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A multicenter, open-label, randomized efficacy and safety study was performed with combined human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) (Puregon(R)) treatment to induce spermatogenesis in hypogonadotropic hypogonadal male patients. Patients were pretreated for 16 weeks with hCG to normalize testosterone levels. A total of 30 of 49 (61%) subjects had nor

Background: Many clinical trials with omalizumab, Xolair, have been reported but the treatment period has always been short, i.e. < 12 months. After withdrawal, the clinical symptoms tend to return. A group of patients who stopped treatment after approx. 6 years allowed studies of the long-term effects of Xolair. Methods: The patient's cat or mite allergen sensitivity was quantitated as basophil a

Aim. To measure levels of anxiety among people accompanying consumers to the emergency department and to explore how anxiety influences satisfaction with care. Background. When people seek treatment in an emergency department they are often accompanied by a next-of-kin, family member or friend. While the accompanying person plays a vital role in providing psycho-social support to consumers, little

Background and Purpose - Depression after stroke is often described as underdiagnosed and undertreated. However, there are few data on self-reported depression and use of antidepressants in stroke patients at large. Materials and Methods - In the Swedish national quality assessment register, Riks-Stroke, 15 747 stroke survivors are recorded. They were asked about depressive mood and antidepressant

Biogeochemical silicon (Si) cycling in coastal systems is highly influenced by anthropogenic perturbations in recent decades. Here, we present a systematic study on the distribution of stable Si isotopes of dissolved silicate (δ30SiDSi) in a highly eutrophic coastal system, the Baltic Sea. Besides the well-known processes, diatom production and dissolution regulating δ30SiDSi values in the water c

Background Whole-genome sequencing (WGS) of heart transplant recipient- and donor-derived cardiac biopsies may facilitate organ matching, graft failure prediction, and immunotolerance research. The objective of this study was to determine the feasibility of WGS based on formalin-fixed paraffin-embedded endomyocardial biopsies. Methods and results The study included serial donor- and recipient samp

SMAA35, Digital Service Management Schedule SMAA35 2018-08-29 - 2019-02-24 SMAA35, Digital Service Management Time Rooms* Tuition type Staff w36 Tue 2018-09-04 10:00 - 12:00 3T C218 Lecture Richard Ek Wed 2018-09-05 13:00 - 15:00 3T C218 Information Eerika Saaristo Thu 2018-09-06 10:00 - 12:00 3T C218 Lecture Johan Alvehus w37 Tue 2018-09-11 14:00 - 16:00 3T C164 Compulsory, Seminar Richard Ek Wed

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/schedule_smaa35_preliminary.pdf - 2026-05-30

BACKGROUND: Cognitive fatigue after childhood cancer is frequently overlooked despite guidelines recommending follow-up, and might be mistaken for depression due to overlapping symptoms. Our objectives were: 1) to examine ratings of fatigue in survivors of paediatric brain tumours (BT) and acute lymphoblastic leukaemia (ALL) compared to healthy controls, 2) to examine the relationship between symp

Background: There has been an increasing number of single-centre studies describing the long-term outcomes of patients with Hirschsprung disease. This study aimed to systematically review the literature on long-term bowel, urological, and sexual functional outcomes, fertility and quality of life in adults with Hirschsprung disease. Methods: A PROSPERO-registered systematic review of the English li

Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f

Microsoft Word - Light sheet microscope report 2019.docx Light sheet microscope 1. Short description of the platform The lightsheet microsope was purchased 3 years ago, financed jointly by Multipark, Bagadilico and StemTherapy, and it is now run as a technical platform, owned by two-thirds by Multipark and one-third by StemTherapy. The LSM platform is available for all members of Multipark and Ste

https://www.multipark.lu.se/sites/multipark.lu.se/files/light_sheet_microscope_report_2019_.pdf - 2026-05-30

GOALS: To assess the incidence, type, and severity of infections in patients with IBD before and after starting thiopurine therapy.BACKGROUND: Thiopurines have been used for decades in the treatment of inflammatory bowel disease (IBD), yet real-world data regarding the extent and types of infections associated with their use are scarce.STUDY: We included all thiopurine-naive adults with IBD who in

Annual report_2016_IIIEE_.pdf ADVANCING SUSTAINABLE SOLUTIONS ANNUAL REPORT 2016 The IIIEE by numbers in 2016 Publications 44 37 Masters students 93 on campus (147 on campus and distance) Masters graduates 850+ people from 90+ countries (21 researchers, 11 PhD students, 9 administration, guest researchers) Staff 40+ Participants in MOOCs 52,500 56,000 Research projects 30 (137,000 in total) Downlo

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/annual_report_2016_iiiee_web_version.pdf - 2026-05-30

The novel wrought nickel-based superalloy, AD 730™, is a good candidate material for turbine disc applications at high temperatures beyond 650 °C. The present study focuses on the machining performance of this newly developed alloy under high-speed turning conditions with advanced PCBN tools. Meanwhile, the machined surface integrity as influenced by cutting speed and feed rate was also investigat

Background: Predicting a challenging clot when performing mechanical thrombectomy in acute stroke can be difficult. One reason for this difficulty is a lack of agreement on how to precisely define these clots. We explored the opinions of stroke thrombectomy and clot research experts regarding challenging clots, defined as difficult to recanalize clots by endovascular approaches, and clot/patient f

PURPOSE: To explore if aspects of the physical home environment are related to rehabilitation outcomes among community-living persons poststroke.BACKGROUND: Research demonstrates that healthcare environments are important for high-quality care and that the design of the physical environment is associated with improved rehabilitation outcomes. However, relevant research focusing on outpatient care

Conifer-feeding bark beetles are important herbivores and decomposers in forest ecosystems. These species complete their life cycle in nutritionally poor substrates and some can kill enormous numbers of trees during population outbreaks. The Eurasian spruce bark beetle (Ips typographus) can destroy >100 million m3 of spruce in a single year. We report a 236.8 Mb I. typographus genome assembly usin

Background: Adjuvant chemotherapy (ACT) for breast cancer improves relapse-free survival (BCRFS) and overall survival. Differences in terms of efficacy and toxicity could partly be explained by the significant interpatient variability in pharmacokinetics which cannot be captured by dosing according to body surface area. Consequently, tailored dosing was prospectively evaluated in the PANTHER trial

Background Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation. Objective We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia

Background: Obesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail. Methods: Data from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austr