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The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern molecules. Extracellular histones belong to the latter group and their release has been described to contribute to the induction of systemic inflammatory reactions. However, little is known about their functions in the early immune response to an
Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similaritie
Water balances for a re-vegetated xerophyte shrub (Caragana korshinskii) area were compared to that of a bare surface area by using auto-weighing type lysimeters during the 1990-1995 growing seasons at the southeast Tengger Desert, Shapotou, China. The six-year experiment displayed how major daily water balance components might vary for a bare and a re-vegetated sand dune area. Evapotranspiration
The atmospheric fallout of DDT and DDE (ΣDDT) over Sweden has decreased during the last decade. Today long-range transport from southern sources outside the country dominates the inflow. This was reflected in a decreasing south-to-north gradient of the compounds in atmospheric deposition and in the lower atomosphere. The fallout of PCBs was similar in 1984–1985 and 1972–1973, and today local conta
The alpha-adrenoceptor-mediated contractile effects of noradrenaline (alpha 1 + alpha 2), phenylephrine (alpha 1) and clonidine (alpha 2) on human saphenous veins were investigated in vivo and in vitro. By infusion (0.3 ml min-1) of the drugs (increasing concentrations in the infused solution) into distended (40 mmHg) saphenous veins in six healthy subjects, local vasoconstriction was induced, mea
Using tritium and helium-3 data for calibration, a 2-D transport model was set up to explain the occurrence of bentazone, dichlorprop, glyphosate, isoproturon, MCPA and metamitron in a small groundwater catchment in southern Sweden. The model was parameterised with site-specific degradation and sorption data to enable transport simulations. Local climatological data and a 21-year record of agricul
Flowing water impacts bridges over rivers primarily in two ways: (1) hydrodynamic forces that directly impact the structure and (2) scouring at piers and abutments, including contraction scour. The design prin-ciples for bridges in Sweden, including both impacting forces and local scour, are relatively simplistic. The purpose of this paper is to examine the impact of extreme river flows on bridges
Conservation and consistency are fundamental properties of discretizations of conservation laws, necessary to ensure physically meaningful solutions. In the context of systems of nonlinear hyperbolic conservation laws, conservation and consistency additionally play an important role in convergence theory via the Lax-Wendroff theorem. Here, these concepts are extended to the realm of iterative meth
The manuscript focuses on an original method of preparation of metatitanic acid when only environmentally safe base substances are used in the synthesis process. The synthesis is based on the reaction of solid titanyl sulfate in an aqueous solution of sodium hydroxide. This method allows for (i) a full preservation of the morphology of the starting titanyl sulfate and (ii) a preparation of metatit
Cancer är en av de vanligaste dödsorsakerna hos västerlänningar. Prostatacancer i sig utgör den näst vanligaste tumören hos män över hela världen. I två tredjedelar av fallen är prostatacancer inte livshotande. Den sista tredjedelen kan botas fullständigt förutom om metastaserna sprids för långt ifrån körteln till resten av kroppen. Den här formen av tumörer är lämplig för fotodynamisk terapi (PDTInterstitial photodynamic therapy is a local solid cancer treatment technique that relies on the simultaneous presence of light, photosensitizer and oxygen. SpectraCure AB has been developing a light delivery system for prostate cancer therapy. The use of this instrument is meant to be extended to other solid tumor treatments such as cancer in the pancreas or the ear, nose and throat tract. The co
In low-and middle-income countries, inadequate sanitation results in faecal contamination of the water used by urban farmers for irrigation. Consumers of raw contaminated vegetables run the risk of developing diarrhoeal diseases and helminth infections, which are a leading cause of under-five mortality and impact the well-being and productivity of millions of adults. This review identifies the evi
SafeGrowth is a method in urban planning to prevent crime and promote social cohesion. The method was officially introduced in Toronto, Canada in 2001. Toronto and their application of SafeGrowth sparked global interest and in 2020, Drottninghög in Helsingborg, Sweden, decided to apply the method. They became the first city in Europe to apply SafeGrowth. This study explores the application of Safe
Full-Service iPS Generation Full-service generation of novel iPS lines can be ordered. The ethical approval of collecting patient samples for reprogramming is the responsibility of the users laboratory and a copy must be provided to the core. The starting cell material from patients/donors may be from skin biopsies, peripheral blood, cord blood, etc. We currently use the Sendai reprogramming syst
https://www.stemcellcenter.lu.se/core-facilities/lund-stem-cell-center-esips-facility/services - 2026-07-09
Green prescribing, the referral of patients to nature-based activities, has potential to bring co- benefits for psychological and physiological public health and for environmental health. Literature considers a major limitation to its effective implementation as a holistic, transectoral practice to be lack of a common language and tendency of actors involved to work within their respective paradig
As a researcher, there are a number of platforms and services where you can publish your research data. It is important to choose the right place so that your research reaches the right audience, but also meets current standards and requirements. Research data publishing servicesWhen publishing research data, you can use general services or subject-specific options.Swedish National Data Service (S
Background: To demonstrate extended protection against meningococcal serogroup B (MenB) disease after MenB-FHbp (bivalent rLP2086) vaccination, this study evaluated immunopersistence through 26 months following MenB-FHbp boosting after 2 or 3 primary doses in adolescents. Study design: This phase 3, open-label study was an extension of 3 phase 2 studies with participants aged 11–18 years randomize
Objective: Medical crises occur rather seldom in the primary care setting, but when they do, initial management impacts on morbidity and mortality. Factors that impede the performance of emergency interventions in primary care have not been studied through in-situ simulation. Checklists reportedly improve crisis management. Design: This randomized controlled trial evaluated emergency intervention
Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. Ever since the early 2000’s, no major improvement of patient outcomes occurred. Immu
Background: Anal cancer is a rare disease, which might be the reason for the "one size fits all" approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contemporary pattern of recurrence studies are needed. Methods: Consecutive anal cancer patients, all treated with curative intent intensity-modulated radiotherapy (IMRT), were retrospect
BACKGROUND: There is limited evidence of the effects of local anesthesia (LA) on outcomes of non-surgical periodontal treatment (NSPT), in particular among the Chinese. This retrospective cohort study aimed to evaluate the effects of LA on short-term treatment outcomes of NSPT and to determine under what circumstances LA should be prescribed to improve these outcomes. METHODS: Data from periodonta
