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The incorporation of drugs into Gelucires has been reported to increase the dissolution rate of poorly soluble drugs, often leading to improved drug bioavailability. In pharmaceutical applications, it is important to know how the excipient interacts with the drug, and how the mixture behaves during manufacturing, storage as well as during administration. The uptake of water by an amphiphilic excip
The administration of hydroxocobalamin (OHCob), alone or with sodium thiosulfate, is a standard therapy for cyanide poisoning. OHCob is a red chromophore, and its interference with co-oximetric and colorimetric laboratory measurements has been evaluated in a few conflicting reports. The interference of OHCob was investigated in samples spiked with 10 different concentrations of OHCob (0-1500 mg/L)
Popular Abstract in Swedish Arkitekter har kritiserats för att ha en vag föreställning om begreppet kropp och hur det förhåller sig till den arkitektur de gestaltar. Om kropp alls medvetandegörs är det på ett allmänt och självidentifierande plan, alternativt genom de standardiserad mått som olika byggnormer föreskriver. Arkitekturens kroppsliga relationer och kroppens sensoriska meningsskapande ärBeginning with the notion that spatial and material qualities of architecture set limits and create conditions for how we make use of it, the overall aim and ambition of this thesis is to develop this notion and to contribute to a deeper understanding of the relationships that are produced between the materiality of architecture and a bodily appropriation of it. To investigate this the thesis esta
Popular Abstract in Swedish Intensifieringen av jordbruket sedan 1950-talet har lett till en ökad matproduktion men också orsakat miljöproblem så som förlust av biologisk mångfald, jorderosion, övergödning, ökade utsläpp av växthusgaser samt föroreningar av bekämpningsmedel. Det är därför nödvändigt att utveckla ett mer hållbart jordbruk samtidigt som vi upprätthåller den globala matförsörjningen Agricultural intensification has raised the global food production but also caused major concerns about environmental and health effects, including contamination by pesticides. Pesticide applications may induce toxicity not only on the target pest species but especially on non-target species. Hence we need to replace pesticides with management that promote organisms that suppress pest population.
In agriculture, as in industry, have many physically demanding jobs disappeared and the physical stress factors have changed. However, the working days in farms are often long, and it is difficult to hire workers for help as the work conditions are considered to be harsh. The thermal work environment in farms is one of the factors influencing the work conditions. This study aimed to find out the p
Biogas is a renewable source of energy. Residues from agriculture contain considerable energy potential and are suitable substrates for biogas production, but in Sweden the utilization of these residues is low. The economic feasibility of biogas production in general is low, and only limited subsidies are provided by the state. In the present work, the feasibility of low-temperature digestion of c
A robot has to visit all nodes and traverse all edges of an unknown undirected connected graph, using as few edge traversals as possible. The quality of an exploration algorithm A is measured by comparing its cost (number of edge traversals) to that of the optimal algorithm having full knowledge of the graph. The ratio between these costs, maximized over all starting nodes in the graph and over al
Popular Abstract in Swedish SAMMANFATTNING PÅ SVENSKA (Swedish summary) Ultraljud används sedan 1970-talet rutinmässigt under graviditet. Undersökningen görs vanligen vid 17-18 graviditetsveckor och syftet med undersökningen är att datera graviditeten dvs bestämma tiden för beräknad förlossning. Man upptäcker också eventuella tvillingar vid denna undersökning. Redan tidigt visade det sig att visWe studied the prenatal detection rate of various malformations during a study period of 16 years in a population in southern Sweden consisting of 141 240 deliveries. The overall detection rate was 28.4% and the false positive diagnoses were very few. We studied the effect of prenatal diagnosis on the rate of spina bifida in southern Sweden compared with the rest of the country and could show tha
1. The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact pancreatic islets. Immunostaining in combination with confocal microscopy revealed that the superficial cells consisted of 35 % insulin-secreting B-cells and 65 % non-B-cells (A- and D-cells). 2. Two types of cell, with distinct electrophysiological properties, could be function
This study was conducted at three oncology outpatient clinics in Iceland. The overall aim was to investigate outpatient psychosocial distress, coping strategies and satisfaction with care and to explore patients? experiences of having cancer while receiving treatment. Specific focus was on comparison between genders, age groups and those who lived close to treatment centre vs. those who had to
Background: The acid-producing part of the rat stomach (fundus) is rich in endocrine cells, i.e. ECL cells and A-like cells. The ECL cells operate under gastrin control and manufacture histamine, the chromogranin-derived peptide pancreastatin and an unidentified peptide hormone. The A-like cells produce ghrelin, a newly discovered growth hormone-releasing hormone. Surgical removal of the entire gl
In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns t
Popular Abstract in Swedish Denna avhandling utgör den första delen i en planerad serie på tre rapporter med utgångspunkt i data insamlade läsåret 1993/94 i årskurs 9 vid en grundskola, där det lokala skolprojektet Tonåringens livssituation och livstolkning genomförts i ämnet religionskunskap. Det övergripande syftet med studien är att undersöka vilka centrala livsvärden eleverna ger uttryck för iThis dissertation makes up the first report based on data collected during the project "Teenagers: aspects of their life style and attitudes" (Tonåringens livssituation och livstolkning) in the subject Religious Studies taken by pupils attending Year 9 during the 1993/94 school year. The general aim of the study is to discover the central values of life which pupils hold, as expressed in an essay
Car developers use digital human modeling tools to analyze and visualize car interiors in relation to human characteristics before the vehicles are actually constructed. Developers, reviewers and users of human simulation tools often claim that such tools can reduce development time and costs. In car industry companies today, human simulation tools are used by a single or a few experts in an infor
The morphologies and proton-transport efficiencies of segmented copoly(arylene ether sulfone) ionomers that contain tetrasulfonated sequences are compared with the corresponding copolymers with disulfonated sequences. Tetrasulfonated 4,4′-bis[(4-chlorophenyl)sulfonyl]-1,1′-biphenyl (sBCPSBP) is synthesized by metalation and sulfination. This new monomer is then used in K2CO3-mediated polycondensat
Background and Purpose: Leptin, an important hormone for body weight regulation, may be involved in the pathogenesis of cardiovascular manifestations of obesity. We tested whether leptin may be an independent risk marker for stroke in a case-referent study. Methods: Definitive acute stroke events, defined by MONICA criteria, were identified from October 1, 1995 to April 30, 1999. Referents without
Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 el
Vernakalant is a novel, relatively atrial-selective antiarrhythmic agent for conversion of atrial fibrillation (AF) to sinus rhythm. This study examined the safety and efficacy of vernakalant in converting atrial flutter (AFL) to sinus rhythm. This was a phase 2/3, randomized, double-blind, placebo-controlled trial. Adults with AFL received either a 10 min infusion of 3.0 mg/kg vernakalant (n 39)
The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development
BACKGROUND: Internal hernias occur frequently after laparoscopic gastric bypass. We have found no data on the relative strength of the various techniques available for closing these defects. The present study was performed to obtain such data to form a theoretical basis for clinical studies. METHODS: Six piglets were operated laparoscopically and four loops of small bowel created in each. These me
