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From a rural idyll to an industrial site: an analysis of hydraulic fracturing energy sprawl in Central Appalachia

This paper analyzes land-system dynamics changes due to energy infrastructure development and explores the environmental and social ramifications of hydraulic fracturing, through a case study in Central Appalachia. Grounded in photographic data, satellite images, and ethnographic material, this study demonstrates landscape and embodied experiences of change over time. Data show major shifts in ter

Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats

Lorcaserin, which is a selective agonist of serotonin2C receptors (5-HT2CRs), is a new FDA-approved anti-obesity drug that has also shown therapeutic promise in other brain disorders, such as addiction and epilepsy. The modulation of dopaminergic function might be critical in the therapeutic effect of lorcaserin, but its exact effect is unknown. Here, we studied the effect of the peripheral admini

Modulating electron density of vacancy site by single Au atom for effective CO2 photoreduction

The surface electron density significantly affects the photocatalytic efficiency, especially the photocatalytic CO2 reduction reaction, which involves multi-electron participation in the conversion process. Herein, we propose a conceptually different mechanism for surface electron density modulation based on the model of Au anchored CdS. We firstly manipulate the direction of electron transfer by

Ontogeny of vesicular monoamine transporter mRNAs VMAT1 and VMAT2 II. Expression in neural crest derivatives and their target sites in the rat

We used in situ hybridization histochemistry to study the expression of the two vesicular monoamine transporters (VMAT1 and VMAT2) during embryonic development in the rat. In the adult rat VMAT2 is present exclusively in neuronal tissues and VMAT1 is present in the adrenal medulla and in certain intestinal endocrine cells. We found that both transporter molecules are more widely expressed during d

In-Motion-App for remote General Movement Assessment : A multi-site observational study

Objectives To determine whether videos taken by parents of their infants' spontaneous movements were in accordance with required standards in the In-Motion-App, and whether the videos could be remotely scored by a trained General Movement Assessment (GMA) observer. Additionally, to assess the feasibility of using home-based video recordings for automated tracking of spontaneous movements, and to e

Exploring non-immersive virtual reality experiences in tourism : Empirical evidence from a world heritage site

With the popularization of the concept of the metaverse, non-immersive virtual reality (VR) has become a focus of tourism destination marketing. Drawing upon telepresence theory, this study identifies the antecedents and consequences of telepresence to help interpret tourist behavior in the context of non-immersive VR experience. Results revealed that mental imagery and vividness positively predic

Oligosaccharide-receptor interaction of the Galα1-4Gal binding adhesin of Streptococcus suis : Combining site architecture and characterization of two variant adhesin specificities

The sugar binding specificities of two groups of Streptococcus suis, a pig pathogen that causes meningitis also in man, were determined. Both the group represented by a recently characterized strain inhibitable by galactose and N-acetylgalactosamine (type PN) and the group inhibitable by galactose (type PO) were found by hemagglutination and solid-phase binding inhibition experiments to recognize

Groundwater augmentation through the site selection of floodwater spreading using a data mining approach (case study : Mashhad Plain, Iran)

It is a well-known fact that sustainable development goals are difficult to achieve without a proper water resources management strategy. This study tries to implement some state-of-the-art statistical and data mining models i.e., weights-of-evidence (WoE), boosted regression trees (BRT), and classification and regression tree (CART) to identify suitable areas for artificial recharge through flood

Cultural adaptations and island ecology : Insights into changing patterns of pottery use in the Susuya, Okhotsk and Satsumon phases of the Kafukai sites, Rebun Island, Japan

Island chains provide access to terrestrial, coastal and offshore marine resources, attracting peoples and cultures and serving as conduits for migrations and long-distance exchange networks. Situated between Hokkaido and Sakhalin, Rebun Island connected the prehistoric cultures of northeast Asia in a major “marine highway”. Rebun was repeatedly settled by distinct cultures who originated in diffe

Pulseq-CEST : Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard

PURPOSE: As the field of CEST grows, various novel preparation periods using different parameters are being introduced. At the same time, large, multisite clinical studies require clearly defined protocols, especially across different vendors. Here, we propose a CEST definition standard using the open Pulseq format for a shareable, simple, and exact definition of CEST protocols.METHODS: We present