen av överbyggnader är en process som syftar till att bestämma lämpliga och tillräckliga tjocklekar på ingående materiallager. Denna process äger rum med hjälp av dimensioneringsprogram bland annat ERAPAVE PP (Elastic RespoA road superstructure consists of different material layers with specific functions that together facilitate the fulfilment of requirements for safety, durability and service life. The design of superstructures is a process that aims to determine suitable and sufficient thicknesses of included material layers. This process takes place with help of dimensioning programs including ERAPAVE PP (Elasti
Newly qualified social workers (NQSW) in Sweden are often thrust into statutory social work. In the context of statutory social work, social workers need to navigate a professional rationale, on which the social work profession rests, with an organizational rationale, on which the welfare organization – the social services – rests. This is due to the fact that social workers often are reliant on w
The impact of COVID-19 had unprecedented effects on the international labour market. Businesses went bankrupt, employees were fired, and organisations and employees had to adapt to swiftly working remotely from the office. Extensive studies have been conducted concerning the transition from in-person to remote work, but less so on how the transition from remote work to in-person work in a post-COV
Internal combustion engines have been the most used engine design when it comes to vehicle propulsion and transportation. But as the number of vehicles increase, new problems arise as well. Engine emissions such as carbon dioxide that has an effect on a global scale and other harmful emissions that affect on a local scale such as soot and nitrogen oxides are on the rise, forcing the countries to t
Individer lämnar och har alltid lämnat arbetslivet på grund av att åldern ”tar ut sin rätt”. Dock är det sannolikt inte ålderssvaghet som är den avgörande faktornför det stora flertalet som går i ålderspension idag. Troligtvis är det istället mångaolika faktorer som har betydelse för när en individ lämnar yrkeslivet för en nylivsfas som ålderspensionär, även om det biologiska åldrandets klocka ticIn the health and medicine care service there are employees from different kind of occupations who can and want to work until they are 65 years or older. There are also employees from different occupations who can not or do not want to work until they are 65 years old. This study includes answers from 1,949 employees in nine different occupations in health and medical care service. The aim of the
The present article was presented at the ATRIP Congress 2015. The main question addressed is whether reinterpretation, reformulation or replacement of Article 53 (c) of the European Patent Convention is viable and advisable. The issue is addressed by reference to both novel and resurfacing interpretative concerns connected with emerging technologies exemplified by nanomedicine, but also considerin
Browning of surface waters, as a result of increasing dissolved organic carbon and iron concentrations, is a widespread phenomenon with implications to the structure and function of aquatic ecosystems. In this article, we provide an overview of the consequences of browning in relation to ecosystem services, outline what the underlying drivers and mechanisms of browning are, and specifically focus
The sustainable development of cities is threatened by a worldwide water crisis, which puts urban water services (including drinking water, sanitation, and drainage) at increasing risk. Despite a shared understanding of the importance of addressing the issue, there is a peculiar lack of action and resistance at all levels. To make matters worse, risk reduction and resilience building measures seem
We have examined the effect of bradykinin (BK) and other peptide mediators with related cellular actions on tyrosine phosphorylation in confluent Swiss 3T3 fibroblast cells using an anti-phosphotyrosine antibody. Immunoblots of extracts from cells stimulated with BK showed a major heterogeneous band centered at Mr 120,000. Three phosphorylated protein species were present within this band. The low
OBJECTIVE: There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact.RESEARCH DESIGN AND METHODS: The European Prospective Investigation into Cancer (EPIC)-Inte
Background: Managing acute abdominal pain in the large and growing population of Roux-en-Y gastric bypass (RYGB)–operated patients poses a challenge to general surgeons, because of diagnostic limitations and the risk of internal herniation. Objective: To investigate the diagnoses, management, and outcome of RYGB patients admitted for acute abdominal pain. Setting: University Hospital, Sweden. Meth
Background: Production of second-generation bioethanol and other bulk chemicals by yeast fermentation requirescells that tolerate inhibitory lignocellulosic compounds at low pH. Saccharomyces cerevisiae displays high plasticitywith regard to inhibitor tolerance, and adaptation of cell populations to process conditions is essential for reachingefficient and robust fermentations.Results: In this stu
Spy scandals in Western democracies can be seen as a power battle between three actors: investigative journalists, whistleblowers and the intelligence organizations at the center of the scandal. It is a conflict played out both within and outside of the court-house as the actors try to claim the label “hero” for themselves while actively trying to repudiate other labels, such as “traitor”, “spy” o
Worship space acoustics have been established as an important part of a nation’s cultural heritage and area of acoustic research, but more research is needed regarding the region of northern Europe. This paper describes the historical acoustics of an important abbey church in Sweden in the 1470s. A digital historical reconstruction is developed. Liturgical material specific to this location is rec
