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BACKGROUND: There are inconsistent data regarding the association between metabolic factors, separately and combined, and the risk of prostate cancer and death from prostate cancer. METHODS: In the Metabolic Syndrome and Cancer Project (Me-Can), data on body mass index (BMI); blood pressure; and blood levels of glucose, cholesterol, and triglycerides were collected for 289,866 men. Cox proportiona
Popular Abstract in Swedish Cystisk fibros (CF) är den vanligaste svåra ärftliga metabola sjukdomen i den vita befolkningen. I Sverige drabbar den ca 1:4500-6500 individer men i många länder har den en högre incidens på ca 1:2000-3000. Trots en klart förbättrad överlevnad det senaste decenniet är det fortfarande många som dör i ung ålder. Den vanligaste dödsorsaken är lungkomplikationer till följdCystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. The chronic lung disorder is the main cause of mortality. Endogenous and exogenous factors, which may c
Cardiac resynchronization therapy (CRT) has a well-documented positive effect on mortality and heart failure morbidity. The aim of this study was to assess the long-term survival and the predictive value of self-assessed functional status on the long-term prognosis of patients treated with CRT-pacemaker (CRT-P).METHODS AND RESULTS: Data were retrospectively collected from medical records of 446 co
Background. The use of left ventricular assist devices (LVADs) is established as a bridge to heart transplantation. Methods. All Swedish patients on the waiting list for heart transplantation, treated with LVAD since 1993 were retrospectively collected into a database and analyzed in regards to risk factors for mortality and morbidity. Results. Fifty-nine patients (46 men) with a median age of 49
Objective: Oesophageal atresia is an congenital anomali with incidence of 1/3000-1/4500 live births. The results of reconstructive surgery has improved greatly, to 80-92% survival reported in the last two decades. The aim of this study was to determine the incidence of oesophageal atresia in Iceland and to evaluate the results of operations at the Department of Pediatric surgery at The Children's
Background Low socioeconomic status (low education and income level) has been found to be associated with increased stroke mortality. However, findings from previous studies on the association between socioeconomic status and case fatality (survival) after stroke have been inconsistent. Aims The study aims to explore the association between socio-economic status and survival after stroke using Rik
Call for project proposal[1] 2021-03-01 CALL Call for project proposal The Centre for Advanced Middle Eastern Studies (CMES) supports research projects with high scientific potential through the Strategic Research Area (SRA) Middle East in the Contemporary World (MECW). CMES funds one new research project per year and encourages cooperation between researchers from different disciplines within Lun
https://www.cmes.lu.se/sites/cmes.lu.se/files/2021-03/Call%20for%20project%20proposal_0.pdf - 2026-07-17
Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers OR I G I N A L AR T I C L E Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers Bobbie-Jo M. Webb-Robertson1,2 | Lisa M. Bramer3 | Bryan A. Stanfill3 | Sarah M. Reehl3 | Ernesto S. Nakayasu1 | Thomas O. Met
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-06/121_MP193_Webb-Robertson_JDiabetes_2020%20(2).pdf - 2026-07-17
I familjerätten finns två former av vårdnad, ensam vårdnad och gemensam vårdnad. Den sistnämnda vårdnadsformen utgör utgångspunkten vid bedömningen av vilken vårdnadsform som är lämpligast. En utgångspunkt som har varit så stark att den har gett upphov till en presumtion för gemensam vårdnad. Uppsatsen undersöker den gemensamma vårdnadens rättsutveckling med utgångspunkt i vårdnadsreformerna 199Within the area of family law there exists two forms of legal child custody, sole custody and joint custody. The last form is the starting point in court when deciding upon which form of custody constitutes the most suitable one. The strength of the previously mentioned starting point are of such degree that a presumption for joint custody took shape. The essay examines how the development of chi
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed against the nuclear antigens will form large immune complexes (ICs) which are central in the immunop
Background - In patients with chronic heart failure (CHF), a beta-blocker is generally added to a regimen containing an angiotensin-converting-enzyme ( ACE) inhibitor. It is unknown whether beta-blockade as initial therapy may be as useful. Methods and Results - We randomized 1010 patients with mild to moderate CHF and left ventricular ejection fraction <= 35%, who were not receiving ACE inhibitor
Background: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) enables sensitive detection and staging of prostate cancer, yet its relationship with long-term survival remains unclear. This study aimed to assess whether total lesion volume (TLV) measured on [18F]PSMA-1007 PET/CT predicts overall survival (OS) in prostate cancer patients. Methods: A co
Purpose Despite data showing breathlessness to be more prevalent in older adults, we have little detail about the severity or multidimensional characteristics of breathlessness and other self-reported measures (such as quality of life and other cardiorespiratory-related symptoms) in this group at the population level. We also know little about the relationship between multidimensional breathlessne
Background: The range of onset ages within some PSEN1 families is wide, and a few cases of reduced penetrance of PSEN1 mutations have been reported. However, published data on reduced penetrance have been limited to clinical histories, often collected retrospectively and lacking biomarker information. We present a case of reduced penetrance of the PSEN1 H163Y mutation in a carrier prospectively fo
Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t
Introduction: Hip fractures are a common problem of the elderly population with significant mortality and morbidity. The choice between total hip arthroplasty (THA) and hemiarthroplasty depends on multiple factors including comorbidity. The Swedish Hip Arthroplasty Register (SHAR) provides a unique opportunity to study mortality and revision rates in this population. Linkage with government databa
Background: The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net. Methods: We conducted a retrospective cohort study of adult
Background: The treatment strategy for proximal aortic disease or type I endoleak after previous infrarenal repair has traditionally been open surgery. As endovascular treatment options with fenestrated and branched stent grafts increasingly rival open surgery for juxtarenal and pararenal aortic aneurysms, secondary proximal repair may similarly be performed endovascularly. Fenestrated stent graft
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of
