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Background: The Southern Swedish Malignant Melanoma (SSMM) research team is a truly cross functional group with members from oncology, clinical, surgery, bioinformatics, proteomics, and genomics initiatives. The SSMM’s objectives and goals are to develop, build and utilize cutting edge biobanks and OMICS platforms to better understand disease pathology and drug mechanisms. Within the research team
Amorphous Silica (ASi) is present in considerable amounts in most soils and serves as a (micro-)nutrient for many plants. However, our understanding of the response of this important nutrient pool to human or natural disturbances is still very limited. One of the reasons for this is the long time scales involved. This explorative study focuses on the effect of a historical agricultural system, cal
Popular Abstract in Swedish Denna sammanläggningsavhandling i fysisk planering visar hur viktig rättens och juridikens roll är för planeringen och styrning av landskap och miljö, och de fall som studerats och analyserats är den svenska utbyggnaden av 3G-infrastruktur och vindkraften. Utifrån ett rättssociologiskt planeringsperspektiv visar Stefan Larsson (som också disputerat i rättssociologi tidiThis PhD thesis in Spatial Planning argues for the importance of understanding the approaches to knowledge and rationalities embedded in spatially relevant decision-making. It emphasises the significance of seeing law as an empirical object of study for planning and environmental management. The Swedish development of wind power and 3G mobile infrastructures are used as cases to study these issues
The urinary bladder is responsible for storage and expulsion of urine. Proper urination depends on an ability of the bladder to adjust to increasing volume and to contract during micturition. A disturbance of bladder contractility may affect continence. In the present thesis I have used genetic, biochemical and physiological approaches to examine the role of caveolae and mircoRNAs in bladder funct
Photosynthesis is performed by a multitude of organisms, but in P nearly all cases, it is variations on a common theme: absorption of light followed by energy transfer to a reaction center where charge separation takes place, This initial form of chemical energy is stabilized by the biosynthesis of carbohydrates. To produce these energy-rich products, a substrate is needed that feeds in reductive
Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted
Groundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective counterme
Background: Carry Life UF is a novel peritoneal dialysis (PD) technology for improved fluid management using steady concentration PD (SCPD). The Carry Life UF treatment starts with a manual peritoneal fill of 1.36% glucose PD fluid, followed by a 5-hour treatment where small amounts of glucose are continuously added to maintain a stable intraperitoneal glucose concentration. A recent in-center cli
Bakgrund: Den kurativa behandlingen för resektabla lokalt avancerade stadier av cancer i munhålan innefattar i regel en kombination av kirurgi och radioterapi (RT). Huruvida RT bör ges först och därefter följas av kirurgi, eller om tumören bör opereras bort först, följt av RT postoperativt, har dock inte studerats i någon större omfattning.Syfte: Denna avhandling undersöker olika aspekter av pre- Background: The curatively intended treatment for resectable locally advanced stages of oral cavity cancer (OCC) generally involves a combination of surgery and radiotherapy (RT). However, whether to apply RT first and then proceed with surgery, or to resect the cancer and subsequently administer RT, has not been extensively studied. Aims: This thesis examines various aspects of pre- versus postop
Fine-grained windblown deposits, known as loess, in which fossil soils (palaeosols) are preserved, serve as excellent records of past climate. However, paleoclimate reconstruction studies on loess-palaeosol sequences (LPS) in Southeastern Europe have primarily focused on climate changes during the last one or two glacial-interglacial cycles. Surprisingly, little attention has been given to the cli
In 1997 Tetra Brik Packaging Systems (TBPS) introduced the Prisma family into the portfolio. The family, which contains four volumes: X ml, 330 ml, 1000 ml and 2000 ml, is characterised by having eight panels at mid height. The new shape of the packages has forced TBPS to make modifications in the equipment and alterations in the distribution chain, from producers to consumers. This master's
Regular midwinter counts of waterfowl (included in theInternational Midwinter Counts, IWC, organized by whatis now Wetlands International) has been undertaken inSweden since the start in 1967 and are still going on,now as a part of the National Environmental MonitoringProgramme. After the first exploratory years includingcountry-wide surveys in 1971–1973 undertaken bothfrom the ground, the air and
Regular midwinter counts of waterfowl (included in theInternational Midwinter Counts, IWC, organized by whatis now Wetlands International) has been undertaken inSweden since the start in 1967 and are still going on,now as a part of the National Environmental MonitoringProgramme. After the first exploratory years includingcountry-wide surveys in 1971–1973 undertaken bothfrom the ground, the air and
Release properties of intrahippocampal transplants of noradrenergic neurons were monitored by microdialysis in awake and halothane-anaesthetized rats. Fetal locus coeruleus neurons were implanted as a cell suspension into hippocampi deprived of their innate noradrenalin (NA) innervation by intraventricular 6-hydroxydopamine treatment. Dialysis probes of the loop type were implanted into the dorsal
Parkinson's disease is associated with multiple cognitive impairments and increased risk of dementia, but the extent of these deficits varies widely among patients. The ICICLE-PD study was established to define the characteristics and prevalence of cognitive change soon after diagnosis, in a representative cohort of patients, using a multimodal approach. Specifically, we tested the 'Dual Syndrome'
Elevated molybdenum (Mo) contents in organic-rich sediments are indicative of deposition from an anoxic and sulfide-rich (euxinic) water-column. This can be used for tracing past euxinic conditions in ancient oceans from sedimentary archives. Conventional analytical detection of elevated molybdenum levels is, however, expensive and cannot be directly performed in the field. Here, we show that hand
Background: Squamous cell cancer of the anus (SCCA) is a rare malignancy, but the incidence is increasing. It isassociated with humman papilloma virus infection. The standard treatment is radiotherapy (RT) combined withchemotherapy, usually 5-fluorouracil (5FU)/Mitomycin C (MMC). This treatment is relatively effective, butrecurrence still represents a problem especially in locally advanced SCCA.Th
The GHG-CCI project is one of several projects of the European Space Agency's (ESA) Climate Change Initiative (CCI). The goal of the CCI is to generate and deliver data sets of various satellite-derived Essential Climate Variables (ECVs) in line with GCOS (Global Climate Observing System) requirements. The "ECV Greenhouse Gases" (ECV GHG) is the global distribution of important climate relevant ga
