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We introduce rigorous theory for deriving first and second order backpropagation methods for Deep Neural Networks (DNN) whilst satisfying existing theory in DNN optimization. We begin by formally defining a neural network with its respective components and state the first and second order chain rule with respect to its partial derivatives. The partial derivatives in the chain rule formula are rela
In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses
Background: Helicobacter pylori causes peptic ulcer disease and gastric cancer, and the oral cavity is likely to serve as a reservoir for this pathogen. We investigated the binding of H. pylori to the mucins covering the mucosal surfaces in the niches along the oral to gastric infection route and during gastric disease and modeled the outcome of these interactions. Materials and Methods: A panel o
Protein C inhibitor (PCI) is a serine protease inhibitor, displaying broad protease specificity, found in blood and other tissues. In blood, it is capable of inhibiting both procoagulant and anticoagulant proteases. Mechanisms that provide specificity to PCI remain largely unrevealed. In this study we have for the first time provided a full explanation for the marked size heterogeneity of blood-de
Homozygous C2 deficiency (C2D) is the most common deficiency of the classical complement pathway in Western countries. It is mostly found in patients with autoimmune disease or susceptibility to bacterial infections and in healthy persons. We wished to assess to what extent other immunological factors might explain differences of susceptibility to infections in C2D. For this reason, 44 Swedish pat
In this study, we report on reactive large-eddy simulations (LESs) of flow and combustion in the U.S. Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves the combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques, including particle image velocimetry, hyperspectral imagining, and l
Massive Multiple-Input Multiple-Output (MIMO) communication systems are being investigated intensively for positioning services. Enhancing the accuracy on these services in terms of accurate positioning of users is an important goal to improve related applications in the future. Convolutional Neural Networks (CNNs) has been proposed to infer the position of a user from Channel State Information (C
An evaluation has been made of the capability of rapeseed oil to dissolve polycyclic aromatic hydrocarbon (PAH) crystals in a biphasic system and of its capability to extract PAHs from polluted soil in a two-liquid-phase (TLP) slurry system. Up to 220 g l(-1) of the crystalline hydrocarbons could be dissolved in the organic phase, indicating oil/water-partitioning coefficients of 10(5). When soil
Freshwaters bring a notable contribution to the global carbon budget by emitting both carbon dioxide (CO2) and methane (CH4) to the atmosphere. Global estimates of freshwater emissions traditionally use a wind-speed-based gas transfer velocity, kCC (introduced by Cole and Caraco, 1998), for calculating diffusive flux with the boundary layer method (BLM). We compared CH4 and CO2 fluxes from BLM wit
Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei
pedi_774.dvi Pediatric Diabetes 2011 doi: 10.1111/j.1399-5448.2011.00774.x All rights reserved © 2011 John Wiley & Sons A/S Pediatric Diabetes Original Article The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants Hagopian WA, Erlich H, Lernmark Å, Rewers M, Ziegler AG, Simell O, Akolkar B, Vogt Jr R, Blair A
https://www.teddy.lu.se/sites/teddy.lu.se/files/06032016_679_13_hagopian_ped_diab_2011.pdf - 2026-06-23
Popular Abstract in Swedish Trots ny fordonsteknik så har koldioxidutsläppen ökat med nästan 40% i Europa sedan 1990-talet. Detta beror främst på en tilltagande transport på våra vägar. Drivmedel som används inom transportsektorn är nästan uteslutande diesel och bensin, vilka härstammar från fossila bränslen. För att hantera konsekvenserna av transportfordons miljöpåverkan så blir lagstiftningen p
Lunds universitet i världsklass Hamburg June 4-5 2009 Workshop on Critical Period(s) and successive acquisition in childhood Cliticisation in the Acquisition of Child French L2: a Cross-Learner Comparison Jonas Granfeldt Lund University jonas.granfeldt@rom.lu.se Hamburg June 4-5 2009 Workshop on Critical Period(s) and successive acquisition in childhood Outline INTRODUCTION The project Hypothesis
