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Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase

The evolution of multiple active site configurations in a designed enzyme

Developments in computational chemistry, bioinformatics, and laboratory evolution have facilitated the de novo design and catalytic optimization of enzymes. Besides creating useful catalysts, the generation and iterative improvement of designed enzymes can provide valuable insight into the interplay between the many phenomena that have been suggested to contribute to catalysis. In this work, we fo

Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes : The Case of Serum Paraoxonase 1

An Enzyme with High Catalytic Proficiency Utilizes Distal Site Substrate Binding Energy to Stabilize the Closed State but at the Expense of Substrate Inhibition

Differential effects of tree species identity on rhizospheric bacterial and fungal community richness and composition across multiple trace element-contaminated sites

Accurate prediction of substitution rates at protein sites with a mutation-selection model

Majorana sweet spots in three-site Kitaev chains

Minimal Kitaev chains, composed of two quantum dots connected via a superconductor, have emerged as an attractive platform to realize Majorana bound states (MBSs). These excitations exist when the ground state is degenerate. The additional requirement of isolating the MBS wave functions further restricts the parameter space to discrete sweet spots. While scaling up to Kitaev chains with more than

Site-dependent nuclear dynamics in core-excited butadiene

Making and Contesting Far Right Sites of Memory : A Case Study on Romania

The role of blogs and news sites in science communication during the COVID-19 pandemic

Sustainable Environmental Clean-up : Dynamic assessment for sustainable remediation of contaminated sites

Optimal Landfill Site Selection for Solid Waste of Three Municipalities Based on Boolean and Fuzzy Methods: A Case Study in Kermanshah Province, Iran

Privacy and Information Sharing on Social Networking Sites

An exploratory study of Middle Stone Age and Later Stone Age site locations in Kenya’s Central Rift Valley using landscape analysis : a GIS approach

The Kenyan central rift has witnessed dramatic climatic changes over relatively short periods of time in response to global climatic changes, with the water levels of the lakes within the rift rising and falling with these changing conditions. There is considerable evidence showing extreme wet and dry phases throughout their existence. These wet and dry phases also influenced the vegetation cover,

Comparison of soldier fly (Diptera: Stratiomyidae) and thick-headed fly (Diptera: Conopidae) diversity at two trapping sites

Jämförelse av två flugfamiljers mångfald i två olika naturtyper Djurs mångfald är inte bara intressant utan även viktigt för att vår värld ska fungera i harmoni och kretsloppen ska slutas och gå runt. Vissa djur behövs för att bryta ned vissna växter och andra för att hålla insekters antal i schack. Några djur kan även vara tecken på om naturen mår bra eller dåligt. Olika naturtyper är hem för olBiodiversity is a big part of the understanding of our life and its surroundings. Only a fraction of the earth’s species are known and many are yet to be found. When describing new species often both molecular and morphological data is needed to fully resolve cryptic taxa. In this study, the diversity of two Diptera families, soldier flies (Stratiomyidae) and thick-headed flies (Conopidae), have b

Regulation of ESR1 expression by promoter methylation and single nucleotide variants in predicted miRNA target sites in the 3' untranslated region

Post-breeding traits and disturbance ecology of Kentish Plovers Charadrius alexandrinus at a moulting site in the German Wadden Sea

Data Augmentation to Increase Multi-Site Robustness for Convolutional Neural Networks - A case study on MRI segmentation of target and organs at risk for prostate cancer

Fort McMurray - the gentrification of the Lower Town Site

Management of saltpans as potential foraging sites for shorebirds

Abstract Estuaries and salt marshes are important wetlands used by waterbirds during winter and migration. However, many salt-marshes have been transformed into salinas, which currently function as high-tide roosts. Since traditional salt production is no longer profitable, many salinas have been abandoned or converted into aquaculture potentially becoming less attractive to waders. In this study