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The composition of the colonic microflora is essential for the health of the human host. To be able to survive, the microflora is dependent of a continuous supply of substrate. In this respect dietary fibre and other indigestible carbohydrates, of which the consumption in affluent societies is generally low, are of great importance. Numerous of studies have demonstrated beneficial effects of dieta
Background: Animal studies suggest that the arginine vasopressin (AVP) system plays a role in glucose and fat metabolism, but data from humans are limited. Method and results: We analysed plasma copeptin (copeptin), a stable C-terminal fragment of the AVP pro-hormone in the large, Swedish, population-based cohort Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC, n=6103). Using baseline
Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. Large and diverse data on PID genes and proteins can enable systems biology studies on their
Ongoing consumption of fossil-based fuels generates a massive amount of greenhouse gases. This may lead to global warming that is currently threatening human society and wild animal habitats. Hydrogen is an energy carrier with the highest energy content per weight compared to other all fuels and no carbon dioxide is released when combusted. Thermophilic bacteria belonging to the genus of Caldicell
In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati
Background: No liquid biomarkers are approved in renal cell carcinoma (RCC), making early detection of recurrence in surgically treated nonmetastatic (M0) patients dependent on radiological imaging. Urine- and plasma free glycosaminoglycan profiles—or free GAGomes—are promising biomarkers reflective of RCC metabolism. Objective: To explore whether free GAGomes could detect M0 RCC recurrence noninv
The aviation industry is a contributor to the global greenhouse gas emissions. Moving away from fossil-based fuels has proven to be more difficult than expected. One possibility for the aviation industry is the development of sustainable aviation fuels (SAFs), produced from renewable sources such as biomass and waste. Certain problems have been discovered with using SAFs, however. The fuels are us
Abstract Parkinson’s disease (PD) is characterized by selective loss of dopaminergic neurons and progressive accumulation of intracellular alpha synuclein protein aggregates known as Lewy bodies. Due to pathological links to both sporadic and inherited cases of PD, alpha synuclein (asyn) has become a focal point for study, although the exact mechanisms of its toxicity are not known. In contrast to
Enzyme engineering for a better future It is essential for many organisms on this planet to be able to digest plants. One of those organisms is the blue mussel, which uses certain enzymes in its stomach to break down sugar fibers in the algae that it eats. But how does this really work, and can we use it for anything? Plant cells have very strong walls, protecting them from environmental stress.
Background: FTV Capital is a private equity company specializing in growth equity. Even though the company has been very successful, the private equity industry is highly competitive and more and more companies are turning their strategy towards growth equity. To stand out and keep the competitive advantage, having a strong brand and communicating efficiently is particularly important for a privat
I Sverige drabbas omkring 300 barn av cancer varje år och majoriteten av dem är bara fyra-fem år gamla när de får sin diagnos. Omkring två tredjedelar av barncancerdiagnoserna utgörs av leukemier, lymfom och hjärntumörer, medan den sista tredjedelen är olika solida tumörformer som njurtumörer och nervvävnadstumörer i buken. Cancersjukvårdens utveckling under de senaste årtiondena har medfört en avPurpose: The purpose of this study was to evaluate the impact of including PET (Positron Emission Tomography) in the process of pediatric radiation therapy planning. The aim was to study the effect on target volumes and how this in turn affects the resulting treatment plans. This study also aims to compare the estimated risks of various long-term complications and how the use of PET influences the
During the spring semester 2018, an investigation about supplementary cleaning of the waste water at Dow Chemical site in Landskrona was done. Different water-based binders from acrylic monomers are produced by Dow and large amounts of water is used for such processes. The wastewater, that is treated currently by ultrafiltration (UF), contains different chemical residues such as surfactants, resid
In the Tanzanian district of Karagwe the NGO KADERES is working with agricultural development. In relation to this they produce fair trade coffee obtained from local farmers. Coffee husks are created as a waste product from the plant and are currently not used for any purpose. Instead they are left outside the factory. The propose of this project is to find a way to create briquettes from these hu
Popular Abstract in Swedish Bland infektionssjukdomarna är Enterobacteriaceae den viktigaste gruppen av bakterier. Den kan orsaka ett flertal olika infektioner så som blodförgiftning, urinvägsinfektion, hjärnhinneinflammation, bukhinneinflammation, gallvägsinfektioner, lunginflammation och diarrésjukdomar. Den vanligaste orsaken till blodförgiftning är bakterier som har kommit in i blodet från uriIn human medicine, the most important family of bacteria is Enterobacteriaceae, which includes genera and species that cause well-defined diseases and also nosocomial infections. These bacteria can give rise to numerous infections such as septicaemia and urinary tract infections. It is important to combat these infections with effective antibiotics, because many of them are associated with high mo
Brine disposal remains one of the most significant environmental challenges associated with desalination, driving the need for sustainable technologies such zero liquid discharge (ZLD) systems. Among emerging ZLD techniques, membrane distillation crystallization (MDCr) offers a promising approach by integrating water recovery with salt crystallization. In MDCr, a hydrophobic membrane separates wat
Background and Aim: Artificial intelligence (AI) in mammography screening can aid cancer detection. Commercially available AI systems can assign region and exam scores based on malignancy suspicion. Despite promising suggestions, clinical implementation is limited- partly due to a lack of trust among radiologist and prospective evaluation. Inevitably, this leads to the question of how an AI system
Against the backdrop of the accelerated advancement of a new round of technological revolution and industrial transformation, the global economy is moving towards a development model driven by innovation as its core. Enterprises, as important carriers of technological progress and institutional innovation, are facing increasingly fierce market competition and transformational pressures. In this pr
Reducing eutrophication in our surface waters caused by nutrient overload is of importance in order to ensure an environment in ecological balance for future generations. Municipal wastewater treatment plants are the main point source of nutrients emissions. Effluent water can be treated by introducing a final advanced treatment step to existing wastewater treatment plants. The present thesis conc
Objective Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are globally prevalent chronic diseases that affect millions of individuals in ageing populations. Hip and knee replacements are well established and effective treatments in patients suffering from end-stage OA. Understanding how T2DM influences the outcomes of these surgeries is important for optimising patient care and improving s
