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Background and ObjectivesIntestinal levodopa/carbidopa gel infusion (LCIG) is superior to oral treatment in advanced Parkinson disease. The primary objective of this trial was to investigate whether continuous subcutaneous or intravenous infusion with a continuously buffered acidic levodopa/carbidopa solution yields steady-state plasma concentrations of levodopa that are equivalent in magnitude, a
Taking advantage of Estonia's small size and population, we have employed wastewater-based epidemiology approach to monitor the spread of SARS-CoV-2, releasing weekly nation-wide updates. In this study we report results obtained between August 2020 and December 2021. Weekly 24 h composite samples were collected from wastewater treatment plants of larger towns already covered 65% of the total popul
Background: Birds have extremely elevated metabolic rates during migratory endurance flight and consequently can become physiologically exhausted. One feature of exhaustion is oxidative damage, which occurs when the antioxidant defense system is overwhelmed by the production of damaging reactive oxygen species (ROS). Migrating birds have been shown to decrease the amount of oxidative lipid damage
BACKGROUND: Malignant melanoma is the most deadly form of skin cancer. Female sex is known to have a protective effect on incidence, tumour characteristics, and mortality from melanoma. However, the potentially modifying effect of sex on the prognostic significance of clinicopathological and investigative factors is generally not taken into consideration in biomarker studies. In this study, we com
Denna avhandling handlar om kapitalistisk stadsförnyelse och regleringen av bostadsfattigdom i Mumbai. Avhandlingen undersöker hur stadsutvecklingsregimer formar omflyttningar och styrning av befolkningen i Mumbai. Författaren använder etnografiskt utforskande av två storskaliga projekt: transportexpansion och pipelinesäkerhet samt två omlokaliserade samhällen och deras socio-politiska dynamik på This dissertation concerns capitalist urban redevelopment and the government of urban housing poverty. It examines the ways urban redevelopment regimes shape resettlements and governance of urban populations in Mumbai. The specific enquiries focus on salient accumulative and dispossessive dimensions of urban redevelopment and linked resettlement construction, the reformation of informal politics o
For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop
The maintenance of protein homeostasis, also referred to as proteostasis, is essential for preserving the structural and functional stability of the proteome in living organisms. This involves the precise control of protein synthesis, folding, and degradation. As proteostasis disruption can cause growth and survival deficiencies in bacteria, the investigation of proteostasis has rapidly emerged as
Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. The thesis evaluates the effect of radiolabelling chemistry on biodistribution and targeting properties of Affibod
High resolution observations with ALMA have revealed that concentric rings and gaps are common features in protoplanetary disks. The favored mechanism for creating these substructures are planet-disk interactions, in which growing planets open gaps in the disk, and particles become trapped at the pressure maxima that form at the corresponding gap edges. Since the particle density in these pressure
During migratory endurance flights, which are energetically very demanding, migrants have to deal with prolonged elevated generation of reactive oxygen species (ROS). To limit the damaging actions that ROS have on lipids and proteins, migrating birds are known to upregulate their antioxidant defence system. However, there may be additional ways to limit oxidative damage incurred from flying. Migra
Our overall understanding of long-term climate dynamics is largely based on proxy data generated from archives such as ice cores, ocean sediments, tree rings, speleothems, and corals, whereas reconstructions of long-term changes in vegetation and associated climate during the Holocene are largely based on paleoecological records from peat and lake sequences, primarily pollen and plant macrofossil
Introduction: Uncertainty in the dose-response of low dose radiation raised concern of an increased cancer incidence in Sweden after the Chernobyl Nuclear Power Plant (NPP) accident. Material and methods: A closed cohort was created of all males ≥18 years of age living in the Northern Sweden in 1986. In total 826,400 individuals were enrolled including 40,874 hunters. A nested case-control design
In this study, we modeled the aerosol particle formation along air mass trajectories arriving at the remote Arctic research stations Gruvebadet (67 m a.s.l.) and Zeppelin (474 m a.s.l.), Ny-Ålesund, during May 2018. The aim of this study was to improve our understanding of processes governing secondary aerosol formation in remote Arctic marine environments. We run the Lagrangian chemistry transpor
Eurasian spruce bark beetle, Ips typographus is a destructive pest of the Norway spruce (Picea abies). Recent outbreaks in Europe have been attributed to global warming and other anthropogenic impacts. Bark beetles are guided by multiple complex olfactory cues throughout their life cycle. Male-produced aggregation pheromones, comprising 2-methyl-3-buten-2-ol and cis-verbenol, have been identified
Aim: The aim was to identify the primary drivers of compositional change in breeding bird assemblages over a 40-year period. Location: Britain. Time period: From 1970 to 2010. Major taxa studied: Birds. Methods: Using morphological trait measurements and a dataset of presence–absence data for British breeding birds surveyed in 10 km × 10 km hectads during two time periods, we calculated temporal t
Process-based forest models combine biological, physical, and chemical process understanding to simulate forest dynamics as an emergent property of the system. As such, they are valuable tools to investigate the effects of climate change on forest ecosystems. Specifically, they allow testing of hypotheses regarding long-term ecosystem dynamics and provide means to assess the impacts of climate sce
We live in an era that suffers from climate change issues, not least disaster risks induced by climate change. While measures, such as proper evacuation plans, are required to reduce the negative impacts of disasters when they hit, actions should also be taken to reduce climate change effects by e.g. increasing the use of renewable energies or proper urban land-use allocation, where climate change
