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The many challenges of our time call for changes in regional economies, increasingly motivating scholars to dive deep into the mechanisms and possibilities for delivering such change. However, the link between regional change and people’s well-being has often been neglected, assuming that new job opportunities, green industrial path development, or higher-value economic activities are inherently g
Most parts of the Circumpolar Arctic have only discontinuous evidence for long-term human settlement. In contrast, Northern Norway has an unbroken archaeological record that extends back to the early Holocene. Numerous high-resolution archaeological and palaeoenvironmental records have been generated by commercial excavations and surveys, offering archaeologists unique opportunities to investigate
The overall purpose of this thesis was to reduce brain tissue responses around implanted microelectrodes using a pharmacological strategy. One of the main aims was to develop and evaluate drug delivery systems that allow local administration of anti-inflammatory pharmaceutics. The drug Minocycline was therefore encapsulated into biodegradable poly (D,L-lactic-co-glycolic acid) nanoparticles and th
Background: Phylogenetically closely related strains of maternally inherited endosymbiotic bacteria are often found in phylogenetically divergent, and geographically distant insect host species. The interspecies transfer of the symbiont Wolbachia has been thought to have occurred repeatedly, facilitating its observed global pandemic. Few ecological interactions have been proposed as potential rout
This paper estimates the influence that rural-to-urban commuting has on rural employment growth, and whether the strength and spatial reach of this effect depend on commuters' levels of education. A main finding is that rural-to-urban commuting has a robust positive impact on rural employment growth in services and retail. There is no significant difference in how far these effects reach into rura
The analysis of a road network could be carried out using different techniques, the most advanced of which for the identification of hazardous sites are based on a statistical tool known as a "Safety Performance Function" (SPF). SPFs are fundamental to procedures in the Highway Safety Manual (HSM) and Safety Analyst, both of which require calibration of the SPFs to local conditions. In the case of
There is a growing recognition for the need to understand how seawater carbonate chemistry over coral reef environments will change in a high-CO2 world to better assess the impacts of ocean acidification on these valuable ecosystems. Coral reefs modify overlying water column chemistry through biogeochemical processes such as net community organic carbon production (NCP) and calcification (NCC). Ho
The possibility that neuronal damage due to hypoglycemia is induced by agonists acting on the N-methyl-D-aspartate (NMDA) receptor was investigated in the rat caudate nucleus. Local injections of an NMDA receptor antagonist, 2-amino-7-phosphonoheptanoic acid, were performed before induction of 30 minutes of reversible, insulin-induced, hypoglycemic coma. Neuronal necrosis in these animals after 1
BACKGROUND: Risk factors for Parkinson's disease (PD) can be more or less relevant to a population due to population-specific genetic architecture, local lifestyle habits, and environmental exposures. Therefore, it is essential to study PD at a local, regional, and continental scale in order to increase the knowledge on disease etiology.OBJECTIVE: We aimed to investigate the contribution of geneti
Arctic homeotherms counter challenges at high latitudes using a combination of seasonal adjustments in pelage/plumage, fat deposition and intricate thermoregulatory adaptations. However, there are still gaps in our understanding of their thermal responses to cold, particularly in Arctic birds. Here, we have studied the potential use of local heterothermy (i.e. tissue cooling that can contribute to
We will consider a vector-valued Sturm-Liouville equation of the form R[U]:=-(PU')(')+QU=lambdaWU, xis an element of[0,b), with P-1, W, Qis an element ofL(loc)(1)([0,b))(mxm) being Hermitian and under some additional conditions on P-1 and W. We give an elementary deduction of the leading order term asymptotics for the Titchmarsh-Weyl M-function corresponding to this equation. In the special case o
Granath A, Norrby-Teglund A, Uddman R, Cardell L-O. Reduced iNOS expression in adenoids from children with otitis media with effusion. Pediatr Allergy Immunol 2010: 21: 1151-1156. © 2010 John Wiley & Sons A/S Nitric oxide (NO) is a key mediator in the local immune response of human airways. Inducible NO-synthases (iNOS), and endothelial NO-synthases (eNOS) are two enzymes known to regulate its
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exp
Trees growing at their altitudinal or latitudinal distribution in Fennoscandia have been widelyused to reconstruct warm season temperatures, and the region hosts some of the world’slongest tree-ring chronologies. These multi-millennial long chronologies have mainly beenbuilt from tree remains found in lakes (subfossil wood from lake-shore trees). We used aunique dataset of Scots pine tree-ring dat
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic e
This study identifies teachers’ perceptions of requirements for including collaborations with the surrounding world in their teaching practice, with the aim of providing authentic and entrepreneurial learning environments for students. School management, time and teachers’ personal character traits and disposition were the most frequently stated areas of concern, followed by colleagues, surroundin
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic e
Within the local energy independent pseudopotential theory, a convergent supercell calculation of the position of the discrete impurity level produced by the neutral undistorted vacancy in silicon has been performed. Translational symmetry was reintroduced by placing the impurities on a Bravais lattice. The author made calculations with unit cells containing up to 2662 atoms plus vacancy. A deep l
Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca(2+)-induced exocytosis in pancreatic beta-cells, an effect suggested to involve the cytosolic redox protein glutaredoxin-1 (GRX-1). We here detail the role of GRX-1 in NADPH-stimulated beta-cell exocytosis and glucose-stimulated insulin secretion. Silencing of GRX-1 by RNA interference reduced glucose-stimulated insulin secretion in b
