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Modeling and Prediction in Diabetes Physiology

Diabetes is a group of metabolic diseases characterized by the inability of the organism to autonomously regulate the blood glucose levels. It requires continuing medical care to prevent acute complications and to reduce the risk of long-term complications. Inadequate glucose control is associated with damage, dysfunction and failure of various organs. The management of the disease is non trivial

Microcontact imprinting based surface plasmon resonance (SPR) biosensor for real-time and ultrasensitive detection of prostate specific antigen (PSA) from clinical samples

Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via

Environmental life cycle assessment of diets with improved omega-3 fatty acid profiles

A high incidence of cardiovascular disease is observed worldwide, and dietary habits are one of the risk factors for these diseases. Omega-3 polyunsaturated fatty acids in the diet help to prevent cardiovascular disease. We used life cycle assessment to analyse the potential of two strategies to improve the nutritional and environmental characteristics of French diets: 1) modifying diets by changi

Fractures among patients with dizziness : A ten-year follow-up

Background: The number of elderly people persons suffering from dizziness is substantial, and dizziness is a risk factor for falls and fractures. Fall-related fractures represent a major public health issue. Longitudinal studies can help find ways of predicting fall-related fractures among frail elderly persons with multisensory dizziness. The aim of the present study was therefore to investigate

Short Range Gesture Sensing and Classification Using Pulsed Millimeter-Wave Radar and Convolutional Neural Networks

Human hand gestures present a novel way of interacting with electronic devices. A millimeter-wave radar setup utilizing a pulsed Resonant-Tunneling Diode signal generator in the 60 GHz ISM band is used to measure 12 different hand gestures. The data is used to train and validate Convolutional Neural Networks (CNNs). The measurement setup utilizes a real time sampling oscilloscope and down-mixing o

Disability in Ghana. A Foucauldian discourse analysis examining values and the construction of the subject in legal documents

Across the globe, persons with disabilities do not enjoy equitable access to social, economic, and human capital compared to their non-disabled counterparts, and are politically, economically and culturally disenfranchised. Ghana ratified the Convention on the Rights of Persons with Disabilities (CRPD) in 2012 and is thereby obliged to amend their national disability laws, making them compatible w

Motion Planning using Positively Invariant Sets on a Small-Scale Autonomous Vehicle

Self-driving technology has the opportunity to increase safety in automotive transportation by reducing the impact of human error. Motion planning is a key component of an autonomous system, responsible for providing reference trajectories and paths that the vehicle should follow. This thesis studies a motion-planning algorithm based on positively invariant sets. The focus is on design, implementa

Fredsbevarande kvinnor : en analys av hur kvinnor som tjänstgör i fredsbevarande operationer framställs i artiklar från FN:s nyhetscenter

Kvinnor utgör en relativt ny komponent inom FN:s fredsbevarande operationer och ökar stadigt i antal. Därför är det viktigt att utvärdera hur kvinnor porträtteras i mediediskursen, eftersom media kan bidra till att reproducera könsstereotyper eller sträva mot social förändring. Syftet med denna uppsats är att undersöka vilken bild som förmedlas genom FN:s nyhetscenter av kvinnor som tjänstgör i FNWomen are a relatively new component in the UN peacekeeping operations and are steadily increasing in number. Hence it is essential to evaluate how women are being portrayed in media discourse, since media has a vital role in the reproduction of gender stereotypes, or has the possibility to strive towards social change. The purpose of this paper is to examine how women, serving in UN peacekeeping

The Market Freedoms as a Specific Form of Human Rights

The market freedoms of the EC Treaty first of all commit the Member States not to erect hindrances to the internal market. Obstacles to the free movement of goods and the other market freedoms may also originate from other authors than the Member States. Individuals may hamper the functioning of the internal market, and even the European Community itself might pass legislation affecting the market

Naturens politik och politikens natur: Tropisk skog och REDD i förhandling

In the pursuit to abate climate change, multilateral approaches have been the prevailing weapon of choice. The goal of these approaches has been to reduce emissions of CO2 and other greenhouse gases to avoid dangerous anthropogenic climate change. Recent assessments of emission sectors show that 20% of emissions are caused by deforestation and degradation of tropical forests. Hence, a new forest r

Familial risk of ischemic and hemorrhagic stroke : a large-scale study of the Swedish population

BACKGROUND AND PURPOSE: Previous studies of familial risks have often combined ischemic and hemorrhagic stroke even though it seems unlikely that these 2 very different pathological conditions are under the same genetic influence. This study is the first to investigate the concordant (same subtype) and disconcordant (different subtype) association between ischemic and hemorrhagic stroke.METHODS: D

ICU-recovery in Scandinavia : a comparative study of intensive care follow-up in Denmark, Norway and Sweden

OBJECTIVES: The aim of our study was to describe and compare models of intensive care follow-up in Denmark, Norway and Sweden to help inform clinicians regarding the establishment and continuation of ICU aftercare programmes.METHODS: Our study had a multi-centre comparative qualitative design with triangulation of sources, methods and investigators. We combined prospective data from semi-structure

Engineered nanomaterials in in vivo and in vitro models

Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. Additionally, the NW high aspect ratio geometry is of gr

Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data

Amyloid fibril formation is a hallmark of neurodegenerative disease caused by protein aggregation. Oligomeric protein states that arise during the process of fibril formation often coexist with mature fibrils and are known to cause cell death in disease model systems. Progress in this field depends critically on development of analytical methods that can provide information about the mechanisms an

Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

In Parkinson's disease, the degeneration of dopaminergic neurons in substantia nigra leads to a decrease in the physiological levels of dopamine in striatum. The existing dopaminergic therapies effectively alleviate the symptoms, albeit they do not revert the disease progression and result in significant adverse effects. Transplanting dopaminergic neurons derived from stem cells could restore dopa

Pancreatic Growth and Secretion. An Experimental Study on Growth Factors in Rat and Mouse

Popular Abstract in Swedish Bukspottkörteln, pancreas, är ett viktigt organ för ämnesomsättningen. Dess viktigaste funktioner är att tillverka enzymer och bikarbonat som utsöndras till tolvfingertarmen, duodenum samt hormoner som utsöndras till blodbanan. De viktigaste enzymerna är amylas som bryter ned olika sockerarter och stärkelse, lipas som bryter ned fett och trypsin som bryter ned proteinerThe pancreas is a central organ in the digestion of food as well as in glucose metabolism. Its two major functions are exocrine and endocrine secretion. These are meticulously regulated processes that depend on hormonal response to gastrointestinal contents and blood glucose levels through feedback mechanisms, but also to the status of pancreas in health and diseases. The present thesis aimed at f

Construction and Environment - Improving energy efficiency

The construction sector provides the direct means to the development and expansion of economic activities, but is at the same time a major consumer of physical and natural resources and a polluter of the environment. Over the last decades, the environmental impact of construction activities has grown dramatically due to the increase in the world population and greater industrial and human activity

Victims of Conservation or Rights as Forest Dwellers: The Van Gujjar pastoralists between contesting codes of law

The Van (forest) Gujjars, surviving as forest pastoralists in the central part of the Indian Himalaya, are a people who, due to their nomadic lifestyle, have since colonial rule found themselves at the margin of Indian society. This paper will look at the relationship between the Van Gujjars and their forest base in a historical perspective from colonial rule to 'conservation of nature' and the 'r

The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses