Search results

Vid kronisk myeloisk leukemi har målstyrd, kontinuerlig behandling med tyrosinkinashämmare lett till dramatiskt förbättrad överlevnad. Efter ett flertal år uppnås djupt molekylärt svar hos ca 50 procent av patienterna; ca 50 procent av dem kan då avbryta behandlingen utan tecken på återfall. Kontinuerlig behandling med tyrosinkinashämmare kan ge långsiktiga biverkningar. Efter patentutgång för imaChronic myeloid leukemia - a model disease for targeted therapy Chronic myeloid leukemia (CML) pioneered as the first human malignancy linked to a specific cytogenetic aberration (the Philadelphia chromosome), which led the way to specific targeted therapies with imatinib (Glivec) and later tyrosine kinase inhibitors (TKI). Continuous TKI administration, blocking the oncogenic fusion protein Bcr-A

Parkinson: On course against Cure. Our research group focuses on Parkinson's disease (PD), the second most common neurodegenerative disease, with approximately 20 000 patients in Sweden and 2.3 million in Europe.

Building new wind farms is an important part in the transition to renewable energy. However these projects often require large investments, and the cost of upgrading the existing infrastructure - to allow for the connection of new parks - is a component that cannot be ignored. When several wind farms seek interconnections, they are forced to collaborate and financing the connection. This leads to

Diabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. Despite insulin injection treatment, diabetic patients suffer from long-term complications, such as blindness and kidney failure. Therefore, a central goal of diabetes research is to regenerate beta cells or produce large numbers of functional beta cells for transplantation. The successful generation of beta

Abstract in Undetermined Este trabajo presenta el desarrollo de un banco de pruebas experimental para el análisis de la respuesta mecánica de los asientos de vehículos durante la entrada y salida de pasajeros. Para realizar este desarrollo, se consideran dos fases: la primera fase es la captura de datos, realizada mediante una manta sensorizada con una red de galgas de presión y un sistema de foto

For how many years was a farmer responsible for running a farm in Sweden’s old peasant society’? This is the question that underpins my research into life in Ramkvilla parish in the province of Småland for two hundred years (1623–1819). By conducting a detailed study of farm practice at the individual level, I have been able to analyse a complex theme that touches upon the issues of responsibility

Virus är bland de enklaste biologiska objekt i vår omgivning. Vanligen består de av en behållare av protein molekyler, en så kallad viruskapsel, som att bygga på denna viktiga insikt leder vi en bred studie av Herpesvirus där vi utforskar fysikaliska mekanismer som styr virus infektionen och ge en möjlighet till att kontrollera och även stoppa den. Dessutom öppnar studierna porten till strategierMy research area is Virus Biophysics. Research focuses on key physical mechanisms controlling replication of double-stranded DNA and RNA viruses. Experimental model systems used in my group are dsDNA bacteriophages, human Herpes viruses and Rotaviruses. I am specifically interested in physical mechanisms of genome packaging and ejection from viral capsids, viral packaging motors, DNA structural tr

Preeclampsia is a severe pregnancy-related condition that annually affects 10M women worldwide. The etiology is largely unknown and diagnosis is currently based on maternal clinical symptoms: high blood pressure and organ damage manifesting after 20 weeks of gestation. Delivery is currently the only cure. Increased long-term risk for cardiovascular diseases and stroke after preeclampsia point to i