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Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de
Until now, computationally designed enzymes exhibited low catalytic rates1, 2, 3, 4–5 and required intensive experimental optimization to reach activity levels observed in comparable natural enzymes5, 6, 7, 8–9. These results exposed limitations in design methodology and suggested critical gaps in our understanding of the fundamentals of biocatalysis10,11. We present a fully computational workflow
The concept of integrated risk management (IRM) has developed as a response to more interconnected and complex contexts. To investigate how the concept is used and what is meant with integration in the scientific literature, a research profiling was carried out across all kinds of risk management applications. 1094 publications from scientific journals, conference proceedings, and books were inclu
Background. Climate change is the greatest threat to human health in the 21st century and healthcare contributes to approximately 5% of global greenhouse gas emissions. Intensive and perioperative care are particularly resource intensive. This thesis aimed to assess the climate and environmental impacts of perioperative and intensive care (Papers I–III) and to explore how environmental outcomes an
Aim: To investigate the prevalence of eating and drinking difficulties as classified with the Eating and Drinking Ability Classification System (EDACS) in a large population-based cohort of children with cerebral palsy (CP) at all levels of motor function, and how EDACS classifications relate to undernutrition. Method: This was a cross-sectional study based on data from the Swedish CP follow-up pr
Bees play a key role in maintaining healthy terrestrial ecosystems by pollinating plants. Stingless bees (Apidae: Meliponini) are a diverse clade of social bees (>500 species) with a pantropical distribution spanning South and Central America, Africa, India, Australia and Asia. They are garnering increasing attention as commercially-beneficial pollinators of some crops, yet their contribution to t
Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SB
Background: Long-term consequences of posterior cruciate ligament (PCL) injury such as persistent posterior tibial translation and risk of osteoarthritis development are unclear. Additionally, little data is available describing the natural history of structural morphology of the ruptured PCL. The purpose of the study was to determine the long-term outcome after non-operatively treated PCL injury.
We report the real-valued static and complex-valued quasi-static anisotropic permittivity parameters of rare-earth scandate orthorhombic single crystal GdScO3 (GSO), TbScO3 (TSO), and DyScO3 (DSO). Employing continuous-wave terahertz spectroscopy (0.2-1 THz), the complex permittivity was extracted using an anisotropic ambient-film-ambient model. Data obtained from multiple samples of the same oxid
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and can lead to hepatocellular carcinoma (HCC), a leading cause of cancer-related death. We aimed to determine the extent to which MASLD is an increasing cause of HCC in Sweden and to determine clinical characteristics associated with underlying MASLD. Using the Swedish quality re
Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanism
BACKGROUND: Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.PATIENTS AND METHODS: We included 167 483 participants from two prospective US
Background: Cytotoxic lymphocytes are increased in the airways of COPD patients. Whether this increase is driven primarily by the disease or by smoking is not clear, nor whether it correlates with the rate of decline in lung function. Methods: Bronchoscopy with BAL was performed in 52 subjects recruited from the longitudinal OLIN COPD study according to pre-determined criteria; 12 with COPD and a
Specific ion (Hofmeister) effects in colloid and biological systems represented a scientific challenge for more than 100 years. Recently, possible applications, based on their rationalization, are emerging. Here, Cl-, SO42-, SCN- anions and Na+, K+, Mg2+ cations are added at physiological concentration (∼0.15 mol/kg) to Pluronic F127 20 wt% aqueous solutions to suitably tune phase transitions for
Few studies have investigated the offspring of women with anorexia nervosa (AN). The aim of this study was to examine perinatal status, mental and physical health in the offspring of mothers with a history of AN. Fifty-one individuals with adolescent-onset AN and 51 matched controls (COMP) have been followed prospectively. Presently, 30 years after AN onset, at a mean age of 44 years, female parti
Externally bonded fiber-reinforced polymer (FRP) plates or sheets have become a common retrofitting approach for sustaining old reinforced concrete structures in the modern era. The capacity of FRP-strengthened structures cannot be accurately estimated because the bond strength between FRP and concrete surface is accurately unpredictable. Various studies are available in the literature to predict
Popular Abstract in Swedish Hur är grannsämjan i skånska vattendrag?
Grönling, öring och signalkräfta är tre vanligt förekommande arter i rinnande vatten i Skåne. Öringens biologi och ekologi är väl undersökta och den är dessutom en populär sportfisk. Signalkräftan inplanterades i slutet på 1960-talet för att ersätta den inhemska flodkräftan och är även den ekonomiskt viktig, samt Stream ecosystems are dynamic and they have an inherent environmental variability. Organisms that live in streams are adapted to the continuously changing environment and the presence or absence of species are determined by their environmental requirements, while abundance is most often affected by interactions, such as competition and predation, with other species that are found in the same habit
Organic farming, considered as an agricultural practice, is supported by the CAP as an initiation for promoting environmental friendly method. The CAP supports the growth of a consumer-driven organic market. Organic farming is a sustainable practise that benefits the environment; market supports economic growth and society benefits in terms of health and quality of food. A large number of Swedish
Det är viktigt att det i ett land finns rättssäkerhetsgarantier. För svensk del är Europeiska konventionen angående skydd för de mänskliga rättigheterna och de grundläggande friheterna en väldigt viktig utgångspunkt. I min framställning har jag studerat vilka krav konventionen ställer på rätten till en domstolsprövning och en rättssäker process, art 6 i Europakonventionen. Med dessa krav i bakhuvuLegal certainty is important in every country. For the Swedish part the European Convention on Human Rights and Fundamental Freedoms is a very important starting point and framework. In my presentation, I have studied the requirements that the Convention imposes on the access to court and the entitlement to a fair and public hearing, art 6 of the Convention. With these requirements in mind, I look
As people travel more than ever before, transport and infrastructure is growing in all Swedish cities. With growing emission levels of nitrogen dioxide, greenhouse gases and particles, and an increasing risk of traffic-related accidents, parking strategy is a key component in planning and securing the healthy development of the city's infrastructure. For new construction and rebuilding a parki
