Filetype
European populations of the white-tailed eagle Haliaeetus albicilla suffered a drastic decline during the 20th century. In many countries, only a few dozen breeding pairs survived or the species disappeared completely. By today, the populations have recovered, naturally or through restocking (e.g. in Scotland or the Czech Republic). In the Carpathian Basin, which is now a stronghold in southern Eu
Sex differences in selection are ubiquitous in sexually reproducing organisms. When the genetic basis of traits is shared between the sexes, such sexually antagonistic selection (SAS) creates a potential constraint on adaptive evolution. Theory and laboratory experiments suggest that environmental variation and the degree of local adaptation may all affect the frequency and intensity of SAS. Here,
Species exhibiting colour polymorphism are thought to have an ecological advantage at the landscape scale, because spatial segregation of alternatively adapted ecotypes into diverse habitats can increase the species' niche breadth and thus confer greater geographic range size. However, morph frequencies are also influenced by intrapopulational processes such as frequency- or density-dependent soci
Drug therapy is often directed to specific organ and tissue compartments where the mode of action of the compound effects specifically targeted biological processes. However, the direct measurement of drug uptake in terms of a time kinetic and concentrations attained at the local sites has not been readily available as a clinical index for most drugs. A proof-of-principle study was conducted to te
BACKGROUND: To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA). METHODS: Porcine coronary arteries were treated with PTCA and immediately afterwards locally treated for 5 minutes, with a selective cytosolic guanylate cyclase inhibitor, 1 H-(1,2,4)oxadiazole(4,3-alpha)quinox
The dominating local and regional sources of gaseous and particulate air pollution in the city of Lund (69,000 inhabitants) in southern Sweden were characterized using a combination of aerosol and gas-phase monitoring techniques. Twelve-hour samples were taken at two stations of both fine and coarse fraction urban aerosols with a stacked filter unit during the four-week measurement campaign in Mar
Objective. We evaluated in a proof-of-concept double-blind placebo-controlled randomized trial the efficacy and safety of intra-articular sprifermin (recombinant human fibroblast growth factor 18) in patients with symptomatic knee OA. Methods. Sprifermin was evaluated as intra-articular injection at 10, 30, and 100μg. Primary efficacy endpoint was change in central medial femorotibial compartment
Unprecedented global challenges demand wide-reaching societal modification to ensure life support functions and human well-being. In the absence of adequate international responses to climate change and the need for place-based adaptation, local governments have a pivotal role in fostering sustainability transitions. In this context, the importance of ecosystem-based adaptation is increasingly rec
Background: Emerging data propose biomarker alteration due to clonal selection between the primary invasive breast cancer and corresponding metastases. In addition, impact on survival has been demonstrated. The present study investigates the relationship between the oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between primary ductal carcin
Purpose: To study the impact of dose fractionation of adjuvant radiation therapy (RT) on local recurrence (LR) and the relation of LR to radiation fields. Methods and Materials: LR rates were analyzed in 462 adult patients with soft tissue sarcoma who underwent surgical excision and adjuvant RT at five Scandinavian sarcoma centers from 1998 to 2009. Medical records were reviewed for dose fractiona
Background: Although transposition of the great arteries (TGA) accounts for less than 5% of congenital heart disease, the clinical course is often dramatic with need for early diagnosis and careful preoperative care as well as advanced surgical correction and postoperative support. Since 1993, Lund is one of the two tertiary referral centers for pediatric cardiac surgery in Sweden, with nearly 400
Capsaicin is used to investigate the role of peripheral sensory nerve fibers. In previous studies of rats treated by injection of capsaicin into the skin of the neck, 'spontaneous' lesions in the head and neck region were observed. In this study, the course of development over time, the regional distribution and the innervation of capsaicin-induced dermal lesions were assessed in young male Spragu
A pollen record obtained from a 2.2-m sediment succession deposited in a small lake in the province of Vasterbotten, north-eastern Sweden, reveals the presence of continuous forest cover since 8,500 calendar years before present (cal B.P.). Forest with abundant Pinus (pine) and Betula (birch) initially colonized the area, followed by a dominance of deciduous trees, primarily Betula, from ca. 8,000
Acute Pancreatitis (AP) is an inflammation disease that characterized by activation of protease and the innate immune system, leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and geranylgeranyltransferase) as well as NET formation in regulating recruitment of neutrophils and tissue dama
Cardiovascular diseases are accountable for almost 50 % of the mortality number in Europe which is why research on its causes is highly prioritised. For practical and ethical reasons, in vitro study models are of high importance to enable research on cardiac abnormal behaviours. To meet this issue, researchers from Imec, Belgium, developed Neuray-II, the second generation of a biocompatible chip w
Gambella is one of the regional states in Ethiopia where huge tracts of land have been leased out to domestic and international investors since the global food, fuel and financial crisis of 2007/2008. The Gambella region is also one of the most marginalized regions in Ethiopia. It has been alienated from the central politics and socio-economic activities of the state. In the past, the Gambella reg
Avian communities play a pivotal role in Arctic ecosystems and birds have become the key model taxa for climate change research. Due to funding priorities, Arctic passerines have been studied less intensively than waterfowl and shorebirds. In our study, we aim to partly fill this gap and look at the change in passerine community species composition in the Chaun River Delta in Northeast Siberia (68
Background: Incidental perforation in rectal cancer surgery is considered a risk factor for poorer oncological outcome. Most studies emanate from the era before total mesorectal excision when staging, neoadjuvant treatment and surgical technique were suboptimal. This study assessed the impact of incidental perforation on oncological outcome in a cohort of patients with optimized management. Method
The use and promotion of pesticides is on the increase in many sub-Saharan African countries, including in the smallholder sector. This paper stems from placed-based research in Uganda and aims at advancing current knowledge on smallholder farmers' motivations for pesticide use, the extent and character of such use, as well as on lived experiences regarding the impacts of pesticides. Data was gene
