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A Saccharomyces cerevisiae screening strain was designed by combining multiple genetic modifications known to improve xylose utilization with the primary objective of enhancing xylose growth and fermentation in xylose isomerase (XI)-expressing strains. Strain TMB 3045 was obtained by expressing the XI gene from Thermus thermophilus in a strain in which the GRE3 gene coding for aldose reductase was
The enzyme beta-galactosidase was purified from a cold-adapted organism isolated from Antarctica. The organism was identified as a psychrotrophic Pseudoalteromonas sp. The enzyme was purified with high yields by a rapid purification scheme involving extraction in an aqueous two-phase system followed by hydrophobic interaction chromatography and ultrafiltration. The beta-galactosidase was optimally
The neutron beam at the Studsvik facility for boron neutron capture therapy (BNCT) and the validation of the related computational model developed for the MCNP-4B Monte Carlo code are presented. Several measurements performed at the epithermal neutron port used for clinical trials have been made in order to validate the Monte Carlo computational model. The good general agreement between the MCNP c
To investigate a possible time trend in serum concentrations of persistent organochlorine pollutants (POPs), representative samples of the young (median age 18 years) Swedish male population were investigated in the years 2000 and 2004. Due to their low age, these men were assumed not to have reached steady state of body burdens of POPs, why their serum concentrations were considered to represent
The clinical background and circumstances of 75 patients who had survived a near-fatal choking episode, i.e., had undergone a Heimlich maneuver, oropharyngeal suctioning, or intubation, is reported. Sixty had choked on a solid bolus (often of a complex texture like sandwiches and chicken soup). Four patients had choked on mashed banana. In 30 patients neurologic disease (such as cerebrovascular di
Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scruti
Learning disability is common, affecting 1-2.5% of the general population in the Western world, and encompasses many different conditions. It usually leads to major functional impairment and lifelong need for support and interventions, not the least important of which are medical and health-care services. Rapid progress is being made in the understanding of the cause and pathogenesis of many learn
The Van (forest) Gujjars, surviving as forest pastoralists in the central part of the Indian Himalaya, are a people who, due to their nomadic lifestyle, have since colonial rule found themselves at the margin of Indian society. This paper will look at the relationship between the Van Gujjars and their forest base in a historical perspective from colonial rule to 'conservation of nature' and the 'r
Microbial enzyme diversity is a key to understand many ecosystem processes. Whole metagenome sequencing (WMG) obtains information on functional genes, but it is costly and inefficient due to large amount of sequencing that is required. In this study, we have applied a captured metagenomics technique for functional genes in soil microorganisms, as an alternative to WMG. Large-scale targeting of fun
By having phenotypically plastic traits, many organisms optimize their fitness in response to fluctuating threats. Freshwater snails with translucent shells, e.g. snails from the Radix genus, differ considerably in their mantle pigmentation patterns, with snails from the same water body ranging from being completely dark pigmented to having only a few dark patterns. These pigmentation differences
Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at
A gardener in Småland, southeastern Sweden, tells that her father cultivated a double daylily, Hemerocallis fulva, with variegated leaves in Stockholm in the mid 20th century. When she moved to Småland, 45 years ago, she brought a piece of his plant with her, and later on she has spread the plant to others. This daylily, known as "Kwanso Variegata", was first found in Japan in 1776, and since then
Banker har en essentiell roll i det moderna samhällssystemet funktion som betalningsförmedlare, kreditgivare och mottagare av ekonomiska medel från allmänheten som placeras till exempel på konto i bank. Utan ett fungerande banksystem blir möjligheten för företag och privatpersoner att förmedla betalningar till varandra, söka krediter eller förvara sina intjänade medel på ett tryggt sätt starkt bFinancial companies in general, and banks in particular, plays an essential role for the function of modern society. Without a working banking-system there would be no effective way to make payments and hardship would meet the credit-market. Some banks have been thought of as ”to big to fail”, although during the last years well-known international banks such as Leeman Brothers has been forced t
The aim of the current study was to gain an overview of factors that can effect social secretaries motivation, both positively and negatively, in their work with social assistance. This study has focused on what the employee does rather than what he or she earns as a factor that leads to increased work motivation. To have motivated employees are important in every organization and above all in Hum
Severe droughts in the Northern Hemisphere cause a widespread decline of agricultural yield, the reduction of forest carbon uptake, and increased CO2 growth rates in the atmosphere. Plants respond to droughts by partially closing their stomata to limit their evaporative water loss, at the expense of carbon uptake by photosynthesis. This trade-off maximizes their water-use efficiency (WUE), as meas
OBJECTIVES: To examine patient willingness and possible shift in willingness for surgery and to investigate factors associated with this shift, following participation in the digital non-surgical osteoarthritis (OA) treatment program Joint Academy.METHODS: 458 individuals (mean age 62±5.6 years, 67% women) with diagnosed hip or knee were evaluated after six weeks in Joint Academy, comprising educa
BACKGROUND: People with psychiatric disability have been found to have a poorer quality of life (QOL) compared to the general population, and QOL is an important outcome from psychosocial rehabilitation. AIMS: This study aimed at comparing users of two approaches to psychosocial rehabilitation in Sweden, community-based mental health day centres (DCs) and clubhouses, regarding QOL. A further aim w
Dissolved Organic Carbon (DOC) is a key component of the inland water carbon cycle, playing a critical role in water quality, aquatic ecosystem dynamics, and carbon flux assessments. In this study, we combine Sentinel-2 Multi-Spectral Instrument (MSI) data with in-situ water quality, meteorological, and temporal variables to predict DOC concentrations in Lake Erken, Sweden. Three Machine Learning
BACKGROUND: Brief admission by self-referral, a novel crisis intervention designed to reduce suicide and self-harm in adults, was adopted for adolescents in paediatric psychiatry in Malmö, Sweden, in 2018. We aimed to investigate changes in utilisation of emergency psychiatric care.METHODS: We did an observational longitudinal cohort study in The University Hospital in Malmö, Sweden, which provide
