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INTRODUCTION: Worsening renal function (WRF) is associated with poor prognosis in patients with heart failure (HF). Osteopontin (OPN) and Matrix extracellular phosphoglycoprotein (MEPE) are expressed in the kidneys and are involved in bone mineralization processes. Higher OPN levels have been associated with a higher risk for adverse outcomes in patients with chronic kidney disease (CKD), and MEPE

Background: The number of pregnant women with congenital heart disease (CHD) is rising, and the disease poses increased risks of cardiovascular and obstetric complications during pregnancy, potentially impacting breastfeeding success. This study aimed to investigate breastfeeding in primiparous women with CHD compared to primiparous women without CHD, and to examine potential hindering factors for

The neutron beam at the Studsvik facility for boron neutron capture therapy (BNCT) and the validation of the related computational model developed for the MCNP-4B Monte Carlo code are presented. Several measurements performed at the epithermal neutron port used for clinical trials have been made in order to validate the Monte Carlo computational model. The good general agreement between the MCNP c

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.

A Saccharomyces cerevisiae screening strain was designed by combining multiple genetic modifications known to improve xylose utilization with the primary objective of enhancing xylose growth and fermentation in xylose isomerase (XI)-expressing strains. Strain TMB 3045 was obtained by expressing the XI gene from Thermus thermophilus in a strain in which the GRE3 gene coding for aldose reductase was

Objectives Exposure to aluminium compounds, such as fluorides in gaseous and particulate form, places people who work in potrooms at risk for respiratory symptoms. Workers in potrooms, however, also are exposed to a number of other air contaminants. In this study, we present the first report of a dose-response relationship after exposure to potassium aluminium tetrafluoride (KAlF4) and the influen

Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at

PURPOSE: As a prelude to developing updated, evidence-based, international consensus recommendations for the management of hip and knee osteoarthritis (OA), the Osteoarthritis Research Society International (OARSI) Treatment Guidelines Committee undertook a critical appraisal of published guidelines and a systematic review (SR) of more recent evidence for relevant therapies. METHODS: Sixteen exper

Advances in next-generation RNA-sequencing have revealed the complexity of transcriptomes by allowing both coding and noncoding (nc) RNAs to be analyzed. However, limited data exist regarding the whole transcriptional landscape of chronic lymphocytic leukemia (CLL). In this pilot-study, we evaluated RNA-sequencing in CLL by comparing two subsets which carry almost identical or `` stereotyped'' B-c

Background Gadolinium (Gd) neutron capture therapy (GdNCT) is based on a neutron capture reaction (NCR) that involves emission of both short and long range products. The aim of this study was to investigate both the microscopic and macroscopic contributions of the absorbed dose involved in GdNCT. Methods Cylindrical containers with diameters 1-30 mm filled with a solution of Gd were irradiated wit

The objective was to investigate which screening variables in a population study predicted carotid endarterectomy. Among 793 carotid endarterectomies performed at Malmo University Hospital between 1991 and 1998, 85 patients (14 females) were identified that had participated in a population screening between 1974 and 1991. Median time from screening to operation was 16 years (range 6-26 years). Scr

We analyzed 37 primary invasive carcinomas for BRCA1 and BRCA2 mutations by screening the entire coding regions of both genes. Seven predicted truncating mutations (four in BRCA1 and three in BRCA2) and one novel BRCA1 missense variant (S1542C) were identified (8/37, 22%). Two of the BRCA1 mutations were somatic changes, whereas the remaining three BRCA1 changes and all mutations of BRCA2 were fou

För många människor är förmodligen fastighetsköpet en av de största affärerna de någonsin kommer att genomföra och det är således viktigt att det blir som de tänkt sig. Det är inte alls säkert att en presumtiv köpare kalkylerat för eventuella brister i fastigheten i sin budget och upptäcks då ett fel efter köpet kan köparen hamna i en mycket komplicerad situation. Vid varje fastighetsaffär finnsFor a lot of people, the real property purchase is probably one of the most important business deals they will ever do and therefore it is important that the property will be as they have expected. It´s not certain that the purchaser has calculated in his budget for defects in the property. If the purchaser later discovers a defect in the property, he may end up in a very complicated situation. I

