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Background: During rectal cancer surgery the bowel may contain viable, exfoliated cancer cells, a potential source for local recurrence (LR). The amount and viability of these cells can be reduced using intraoperative rectal washout, a procedure that reduces the LR risk after anterior resection. The aim of this study was to analyse the impact of washout on oncological outcome when performed in Har
Despite large industrial relevance, the relation between rotor-stator geometry, hydrodynamics and drop breakup is poorly understood, partly since no methods for measuring the fragmenting stresses acting on drops have been established. This study attempts to bridge this gap by developing, applying and evaluating two approaches for estimating local turbulent stresses based on particle image velocime
The fast-increasing demand and relatively slow growth of infrastructure capacity are providing a strong motivation for research in real-time urban traffic controls that make the best use of novel sensing in order to increase efficiency and resilience of the transportation system. In our contribution, we focus on a class of dynamic feedback traffic signal control policies that are based on a genera
Strålbehandling är en av de vanligaste metoderna för att behandla cancer. I den mest använda formen av strålbehandling används en strålkälla utanför kroppen, så kallad extern strålterapi. Ett alternativ är att ge behandlingen med hjälp av ett läkemedel till vilket man har kopplat ett radioaktivt ämne, så kallad radionuklidterapi. Det radioaktiva läkemedlet ansamlas i tumören och ger där en intern In radionuclide therapy (RNT), radioactive pharmaceuticals are administered for therapeutic purposes. Dosimetry, i.e. the estimation of the absorbed dose to various targets, can potentially lead to a better understanding of the therapeutic effects in RNT and allow for individualization of the therapy. However, dosimetry is seldom used in RNT clinical practice, and several problems degrade the info
PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of pre
With the triumph of the codex, medieval literature became more deeply hermeneutic in character. A vast range of texts, in various languages and genres, were not only copied with the commentaries and glosses of ancient tradition, but also underwent continuous reworking and transformation. Indeed, the very act of transcribing texts into a manuscript was often an incentive to rewrite them. This pract
The case of Vietnam, represented by the different development paths between Tonkin and Cochin-China, shows the complexity of analysis of the impact of colonialism. Population density was not the organizing principle behind the settlement of French colonialists. Nor did it significantly determine the level of extraction as expected by AJR’s theory. On the contrary, we show that the presence of seve
Poly(arylene ether sulfone)s containing randomly distributed biphenyl units tethered with precisely six imidazolium cations are designed and prepared with the aim to facilitate ionic clustering and conductivity of anion exchange membranes (AEMs). A series of statistical copolymers with different cationic contents are synthesized via K2CO3-mediated polycondensations of 2,2′,3,3′,5,5′-hexamethyl-4,4
We investigate the momentum and energy budget of stellar feedback during different stages of stellar evolution, and study its impact on the interstellar medium (ISM) using simulations of local star-forming regions and galactic disks at the resolution affordable in modern cosmological zoom-in simulations. In particular, we present a novel subgrid model for the momentum injection due to radiation pr
Background: Policy implementation in the context of health systems is generally difficult and the Kenyan health sector situation is not an exception. In 2005, a new health sector strategic plan that outlines the vision and the policy direction of the health sector was launched and during the same year the health sector was allocated a substantial budget increment. On basis of these indications of
During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a
Background Breast-conserving surgery (BCS) followed by radiotherapy (RT) is an established treatment for women with T1-2N0 breast cancers. Since subgroups of patients have low ipsilateral breast tumour recurrence (IBTR) rates, it is important to study whether RT is necessary for all patients. Patients and methods A total of 1187 women with primary T1-2N0M0 breast cancer were randomised, after stan
The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity me
Understanding why species richness peaks along the Andes is a fundamental question in the study of Neotropical biodiversity. Several biogeographic and diversification scenarios have been proposed in the literature, but there is confusion about the processes underlying each scenario, and assessing their relative contribution is not straightforward. Here, we propose to refine these scenarios into a
The effect on axonal outgrowth of inhibition of phospholipase A2 activity was studied in a recently developed in vitro model, where dorsal root ganglia with attached spinal roots and nerve stumps from young adult mice were cultured in an extracellular matrix material (Matrigel). The phospholipase A2 inhibitors 4-bromophenacyl bromide and oleyloxyethyl phosphorylcholine dose-dependently reduced axo
The aim of this chapter is to discuss the possibilities of a critical realist sociology of law set against the background of the work of Professor Karsten Åström. Thus, in the next section I give a short description of Åström’s ”sociolegal stance”, and specifically his concept of parallel norm creating processes. I then proceed, in the third section, to describe the basics of Roy Bhaskar’s critica
Global teaching and learning for sustainable development reaches from the classroom to the world outside, and is therefore a particularly interesting setting for practising transition skills. The article suggests a number of features perceived as crucial in developing young people's capability to act in a changing world and under circumstances that are difficult to predict. The suggestions are bas
Objective: The aim of this study was to create a preoperative prediction model predicting extraprostatic tumour growth in men with clinically organ-confined disease from a prospectively collected Swedish cohort. Materials and methods: The study used data from 3386 men in the prospective multi-centre Laparoscopic Prostatectomy Robot Open (LAPPRO) trial, with 14 participating urological departments.
We present mid-infrared laser-induced thermal grating spectroscopy (IR-LITGS) using excitation radiation around 3 μm generated by a simple broadband optical parametric oscillator (OPO). Acetylene as a typical small hydrocarbon molecule is used as an example target species. A mid-infrared broadband OPO pumped by the fundamental output of a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser was
Objectives: This study aimed to investigate the effects of adding adjunct mechanical imaging to mammography breast screening. We hypothesized that mechanical imaging could detect increased local pressure caused by both malignant and benign breast lesions and that a pressure threshold for malignancy could be established. The impact of this on breast screening was investigated with regard to reducti
