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Background and objective: The European Council advises evaluating the feasibility of organized prostate cancer testing (OPT) programs, but it is unclear whether results from screening trials can be replicated in population-based testing. The aim of this study is to compare magnetic resonance imaging (MRI) assessments and biopsy outcomes with and without a central review in two Swedish OPT programs
Oligometastatic squamous-cell carcinoma of the anus (omSCCA) is a very rare condition. The literature is sparse, and treatment guidelines are lacking. The aim of the present work was to carry out a literature review and to propose an algorithm for intensified treatment of patients with omSCCA. A PubMed search was carried out, which resulted in 15 relevant publications that included any type of def
Pluvial flood mapping is a common way to identify locations at risk of being flooded in connection with an extreme short-duration rainfall. As rainfall extremes are expected to intensify in a warmer climate, more and more cities and municipalities are performing pluvial flood mapping, in Sweden and elsewhere. Often a rainfall with a return period of 100–200 years is used in the mapping, and the ma
Background: In light of increasing therapeutic options, risk stratification of advanced cardiac transthyretin amyloidosis (ATTR-CA) is gaining clinical importance to avoid ineffective treatments. Liver stiffness as a marker of hypervolemia and hepatic congestion might predict mortality in advanced ATTR-CA and allow to identify patients at highest risk. Methods: Proven ATTR-CA patients underwent re
Background: Sundbyberg municipality (part of greater Stockholm) has reconstructed a traditional two-lane road, with an allowed speed limit of 30 km/h, into a road with one car lane and two bicycle lanes, one on either side of the car lane (a “two minus one road”). The aim was to increase traffic safety and accessibility, especially for bicyclists and pedestrians Method: The design used was a befor
Climate warming exacerbates the degradation of the mountain cryosphere, including glacier retreat, permafrost degradation, and snow cover reduction. These changes dramatically alter the local and downstream hydrological regime, posing significant threats to basin-scale water resource management and sustainable development. However, this issue is still not adequately addressed, particularly in moun
Background: Urinary tract infection (UTI) in infants is a common, potentially life-threatening bacterial infection, and must be managed carefully through the entire chain of care from diagnosis, choice of treatment, follow-up and risk stratification of future complications. This Swedish nationwide study of infant UTI was conducted to evaluate the current management of infant UTI, yield of investig
Recent land-use changes have led to a significant loss of natural wetlands worldwide resulting in increased amounts of organic and inorganic compounds reaching lakes and coastal areas. In turn, this has led to an increased algal growth, and subsequently the risk of algal blooms and deteriorated water quality. The capacity of wetlands to retain nutrients is well-known, suggesting that constructed w
The structure and thermoacoustic instability (TI) of premixed CH4/H2/air swirling flames were experimentally investigated for a range of hydrogen fraction (ηH2) up to 80% under different equivalence ratio (Φ) and swirl number (S) conditions. It is shown that the onset of TI is enhanced when increasing either ηH2, S, or Φ. The dominant frequency of TI increases dramatically with ηH2. The higher dom
Projecting land-use allocation under various scenarios can be useful for reconciling conflicts between urbanization, food security, and ecological integrity throughout landscapes, but existing approaches often fail to capture the interactions in land systems that occur across scales and within and between hierarchical jurisdictions of societal organization. This article introduces a cross-scale fu
This study investigates the spatiotemporal development of the Surface Urban Heat Island (SUHI) in Malta, and compares it with Zaragoza, Spain, as an inland reference site of the same Köppen climate classification. High-resolution summer Land Surface Temperature (LST) data from 2013 to 2025, along with Impervious Surface Area (ISA), Land Use/Land Cover (LULC), and NDVI data were used to analyse the
My thesis is part of an overall environmental program evaluating the environmental and human health stress in areas of Nicaragua affected by anthropogenic emission of metals and man-made organic substances. I examine the fluvial transport of mercury contextually associated with the extent of the contamination and the observed human and environmental stress in a gold mining area. Field measurements
Objective: Cytokine-induced recruitment of leukocytes is an early feature during arterial injury and atherosclerotic plaque formation. The aim of this study was to analyze the role of the beta(2)-integrin lymphocyte function-associated antigen-1 (LFA- 1; CD11a/CD18) in cytokine-triggered firm leukocyte adhesion to arterial endothelium in vivo. Material and Methods: Intravital fluorescence microsco
A rectangular, straight microchannel heat sink with multiple length bifurcation has been designed, and the corresponding laminar flow and thermal performance have been investigated, numerically. Five different cases with multiple length bifurcation and various arrangements are investigated, as well as one case without bifurcations. All laminar fluid flow and surface heat transfer results are obtai
Popular Abstract in Swedish Senpleistocen nedisningshistoria på Nordöstgrönland: kosmogen exponeringsdatering, isutbredning och isdynamik Under den senaste istiden var periodvis stora delar av landmassorna på norra halvklotet istäckta. Idag är den Grönländska inlandsisen den enda större återstoden av detta, men likväl binder den tillsammans med isen i Antarktis och jordens mindre glaciärer väldigtThe aim of this thesis was to use cosmogenic exposure dating to investigating whether highly weathered landscapes in the Northeast Greenland fjord zone have developed during prolonged ice free conditions or have been preserved beneath cold-based ice. Previous work along the Northeast Greenland coast has presented two conflicting hypotheses for the extent of the Greenland Ice Sheet during the last
Molecular dynamics simulations have been performed on lipase B from Candida antarctica (CalB) in its native form and with one or two oxidized residues, either methionine oxidized to methionine sulfoxide, tryptophan oxidized to 5-hydroxytryptophan, or cystine oxidized to a pair of cysteic acid residues. We have analyzed how these oxidations affect the general structure of the protein as well as the
Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of asthma, and neutralization of TNF-alpha is an effective therapy for inflammatory diseases. The present study tested the idea that a TNF-alpha antibody, infliximab, may be useful in the management of asthma. E3 rats were immunized with ovalbumin (OVA)/alum and received infliximab intra-peritoneally. Two weeks later,
The Sheinwoodian succession of Gotland comprises the Högklint, Tofta and Hangvar Formations and most of the Slite Group. The succession consists of hierarchically ordered shallow marine depositional cycles, produced by orbitally forced climate changes. During warmer and wetter intervals (climate maxima) more carbonate was produced than during the cooler and dryer climate minima. Higher carbonate p
Capsule Nest survival rates could not be explained by distance to habitat edges or other features used by predators. Aims To investigate if predation on Redshank nests was affected by habitat characteristics at a local scale. Methods We examined survival rates of Redshank nests on coastal meadows on the Baltic island of Gotland, Sweden, over two breeding seasons. We analysed nest survival rates
Evidence has accumulated that apoptotic cell death contributes to brain damage following experimental seizures. A substantial number of degenerating neurons within limbic regions display morphological features of apoptosis following prolonged seizures evoked by systemic or local injections of kainic acid, systemic injections of pilocarpine and sustained stimulation of the perforant path. Although
