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Popular Abstract in English Universal Burdens There are Zen students who are in chains when they go to a teacher, and the teacher adds another chain. The students are delighted, unable to discern one thing from another. This is called 'a guest looking at a guest.' -Linji What do Zen master Linji, Muslim scholar ‘Abbād ibn Sulaymān, and Comanche thinker Parra-Wa-Samen have in common? Among manyZen Buddhists have long given the following advice to attain liberation: “Eat when you’re hungry. Sleep when you’re tired.” In other words: “Freedom” is the “knowledge of necessity” (Hegel, Marx, and Engels). Early Islamic communities dealt with the challenge of internal warfare and tyranny and concluded that, “sixty years of tyranny is better than one day’s anarchy.” In other words, the worst-cas

Popular Abstract in Swedish Två svenska longitudinella kohort studier är basen för denna avhandling som analyserar välbefinnandet hos yngre äldre och äldre äldre. LUND 80+startade 1988, när deltagarna i undersökningen var 80 år gamla (N=212) med årliga uppföljningar tills alla avlidit. DALBY 67+ undersökningen började 1969, när deltagarna var 67 år gamla (N=192) och har följts till 92 års ålder. BTwo Swedish longitudinal cohort studies form the basis for this thesis that examines the components of well-being from young old to oldest old. The Lund 80+ cross-sequential design began in 1988 when participants were 80-years old (N=212) and follows them annually until all are deceased. The Dalby 67 began in 1969 when participants were 67 years old (N=192) and continued until they reached 92 year

Cardiac resynchronization therapy (CRT) has a well-documented positive effect on mortality and heart failure morbidity. The aim of this study was to assess the long-term survival and the predictive value of self-assessed functional status on the long-term prognosis of patients treated with CRT-pacemaker (CRT-P).METHODS AND RESULTS: Data were retrospectively collected from medical records of 446 co

Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri

We have compiled data on the occurrence of a threatened beetle, Osmoderma eremita, in Sweden. The species inhabits tree hollows with wood mould. The data were compiled from field surveys conducted in 1993-2003, using pitfall traps at 401 localities and using wood mould sampling at 104 localities. We have also gone through published data and all larger Swedish museums and registered old records. O.

I denna avhandling används samtalsanalys (”conversation analysis”) för att studera ”riskstrategier” i samtal mellan lärare, elever och föräldrar i grundskolan. Materialet består av 80 samtal som insamlats vid två olika tidpunkter: 45 st. inspelade 1992–93 (kvartssamtal, eller den mer formella benämningen enskilda samtal) och ytterligare 35 st. inspelade 2004 (utvecklingssamtal, den benämning som gIn this thesis, conversation analysis (CA) is applied to study “risk strategies” in parent-teacher-student conferences in the Swedish nine-year compulsory school. The material consists of 80 conferences collected at two different points in time: 45 from the period 1992–93 (at that time called kvartssamtal, lit. “quarter of an hour conference”) and another 35 collected in 2004 (at the present time,

Popular Abstract in Swedish Cystisk fibros (CF) är den vanligaste svåra ärftliga metabola sjukdomen i den vita befolkningen. I Sverige drabbar den ca 1:4500-6500 individer men i många länder har den en högre incidens på ca 1:2000-3000. Trots en klart förbättrad överlevnad det senaste decenniet är det fortfarande många som dör i ung ålder. Den vanligaste dödsorsaken är lungkomplikationer till följdCystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. The chronic lung disorder is the main cause of mortality. Endogenous and exogenous factors, which may c

Background Low socioeconomic status (low education and income level) has been found to be associated with increased stroke mortality. However, findings from previous studies on the association between socioeconomic status and case fatality (survival) after stroke have been inconsistent. Aims The study aims to explore the association between socio-economic status and survival after stroke using Rik

Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

Background: Swedish Emergency Departments (EDs) see 2.6 million visits annually. Sweden has a strong tradition of health care databases, but information on patients’ pathways to the ED is not documented in any registry. The aim of this study was to provide a national overview of pathways, degree of medical acuteness according to triage, chief complaints, and hospital admission rates for adult pati

Introduction: Hip fractures are a common problem of the elderly population with significant mortality and morbidity. The choice between total hip arthroplasty (THA) and hemiarthroplasty depends on multiple factors including comorbidity. The Swedish Hip Arthroplasty Register (SHAR) provides a unique opportunity to study mortality and revision rates in this population. Linkage with government databa

Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively fo

Background: The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net. Methods: We conducted a retrospective cohort study of adult

Background: The treatment strategy for proximal aortic disease or type I endoleak after previous infrarenal repair has traditionally been open surgery. As endovascular treatment options with fenestrated and branched stent grafts increasingly rival open surgery for juxtarenal and pararenal aortic aneurysms, secondary proximal repair may similarly be performed endovascularly. Fenestrated stent graft

Late mortality of European 5-year survivors of childhood or adolescent cancer has dropped over the last 60 years, but excess mortality persists. There is little information concerning secular trends in cause-specific mortality among older European survivors. PanCareSurFup pooled data from 12 cancer registries and clinics in 11 European countries from 77 423 five-year survivors of cancer diagnosed

INTRODUCTION: The aim was to investigate psychiatric health care utilization two years before death by suicide among individuals with previous suicide attempts (PSA) compared with those without (NSA).METHOD: A retrospective population-based cohort study was conducted including 484 individuals who died by suicide in Sweden in 2015 and were in contact with psychiatric services within the two years p

Purpose Despite data showing breathlessness to be more prevalent in older adults, we have little detail about the severity or multidimensional characteristics of breathlessness and other self-reported measures (such as quality of life and other cardiorespiratory-related symptoms) in this group at the population level. We also know little about the relationship between multidimensional breathlessne

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role

Att tvångsomhänderta ett barn är ett undantag från svensk inställning att vård ska ske genom frivillighet. Det är inget som görs lättvindigt och det krävs att det finns en påtaglig risk för att barnets hälsa eller utveckling annars kommer till skada. Men hur stora krav finns det i samband med vårdens avslutande, var ligger fokus när den bedömningen görs? Syftet med detta arbetet är att titta på föTo take a child into public care against the parents will is an exception from the Swedish standpoint that all care should be given on a voluntary basis. It requires that there is a noticeable risk that the child's health or development will come to harm. But what are the demands when deciding whether the care should come to an end? Where is the focus in that process? The aim of this study is