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This analysis of DNA-ploidy heterogeneity in advanced gastric carcinomas is consistent with the hypothesis of the emergence of a single aneuploid cell clone as a crucial mechanism in the progression from early gastric carcinoma to advanced gastric cancer. The prognostic value of DNA-ploidy in gastric cancers has been a matter of controversy. Tumour DNA-ploidy heterogeneity, the presence within the
All languages borrow words from other languages. Some languages are more prone to borrowing, while others borrow less, and different domains of the vocabulary are unequally susceptible to borrowing. Languages typically borrow words when a new concept is introduced, but languages may also borrow a new word for an already existing concept. Linguists describe two causalities for borrowing: need, i.e.
Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women)
Introduction: Arthroscopic partial meniscectomy (APM) after degenerative meniscus tears is one of the most frequently performed surgeries in orthopaedics. Although several randomised controlled trials (RCTs) have been published that showed no clear benefit compared with sham treatment or non-surgical treatment, the incidence of APM remains high. The common perception by most orthopaedic surgeons i
Background: ACMG/AMP and AMP/ASCO/CAP have released guidelines for variation interpretation, and ESHG for diagnostic sequencing. These guidelines contain recommendations including the use of computational prediction methods. The guidelines per se and the way they are implemented cause some problems. Methods: Logical reasoning based on domain knowledge. Results: According to the guidelines, several
Background: Allogenic hematopoietic stem cell transplantation (allo-SCT) is the most effective post-remission treatment for adults with high-risk acute lymphoblastic leukemia (ALL). The aim of the study was to analyze results of unmanipulated haploidentical allo-SCT (haplo-SCT) for adults with ALL and to identify prognostic factors. Methods: We performed a retrospective analysis on 208 adults tran
Den tekniska utvecklingen har möjliggjort nya former av sexuella övergrepp mot barn, där fysiskt möte mellan förövare och barn ofta helt uteblir. Detta har lett till olika typer av utmaningar till det straffrättsliga system som länge varit inriktat på fysiska övergrepp. Trots att forskning visar att digitala övergrepp kan orsaka ett psykiskt lidande som är jämförbart med de vid fysiska handlingar,Advancements in technology have enabled new forms of child sexual abuse, where physical contact between the perpetrator and the child is entirely absent. This development challenged a criminal justice system which has historically focused on physical offences. Research shows that children that have been subjected to online sexual abuse often experience psychological harm that is just as severe as
I juni 2023 tillsatte regeringen en utredning, som tog sig namnet Miljötillståndsutredningen, med syfte att revidera och strömlinjeforma miljötillståndsprocessen. I januari 2025 lämnade denna utredning sitt första betänkande, med omfattande ändringsförslag. Detta bland annat avseende ansvarig prövningsmyndighet samt när och hur samråd, alltså de tillfällena då berörda myndigheter och enskilda ges In June of 2023 the Swedish government appointed an inquiry, which took the name Miljötillståndsutredningen, with the purpose of revising and streamlining the Swedish environmental permitting process. In January of 2025 the inquiry presented its first report, which proposed comprehensive changes. This in part regarding the competent authority for the permitting process as well as when and how part
I Sverige idag finns det ett ökande antal barn som begår brott i kriminella nätverk. Den organiserade brottsligheten i stort pekas av flera aktörer ut som samhällsfarlig, särskilt av den sittande regeringen. Som del av den nationella strategin att slå tillbaka mot den organiserade brottsligheten gav regeringen en särskild utredare i uppdrag att utreda ett antal stora ändringar på straffrättens omrThere is a growing number of children committing crimes in connection with organized crime in Sweden today. Organized crime is widely identified, especially by the current government, as a danger to society. As part of the national strategy to combat this issue, the government appointed a committee to examine and present proposals for several major reforms in criminal law. In May 2025, the committ
This thesis presents a complete digital back-end implementation of a PN-dither least-mean-squares (LMS) background calibration scheme for a 12-bit, 500 MS/s pipeline analog-to-digital converter (ADC). The target converter, designed by a parallel analog project, comprises four 3-bit stages and a 4-bit final flash stage; its actual inter-stage gains depart substantially from their nominal values, re
OBJECTIVES: It has been commonly accepted that untreated acute type A aortic dissection (ATAAD) results in an hourly mortality rate of 1–2% during the 1st 24 h after symptom onset. The data to support this statement rely solely on patients who have been denied surgical treatment after reaching surgical centres. The objective was to perform a total review of non-surgically treated (NST) ATAAD and p
Background and purpose — Different marker-selection methods are applied to represent implant and tibial seg-ments in radiostereometric analysis (RSA) studies of total knee arthroplasty (TKA). Either a consistent set of markers throughout subsequent RSA examinations (“consistent-marker method”) is used or all available markers at each follow-up (“all-marker method”). The aim of this secondary analy
Objectives Comprehensive cost-effectiveness analyses of introducing varicella and/or herpes zoster vaccination in the Swedish national vaccination programme. Design Cost-effectiveness analyses based on epidemiological results from a specifically developed transmission model. Setting National vaccination programme in Sweden, over an 85- or 20-year time horizon depending on the vaccination strategy.
Introduction: The recent Covid-19 pandemic has renewed interest in studying the impact of environmental factors on the airborne transmission of viral infectious diseases. Human rhinovirus is the main cause of acute respiratory infections, primarily driven by young children who have an average of 6 -10 infections annually, while healthy adults typically experience 2–3 infections per year. Although
Premise: Flower color, a key trait influencing plant–pollinator interactions, may be influenced by abiotic factors such as soil. We investigated association between pollinators, soil characteristics, and flower color variations in Digitalis purpurea across native populations in Sweden and introduced populations in Bolivia. Methods: We measured floral traits, reflectance of petals and nectar-guide
Purpose: Brain tumours constitute 25% of childhood neoplasms, and half of them are in the posterior fossa. Surgery is a fundamental component of therapy, because gross total resection is associated with a higher progression-free survival. Patients with residual tumour, progression of residual tumour or disease recurrence commonly require secondary surgery. We prospectively investigated the risk of
Objective: Previous work suggested that the ultrasound-based benign Simple Descriptors can reliably exclude malignancy in a large proportion of women presenting with an adnexal mass. We aim to validate a modified version of the Benign Simple Descriptors (BD), and we introduce a two-step strategy to estimate the risk of malignancy: if the BDs do not apply, the ADNEX model is used to estimate the ri
BackgroundEducation is expected to bring about positive behavioral changes which could lead to improved health behaviors. Parental education is a primary determinant of child health and development. However, some evidence showed inverse associations between high parental education and recommended infant and young child feeding (IYCF) in Bangladesh. How the association of parental education differs