UV irradiation is getting increasingly popular as a disinfection step in drinking water production. Ringsjöverket, a drinking water treatment plant in Sweden installed a full-scale UV aggregate in December 2016. However, the effect of UV irradiation on drinking water has mainly been tested on specific pathogens in labscale environment. Heterotrophic plate counts are often used when analyzing drink

The aim of the study has been to examine how young men describe training habits, eating habits and good health. In order to achieve this, six qualitive semistructured interviews were held with six men between the age of 20-30 who are practising or have been practising some sort of exercise. The interview contained questions regarding training habits, eating habits and view of good health, but also

Det svenska straffrättsliga systemet bygger på att endast fysiska personer kan begå brott och straffas för dessa. För näringsidkare, såväl fysiska som juridiska personer, har det istället införts särskilda sanktioner såsom företagsbot. Någon särskild reglering av företagsbotsprocessen och näringsidkarens processuella rättigheter vid en talan om företagsbot har däremot inte införts. Samtidigt uppstThe Swedish criminal justice system is based on the fact that only physical persons can commit crimes and be punished for them. For traders, both physical and legal persons, special sanctions such as a corporate fine have been introduced. However, no special regulations of neither the corporate fine procedure nor the procedural rights for traders, when pursuing criminal charges of a corporate fine

Familjeåterförening är en viktig princip inom både svensk och internationell rätt. I svensk rätt regleras denna princip i utlänningslagen där en möjlighet till uppehållstillstånd på grund av anknytning ges. Vissa bevisrättsliga frågor måste dock uppfyllas för att uppehållstillstånd ska kunna ges. I denna framställning behandlas bevisning angående ställföreträdarskap för barn som söker uppehållstilFamily reunification is an important principle in both Swedish and international law. In Swedish law this principle is coded into the Aliens Act making it possible to get residence permit on the grounds of ties to Sweden. In order to get a residency permit there are a couple of things you have to prove, for example your identity and the existence of a relation to a person in Sweden. If you are und

Penningtvätt har länge varit ett uppmärksammat problem, men inte förrän på senare år, särskilt efter den 11 september 2001 och terroristattackerna i USA har stora krafttag gjort att bekämpningen av problemet kommit igång. Bekämpningen och förhindrandet av penningtvätt och finansiering av terrorism är även viktigt utifrån ett större perspektiv. Om man kan strypa finanserna för kriminell verksamhet,Money laundering has for a long time been an acknowledged problem, now more than ever. Especially after 9/11 2001 and the terrorist attacks in the USA, joint efforts have made combating the problem a serious matter. Combating and prevention of money laundering and terrorism financing is also important from a larger perspective. If you can close off finances of criminal activity, you are one step c

Rätten att få använda straffprocessuella tvångsmedel är viktig och nödvändig för de brottsutredande myndigheterna för att uppnå så effektiv brottsbekämpning som möjligt. Exempel på typiska straffprocessuella tvångsmedel är häktning, anhållande samt husrannsakan, alla innebär en integritetskränkning för den som utsätts för de. När det gäller hemliga tvångsmedel är de att anse som mer integritetskräThe right to use pre-trial coercive measures is important and necessary for the investigating authorities in the objective of achieving the most effective law enforcement possible. Examples of typical criminal coercive measures are detention, arrest and raids, all of which violate the privacy of the victim. Examples of secret coercive measures are secret telemonitoring and secret telephone tapping

Spx or why bacteria don’t suffer from burnout Bacteria also suffer from stress. In general, any fluctuation in the environment of bacteria can cause stress on them. For instance, too hot or too cold temperature, or changes in the pH. In order to survive, they need mechanisms to cope with it. Most of these mechanisms involve proteins, which can be seen as tools that respond to stress. In the bac