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The microbiota colonizes each barrier site and broadly controls host physiology1. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection2. The unique strategies used at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive. Here we uncover that, in the skin, host-microbiota symbiosis depends on the
Correlations among conserved quantum numbers, such as the net-electric charge, the net-baryon, and the net-strangeness in heavy-ion collisions, are crucial for exploring the QCD phase diagram. In this paper, these correlations are investigated using net-proton number (as a proxy for the net-baryon), net-kaon number (for the net-strangeness), and net-charged particle number in Pb-Pb collisions at =
The molecular mechanisms governing internal fluctuations in intrinsically disordered protein (IDP) assemblies are crucial to the stability and dynamics of both regulated and aberrant toxic cellular aggregates, but remain poorly understood. By comprehensively combining high-resolution quasi-elastic neutron scattering with all-atom molecular dynamics simulations, we probe the motions of β-casein, a
For multi-vehicle complex traffic scenarios in shared spaces such as intelligent intersections, safe coordination and trajectory planning is challenging due to computational complexity. To meet this challenge, we introduce a computationally efficient method for generating collision-free trajectories along predefined vehicle paths. We reformulate a constrained minimum-time trajectory planning probl
Under sen Trias inträffade flera globala miljöförändrigar, inclusive klimatinstabilitet, och den mest markanta var det biotiska utdöendet vid Norian-Rhaetian-gränsen (NRB). Stora karbonatplattformar etablerades längs tethyshavet och exporterade periodvis karbonat-sediment till det angränsade havsbottnet, särskilt på bathyalt djup. Petrografisk analys av elva prover från sex density flow-avlagringaDuring the late Triassic period several global environmental changes took place, including climate instability, and the most distinctive one was the biotic extinction at the Norian – Rhaetian boundary (NRB). Large carbonate platforms were established along the Tethys ocean and periodically exported carbonate sediments to the adjacent ocean floor, and especially at the bathyal depth. Petrographic
The immature rat ovary contains VIP immunoreactive nerve fibres sparsely distributed around blood vessels, in the interstitial gland and around follicles. The VIP concentration, measured radioimmunologically, decreased significantly after PMSG treatment (10 i.u.), probably due to ovarian enlargement and oedema, while the total VIP content (total of 0.12 pmol in both ovaries) did not change after P
Methods of analysing and interpreting two-dimensional velocity field data in order to understand the scales of turbulence of bubbly two-phase flow were developed. Reynolds decomposition and large eddy simulation (LES) decompositions (low-pass filtering), in conjunction with proper orthogonal decomposition (POD) energy spectra analysis, as well as adjusted convective decomposition (constant convect
A prospective bacteriologic investigation was made in 43 consecutive patients (mean age 63 years) operated on for acute cholecystitis. Gallbladder bile and wall were cultured, using four methods and with special attention to optimal anaerobic technique. Cultures were positive in 72% of the patients, yielding a wide variety of species (21 species among 48 isolates). Anaerobes constituted 23% of the
In Sweden today, power production with bioenergy systems is more costly than with fossil energy systems. New technology under development, such as integrated gasification and combined cycle technology (IGCC), and reduced biomass costs would improve the competitiveness of bioenergy systems. The CO2 mitigation costs are lower for biomass systems using IGCC technology than for natural gas systems usi
A microstructural study of mortars prepared with a low-alkali, low-C3A cement and a Class F fly ash, both of Swedish origin, was carried out using the scanning electron microscopy - energy-dispersive X-ray analytical technique. Supplementary phase analyses were made by X-ray diffraction and thermogravimetry -differential thermal analysis. Normally, CH crystals in the transition zone grow with thei
Fuel cells are promising for future energy systems, since they are energy efficient and, when hydrogen is used as fuel, there are no emissions of greenhouse gases. Fuel cells have during recent years various improvements, however the technology is still in the early phases of development, this can be noted by the lack of dominant design both for singe fuel cells, stacks and for entire fuel cell sy
We used a crossing experiment to investigate post-zygotic barriers that might limit introgression between a pair of closely-related, gynodioecious plant species - the widespread weed Silene vulgaris and the local Swedish endemic S. uniflora ssp. petraea. The study not only considered the effects of hybridization on conventionally-used (primary) fitness components such as seed set and progeny survi
IL-8 is a major human neutrophil chemoattractant at mucosal infection sites. This study examined the C-X-C chemokine response to mucosal infection, and, specifically, the role of macrophage inflammatory protein (MIP)-2, one of the mouse IL-8 equivalents, for neutrophil-epithelial interactions. Following intravesical Escherichia coli infection, several C-X-C chemokines were secreted into the urine,
The transition from a middle Holocene relatively warm and stable climate to a cooler and unstable late Holocene climate is reconstructed using sediments from Lake Igelsjon, south-central Sweden. This multiproxy study illustrates local, regional and global scale responses to climatic change by focusing on a previously identified abrupt hydrological shift to cooler and/or wetter conditions around 40
This essay is about the indigenous people Urak Lawoi in Andaman Sea, outside the west coast of Thailand. The study shows what happens to them when they are being deprived of their territory and are being forced to abandon their culture, lifestyle and traditional economic subsistence. Urak Lawoi have until recently maintained culture, language and lifestyle apart from the rest of Thai society. Dur
Direct gene transfer to the adult brain is dependent on vectors that transduce non-dividing cells, such as lentiviral vectors. Another aspect of the development of gene therapy to the brain is the need for cell-specific transgene expression. Expression from vesicular stomatitis virus G-protein (VSV-G) pseudotyped lentiviral vectors has been reported to be mainly neuron specific in the brain. We co
The present study concerns 73 patients with known unilateral breast carcinoma. Thirty of the patients had a primary invasive carcinoma removed and at a later operation contralateral subcutaneous mastectomy with implantation of a prosthesis. This was performed with or without ipsilateral breast reconstruction. Forty-three of the cases had an in situ carcinoma found by local excision, whereafter bil
The Swedish cue word men ‘but’ can mark the boundary between both different topic units as well as topic-internal units in spontaneous speech. The goal of this study is to see if these two functions of men can be distinguished on the basis of their local prosodic correlates and co-occurring lexical items. Men-tokens in spontaneous narrations were labelled as to their function, first using text-onl
The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood. To investigate whether beta-amyloid (Abeta) associated microglia are derived from blood monocytes, we transplanted BM cells from enhanced green fluorescent protein expressing mice into young or old transgenic AD mice and determined the engraftment of BM-derive
