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Human antibodies directed towards functionally associated tumor antigens have great potentials as adjuvant treatment in cancer therapy. Here we describe an efficient subtractive approach to select single chain Fv (scFv) antibodies, specifically binding to unknown rapidly internalizing tumor-associated antigens (TAA) on human breast and pancreatic carcinoma cell lines. After re-engineering the scFv
Context: Despite the substantive societal impact of prostate cancer, the medical community is currently divided on the balance between benefit and harm of screening for prostate cancer using prostate-specific antigen (PSA). Objective: To examine whether PSA-based screening for prostate cancer meets current guidelines on efficacy and effectiveness for screening, and how it compares with other curre
similar to SbVO4 is a well known catalyst used for the ammoxidation of propane to acrylonitrile. However, little importance is usually given to the structural flexibility exhibited by the similar to SbVO4 phase, which has rutile-type structure and can accommodate up to 1/8 of cation vacancies. In this work we highlight the great structural flexibility exhibited by this phase accommodating the chan
Popular Abstract in Swedish De flesta större operationer på hjärtat idag kräver att hjärtat under en del av operationen står stilla utan att blod cirkulerar igenom det. För att kunna bibehålla ett blodflöde av syresatt blod genom kroppen kopplas en hjärt-lungmaskin till patienten. Blodet förs via slangar från höger förmak först ner till ett uppsamlingskärl, varifrån blodet pumpas vidare genom en oThe use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has also been studied. Whether they affect t
Popular Abstract in English Typically, when we speak of ionic solutions we mean a salt (as solute) dissolved in some liquid (the solvent). In this thesis, we predominantly consider ionic solutions for which there is no solvent---room-temperature ionic liquids (RTILs). It follows that these liquids have a large concentration of charged particles, a property that causes them to be effective electrRoom-temperature ionic liquids (RTILs) are compounds composed entirely of ions, which are liquid at temperatures below 100 degrees Celsius. Their high ionic strength and strong coupling make them useful for a number of applications, e.g. as electrolytes in supercapacitors. These properties also make them interesting subjects for theoretical research, as the canonical theories of the electrical dou
The recognition of a strong etiological relationship between infection with high-risk human papillomavirusses and cervical cancer has prompted research to develop and evaluate prophylactic and therapeutic vaccines. One prophylactic quadrivalent vaccine using L1 virus-like particles (VLP) of HPV 6, 11, 16 and 18 is available on the European market since the end of 2006 and it is expected that a sec
Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 18 yr. Auer rods were the most consistent t(8;21)-associated morphological finding
Aims: This study looked at whether oral desmopressin, by decreasing kidney urine production, would prolong bladder filling-time thereby increasing the time to reach maximum capacity, thus reducing overactive bladder (OAB) symptoms, and providing an alternative method of treatment to OAB sufferers. Methods: An investigator-initiated, 2-week, multi-national, multi-centre, "proof-of-concept," phase I
Five acute leukaemia or highly malignant lymphoma patients at a hospital in southern Sweden were interviewed about their daily living problems, their coping strategies and their opinions about the nursing care they received during the active phase of their treatment. In addition the EORTC QLQ-C30, the Global Life Quality and the Sense of Coherence scales were administered. The data were analysed f
Information on floral resource costs is fundamental for understanding how selection operates on floral morphology. In this study, I explored the cost of maturing flowers in a self-incompatible population of the ligulate composite Crepis tectorum L. by experimentally manipulating floral investment and then monitoring the response in reproductive effort. Plants on which the heads were removed during
Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. Currently, the absence of efficacious and safe methods to deliver nucleic acids to intracellular sites of action is the main impediment to th
Abstract in UndeterminedThe indigenous psychologies (mostly, Non-Western approaches to scientific research in psychology) occur in different varieties but they all aim to be culturally and pragmatically relevant to the researcher’s own society. In these psychologies Western mainstream psychology has been argued to be too affected by liberal, individualistic and secular values. Some examples of suc
This report describes the results obtained from fire tests in a 1/3-scale room. The aim of the study was to investigate how changes in external radiation and oxygen supply affect the production of smoke and toxic gases. The ventilation was varied to simulate under- and well-ventilated fires. The thermal exposure to the materials was varied to simulate fires of different sizes. Fifty-nine tests wer
Background and aims: Oral aminosalicylates are well established in the treatment of active mild/moderate ulcerative colitis (UC) when the disease is extensive (that is, beyond the splenic flexure). The majority of clinical symptoms relate to disease activity in the distal part of the colon and therefore this study was designed to investigate if adding a mesalazine enema to oral mesalazine has addi
Epitaxially-grown InAs nanowires may have great potential for nanowire device applications, due to the high electron mobility and narrow direct band gap of this material. Various applications will most likely require different selected growth conditions, due to such factors as temperature-sensitive substrates or pressure-dependent intrinsic doping. However, it has been reported that InAs nanowires
Survival after in-hospital pulseless electrical activity (PEA) cardiac arrest is poor and has not changed during the last 10 years. Effective chest compressions may improve survival after PEA. We investigated whether a mechanical device (LUCAS (TM)-CPR) can ensure chest compressions during cardiac arrest according to guidelines and without interruption during transport, diagnostic procedures and i
Luke’s account of the last supper (22:14–38) is here analyzed according to the pattern of chreia elaboration, which was one of the preparatory rhetorical exercises known as Progymnasmata in the Hellenistic school. The study begins with a brief overview of the preserved progymnastic textbooks or manuals and their contents, and then proceeds to show how influences from the exercises can be detected
Abstract in UndeterminedCrisis communication is a growing field of research and practice. A weakness in the traditional research field is the lack of theoretical development and the isolated sender and mass communication focus. In the present paper, we challenge traditional research by focusing on the contemporary cultural and ethnic diversity in society from an audience-oriented media perspective
According to the Euro-barometer conducted by European Parliament in 2016, 57% of Young People in Europe have the perception of being excluded from the society in their country of residence (EPRS, 2016). With rising of anti-immigrants sentiments across the globe and increasing discourse on failed integration, one of the most affected groups are young migrants (MUCF, 2016). Differently from existing
