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Strålbehandling är en av de vanligaste metoderna för att behandla cancer. I den mest använda formen av strålbehandling används en strålkälla utanför kroppen, så kallad extern strålterapi. Ett alternativ är att ge behandlingen med hjälp av ett läkemedel till vilket man har kopplat ett radioaktivt ämne, så kallad radionuklidterapi. Det radioaktiva läkemedlet ansamlas i tumören och ger där en intern In radionuclide therapy (RNT), radioactive pharmaceuticals are administered for therapeutic purposes. Dosimetry, i.e. the estimation of the absorbed dose to various targets, can potentially lead to a better understanding of the therapeutic effects in RNT and allow for individualization of the therapy. However, dosimetry is seldom used in RNT clinical practice, and several problems degrade the info

With the triumph of the codex, medieval literature became more deeply hermeneutic in character. A vast range of texts, in various languages and genres, were not only copied with the commentaries and glosses of ancient tradition, but also underwent continuous reworking and transformation. Indeed, the very act of transcribing texts into a manuscript was often an incentive to rewrite them. This pract

During the course of this three-year project, we have studied aeolian deposits at 70 sites within sixteen areas in south-central Sweden. Inland dunes have been the focus, but some sites with coversand and coastal dunes have also been investigated. We have mapped dune morphology, mainly by LiDAR-based remote sensing, studied the internal sediment architecture by ground-penetrating radar profiling a

Purpose Adjuvant carboplatin is one of three management strategies that may follow inguinal orchiectomy in clinical stage I seminoma. However, little is known about the outcome of patients who experience a relapse after such treatment. Patients and Methods Data from 185 patients who relapsed after adjuvant carboplatin between January 1987 and August 2013 at 31 centers/groups from 20 countries were

Aims. We aim to study the variability properties of bright hard X-ray selected active galactic nuclei (AGN) in the redshift range between 0.3 and 1.6 detected in the Chandra Deep Field South (XMM-CDFS) by a long (∼3 Ms) XMM observation. Methods. Taking advantage of the good count statistics in the XMM CDFS, we search for flux and spectral variability using the hardness ratio (HR) techniques. We al

BACKGROUND: Tuberculosis (TB) is the leading cause of death for individuals infected with Human immunodeficiency virus (HIV). Conversely, HIV is the most important risk factor in the progression of TB from the latent to the active status. In order to manage this double epidemic situation, an integrated approach that includes HIV management in TB patients was proposed by the World Health Organizati

Objective: To present the baseline data of the international TuberOus SClerosis registry to increase disease Awareness (TOSCA) with emphasis on the characteristics of epilepsies associated with tuberous sclerosis complex (TSC).Methods: Retrospective and prospective patients' data on all aspects of TSC were collected from multiple countries worldwide. Epilepsy variables included seizure type, age a

ABSTRACT: BACKGROUND: Bone grafts are frequently used in orthopaedic surgery. Graft remodelling is advantageous but can occur too quickly, and premature bone resorption might lead to decreased mechanical integrity of the graft. Bisphosphonates delay osteoclastic bone resorption but may also impair formation of new bone. We hypothesize that these effects are dose dependent. In the present study

Background and purpose: Studies on accelerated fractionation (AF) in head and neck cancer have shown increased local control and survival compared with conventional fractionation (CF), while others have been non-conclusive. In 1998 a national Swedish group decided to perform a randomised controlled clinical study of AF. Materials and methods: Patients with verified squamous cell carcinoma of the o

Popular AbstractStörre kriser och katastrofer som stormen Gudrun och dess konsekvenser är sannolikt att vänta i framtiden. Det råder dock ovisshet om vilka kriserna kommer att vara och under vilka förutsättningar. Nya och kompletterande vetenskapliga studier och metoder inom kris- och katastrofforskningen måste till för att öka samhällets kunskap om och förmåga att hantera kända och okända hotbildSevere crises and disasters such as the Hurricane Gudrun and their consequences will probably occur in the future. However, there are many uncertainties concerning disasters and their effects. New scientific approaches and methods for crisis and disaster research must be developed to increase the knowledge and ability of societies to manage known and unknown threats. Substantial research on the em

Growing research on social capital and health has fuelled the debate on whether there is a place effect on health. A central question is whether health inequality between places is due to differences in the composition of people living in these places (compositional effect) or differences in the local social and physical environments (contextual effects). Despite extensive use of multilevel approa

