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Purpose: The purpose of this work was to explore the possibility to compare treatment-planning- and treatment-delivery systems for intensity modulated radiation therapy (IMRT) using an objective approach. The approach investigated was the Pareto front concept. An additional aim was to adequately compare three different IMRT treatment planning and delivery systemsMaterials and methods: In IMRT trea
Context:TSH-secreting pituitary adenomas (TSHomas) are rare. Epidemiological data are scant and there are no reports on national incidence.Objective:The objective of the study was to estimate the national Swedish incidence and prevalence of TSHomas.Design:This was an observational study.Setting:The study was conducted at tertiary referral centers.Patients:The Swedish Pituitary Registry and World H
BACKGROUND: /st>The relative respiratory effects of fentanyl and remifentanil, administered as i.v. bolus, have not previously been studied. We determined what remifentanil bolus dose gave the same maximum depression of ventilation as 1 µg kg(-1) of fentanyl. METHODS: /st>Twelve healthy volunteers rebreathed in a system designed to dampen variations in end-tidal carbon dioxide tension so that me
IMPORTANCE Diurnal fluctuations of motor and nonmotor symptoms and a high prevalence of sleep-wake disturbances in Parkinson disease (PD) suggest a role of the circadian system in the modulation of these symptoms. However, surprisingly little is known regarding circadian function in PD and whether circadian dysfunction is involved in the development of sleep-wake disturbances in PD. OBJECTIVE To d
High-altitude lakes and headwater streams of the Andes provide essential benefits to society, yet they remain among the least studied and most vulnerable freshwater ecosystems. These systems supply drinking water, support agriculture and grazing, regulate floods, store carbon, and hold deep cultural and spiritual value for local communities. However, climate change, land use change, water extracti
UV irradiation is getting increasingly popular as a disinfection step in drinking water production. Ringsjöverket, a drinking water treatment plant in Sweden installed a full-scale UV aggregate in December 2016. However, the effect of UV irradiation on drinking water has mainly been tested on specific pathogens in labscale environment. Heterotrophic plate counts are often used when analyzing drink
Penningtvätt har länge varit ett uppmärksammat problem, men inte förrän på senare år, särskilt efter den 11 september 2001 och terroristattackerna i USA har stora krafttag gjort att bekämpningen av problemet kommit igång. Bekämpningen och förhindrandet av penningtvätt och finansiering av terrorism är även viktigt utifrån ett större perspektiv. Om man kan strypa finanserna för kriminell verksamhet,Money laundering has for a long time been an acknowledged problem, now more than ever. Especially after 9/11 2001 and the terrorist attacks in the USA, joint efforts have made combating the problem a serious matter. Combating and prevention of money laundering and terrorism financing is also important from a larger perspective. If you can close off finances of criminal activity, you are one step c
Introduction: The aim was to study if the evaporative water loss can be predicted enough accurately for hydration recommendations by ISO 7933 – Predicted Heat Strain (PHS) model during a student laboratory exercise in an extremely hot environment.Method: Twelve young healthy students (8 males and 4 females), unacclimatized to heat, were exposed in a climatic chamber at 50˚C, 30% relative humidity
Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and C-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female GIP recep
Background: Patients with reduced renal function may be at risk of contrast medium-induced acute kidney injury (CI-AKI) following intravenous iodine contrast medium (CM) enhanced computed tomography (CT). Reducing the CM dose may reduce this risk. Decreasing the X-ray tube potential (kilovoltage, kV) from commonly used 120 to 80 kV results in higher CM attenuation due to the photoelectric properti
Introduction: The aim of this study was to investigate the 1986-1994 trend in obesity, overweight and sedentary leisure-time physical activity status, and the educational gradient in overweight and obesity in the city of Malmö, Sweden. Material/Methods: The public health surveys in Malmö 1986 and 1994 are cross-sectional studies. A total of 4,800 and 5,600 individuals aged 20–80 years were randoml
Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present study aimed at identification of genetic factors determining progranulin concentrations. We conducted a genome-wide association meta-analysis for serum progranulin in three independent cohorts from Europe: Sorbs (N=848) and KORA (N=16
Abstract BACKGROUND: Most individuals with Helicobacter pylori infection in Western countries have no evidence of peptic ulcer disease (PUD). We therefore assessed the PiZ deficiency variant of the major plasma protease inhibitor alpha1-antitrypsin (alpha1AT) as a risk factor for PUD in H. pylori-infected individuals. METHODS: The cohort comprised 100 patients with endoscopically or surgically pr
Background: Hip pain is prevalent in children with cerebral palsy (CP). Hip displacement is a known risk factor for hip pain. However, many children do not have displaced hips but still have hip pain and the aetiologies are poorly understood. The aims of this study were to investigate: 1. the prevalence of hip pain related to age, gender, gross motor function, degree of hip displacement and 2. the
Orchids have minute, air-filled seeds and are considered as efficient dispersers and colonizers. Yet, empirical studies show that most seeds fall within the nearest metre from the mother plant in orchids, and that individuals standing close to each other are often closely related. A poor contribution to gene dispersal by seeds may be compensated for by more efficient dispersal by pollen, but in auOrchids have minute, air-filled seeds and are considered to be efficient dispersers and colonizers. However, empirical studies show that most seeds fall within a metre of the mother plant in orchids, and that individuals standing close to each other are often closely related. A poor contribution to gene dispersal by seeds may be compensated for by more efficient dispersal by pollen, but in autogam
Purpose: In response to the need for hearing aids in low-income countries, an approach to provide hearing aids through trained community workers was developed. This study compares the effectiveness of the community-based approach with that of a centre-based approach. Methods: One hundred and forty adolescents (56% girls; 12–18 years; mean: 15 years) from eleven sub-districts participated in a clus
Purpose: This study aimed to evaluate the association of socioeconomic status and comorbidities with uncomplicated and complicated diverticular disease (DD) in Sweden. Methods: We identified all individuals aged ≥30 years in Sweden diagnosed with DD between 1997 and 2012 using the Swedish National Population and Housing Census and the Hospital Discharge Register. Data were analyzed by multivariabl
In connection with the Chernobyl fallout and the subsequent deposition of radionuclides in Sweden, Swedish municipalities launched a measurement program to monitor the external radiation exposure. This program encompasses measurements of the ambient dose equivalent rate 1 m above ground at selected locations, and repeats those measurements at the same locations at 7-month intervals. Measurement da
BACKGROUND: Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels of physical activity is common during periods of hospitalization and leads to functional decline as well as increased risk of complications. The aim of this study is to assess the effect of supervised physical training during hospitalization with CAP compared with standard usual
Background: Troponin elevation is frequently observed in various scenarios in the Emergency Department (ED), yet there is a paucity of studies investigating simultaneously measured high-sensitivity cardiac troponin T (hs-cTnT) and troponin I (hs-cTnI) within a diverse cohort in a clinical setting. Methods: All patients who underwent troponin testing at a single center were eligible for this study.
