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Background The alpha-emitter radium-223 (Ra-223) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. We aimed to study mature outcomes from a randomised, multicentre, phase II study of Ra-223. Methods Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to fou
Popular Abstract in Undetermined Denne afhandling præsenterer en ny udlæsnings metode udviklet til cantileverbaserede sensorer. Cantilevere er tynde vipper, der er fastgjorte i den ene ende, og som igennem de seneste ti °ar har vist sig at være en interessant ny type bio/kemisk sensor. Den specifikke genkendelse af et kemikalie viser sig ved at cantileveren bøjer som følge af det skabte overfladesThis thesis presents a novel read-out method developed for cantilever-based sensors. Cantilevers are thin beams clamped at one end and during the last 10 years they have emerged as an interesting new type of bio/chemical sensor. The specific recognition of a chemical manifests itself as a bending of the cantilever from the generated surface stress. Conventionally the read-out used for this type of
Background Cancer is associated with an increased risk of thromboembolic diseases, but data on the association between prostate cancer and thromboembolic diseases are scarce. We investigated the risk of thromboembolic disease in men with prostate cancer who were receiving endocrine treatment, curative treatment, or surveillance. Methods We analysed data from PCBaSe Sweden, a database based on the
FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from
Background: Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The effect of disulfiram was evaluated according to the primary outcome of an intake of alcohol below 30 and 20 g/d for men and women, respectively, as we
The mineral dust cycle responds to climate variations and plays an important role in the climate system by affecting the radiative balance of the atmosphere and modifying biogeochemistry. Polar ice cores provide unique information about deposition of aeolian dust particles transported over long distances. These cores are a palaeoclimate proxy archive of climate variability thousands of years ago.
We have previously described the efficient guidance and unidirectional sliding of actin filaments along nanosized tracks with adsorbed heavy meromyosin (HMM; myosin II motor fragment). In those experiments, the tracks were functionalized with trimethylchlorosilane (TMCS) by chemical vapor deposition (CVD) and surrounded by hydrophilic areas. Here we first show, using in vitro motility assays on no
BACKGROUND AND PURPOSE: To determine how a recently proposed clinical stroke subclassification corresponds to specific findings on computed tomography (CT) and magnetic resonance imaging (MRI) of the brain. METHODS: Two hundred twenty-eight patients with first-ever stroke were divided into four clinical subgroups: (1) total anterior circulation syndrome: both cortical and subcortical symptoms from
Purpose: This bachelor thesis examines the impact of organisational culture on the adherence to Information Security (hereinafter IS) protocols (IS compliance) and the crucial factors leading to varying levels of consistency in information security awareness (hereinafter ISA) between organisational departments while considering the unique Swedish cultural qualities. Methodology: This thesis reach
Bearing a child and giving birth are often considered as a life-changing event in the life of a woman and her family, a source of joy and fulfillment. But in spite of the progress achieved in the last century, every two minutes one woman still dies from pregnancy or childbirth related causes (WHO 2018). All too often, becoming a mother can be associated with pain, suffering and even distress, disa
A detailed flammability evaluation of different materials used in the nuclear power industry is presented as an example of how important are physical observation and detailed analysis in the interpretation of test data. The objective is to provide different criteria that could allow the use of standard test data in fire modeling. So far most fire test data has only been used as an element for rank
Self-compassion has not yet been studied in younger children. The aim of this study was to explore self-compassion in children between 10-13 years of age and examine how self-compassion is related to well-being and social perspective-taking. In addition we wanted to explore possible age or sex differences in self-compassion. The participants consisted of 228 children from two elementary schools in
The potential of information technology as a means to invigorate democratic practise is constantly under discussion. Regardless of the differing opinions as to the most suitable way to utilise IT, there are certain democratic core values that have to be considered. One of these is freedom of information, defined by us as the right of every citizen to seek, obtain and express information. The aim o
Thermal comfort has direction implications for energy efficiency and sustainable development. From a global perspective, about 40% of total primary energy is used in buildings, contributing to more than 30% of CO2 emissions [1]. The fact that the common practices of clothing choices have impact on energy efficiency is ignored [2-3]. This paper analyzed and proposed clothing insulation required for
The objective of this study is to describe a completely new 10-day gross primary production (GPP) product (MGPP LSA-411) based on data from the geostationary SEVIRI/MSG satellite within the LSA SAF (Land Surface Analysis SAF) as part of the SAF (Satellite Application Facility) network of EUMETSAT. The methodology relies on the Monteith approach. It considers that GPP is proportional to the absorbeThe objective of this study is to describe a completely new 10-day gross primary production (GPP) product(MGPP LSA-411) based on data from the geostationary SEVIRI/MSG satellite within the LSA SAF (Land SurfaceAnalysis SAF) as part of the SAF (Satellite Application Facility) network of EUMETSAT.The methodology relies on the Monteith approach. It considers that GPP is proportional to the absorbedph
Background: Diabetes mellitus (DM) is an established risk factor for intermittent claudication (IC) and other manifestations of atherosclerotic peripheral arterial disease. Indications for surgery in infrainguinal IC are debated, and there are conflicting reports regarding its outcomes in patients with DM. Aims of this study were to compare both short- and long-term effects on total- and cardiovas
BACKGROUND: Viral infections of the upper airways are the most common cause for absence from work or school, and there is evidence for probiotic efficacy in reducing the incidence and severity of these infections.OBJECTIVES: We aimed to confirm the previously reported beneficial effects of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 against community-acquired common
Objectives Nocturnal hypoxia in obstructive sleep apnoea (OSA) is a potential risk factor for cancer. We aimed to investigate the association between OSA measures and cancer prevalence in a large national patient cohort. Design Cross-sectional study. Settings 44 sleep centres in Sweden. Participants 62 811 patients from the Swedish registry for positive airway pressure (PAP) treatment in OSA, link
Background The shortage of surgeons, anaesthesiologists and obstetricians in low-income and middle-income countries (LMICs) is occasionally bridged by foreign surgical teams from high-income countries on short-term visits. To advise on ethical guidelines for such activities, the aim of this study was to present LMIC stakeholders' perceptions of visiting surgical teams from high-income countries. M