Popular Abstract in Swedish Blodbildningen är en av kroppens livligaste processer. Varje dag bildas det upp mot en triljon (12 nollor!) mogna blodceller. De röda blodkropparna står för transporten av syre, de vita blodkropparna försvarar mot infektioner och trombocyterna deltar i blodlevringen. Bildningen av blodceller sker i benmärgen och kan liknas vid ett träd, där roten utgörs av de så kalladeGranulocyte-macrophage- (GM-) and granulocyte- (G-) colony stimulating factor (CSF) are important cytokines in the regulation of hematopoiesis and for the function of mature blood cells. They are also involved in the cytokine network regulating the inflammatory and immune response. The aim of this study was to investigate the regulation of GM- and G-CSF production at the cellular level. The studie

Popular Abstract in Swedish Denna doktorsavhandling syftar till att identifiera och tolka förändringar i den marina miljön, avspeglade i Gotlands siluriska berggrund. Silurperioden (ca 444-416 miljoner år sedan) har traditionellt beskrivits som ett tidsintervall med ett varmt växthusklimat och hög global havsnivå med små miljömässiga förändringar i den marina miljön. Under det senaste decenniet haThis thesis treats the Silurian carbonate platforms of Gotland, Sweden, which formed close to the equator within the East Baltic Basin. Three different time intervals, all involving changes in facies composition and structure of the platforms, have been studied; Late Homerian, latest Homerian ? earliest Gorstian, and late Ludfordian, respectively. Two of the intervals, the Late Homerian and the la

Popular Abstract in Swedish Respiratorbehandling i hemmet till patienter med kronisk underventilering (som kan bero på flera olika grundsjukdomar) har blivit allmänt accepterad, eftersom behandlingen kan ge symptomlindring och förbättrad överlevnad. Syfte: Att undersöka vilka behandlingsmotiv som föranleder start av respiratorbehandling i hemmet och att kvantifiera effekterna av behandlingen på pHome mechanical ventilation in patients with chronic respiratory failure secondary to several different diseases has become widely acceptable as the provision of ventilatory support can provide symptomatic relief and increase life expectancy. Aims: To study the selection criteria underlying the initiation of home mechanical ventilation and to quantify the effects of in relation to blood gases and

BACKGROUND: Oxygen free radicals (OFRs), platelet activating factor (PAF), cell adhesion molecules, and transmigration of polymorphonuclear leukocytes through the gut barrier are probably all essential in the development of gut barrier dysfunction following intestinal ischemia and reperfusion (I/R). Pretreatment and early treatment of I/R with the OFRs-scavenger (NAC), the PAF inhibitor lexipafant

This study aims to demonstrate the potential of a process-based regional ecosystem model, LPJ-GUESS, driven by climate scenarios generated by a regional climate model system (RCM) to generate predictions useful for assessing effects of climatic and CO2 change on the key ecosystem services of carbon uptake and storage. Scenarios compatible with the A2 and B2 greenhouse gas emission scenarios of the

Questions Can the model performance of the landscape reconstruction algorithm (LRA) for small forest hollows be validated through comparison to inventory-based vegetation reconstructions from the last 150yrs? Does the application of LRA and the comparison to historical data enhance interpretation of the pollen record? Location Denmark. The Gribskov-Ostrup small forest hollow (56 degrees N, 12 degr

Context. To be able to investigate the chemical history of the entire Milky Way, it is imperative to also study its dust-obscured regions in detail, as this is where most of the mass lies. The Galactic Center is an example of such a region. Due to the intervening dust along the line of sight, near-infrared spectroscopic investigations are necessary to study this region of interest.Aims. The aim of

The concentrations of gas-phase potassium hydroxide (KOH), potassium chloride (KCl) and atomic potassium (K(g)) were quantitatively measured from the near-surface to downstream area of burning pinewood pellets by a newly developed photofragmentation tunable diode laser absorption spectroscopy (PF-TDLAS) technique to reveal the original form of the released potassium. The novel arrangement of the P

During the year 2008, the government offered a number of different municipalities in Sweden a development agreement. The purpose of the agreement was to reduce the number of districts in Sweden, where a high proportion of residents feel a sense of exclusion, poor health and insecurity. In connection with the development agreement the Crime Prevention Council and the Statistics Office produced stat