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Accurate prediction of urban land use changes at fine spatial scales is essential for developing healthy and sustainable cities, yet traditional simulation models struggle to capture local dynamics due to limited availability of fine-grained data and insufficient complexity in modeling urban systems. To address these limitations, we propose a novel approach that leverages advances in pre-trained v
Context: Pollen-mediated gene flow is crucial for ecological and evolutionary processes and understanding its disruption by anthropogenic disturbances is essential for conservation. Objectives: In this study, we developed landscape connectivity metrics that incorporated hummingbird movement behaviour to assess how structural (amount and configuration) and functional (species-specific behavioural r
Growing evidence of the microbiome's importance for plant ecology highlights the need for conservation strategies that consider both plants and their microbial partners, the holobiont. Population genomics are valuable tools for designing conservation strategies but rarely accounts for host- or site-specific microbial interactions. Orchids, with their dependence on specific mycorrhizal fungi, exemp
INTRODUCTION: Ventilator-associated pneumonia (VAP) is the most frequent healthcare-associated infection in intensive care units and is associated with high morbidity and mortality. Current diagnostic criteria lack specificity, leading to misclassification and unnecessary antibiotic use. Identifying patient subgroups with a common pathophysiological basis (pneumoclusters) may distinguish true VAP
In a time marked by growing environmental and societal challenges, where multiple planetary boundaries are being crossed, the way we conduct business practices needs to be rethought. Regenerative business models offer a path towards a more responsible future by incorporating strategies that go beyond net zero and focus on actively restoring the natural and social systems they operate in, creating
Streptococcus pneumoniae is a bacterium of great global importance, responsible for more than one million deaths per year. This bacterium is commonly acquired in the first years of life and colonizes the upper respiratory tract asymptomatically by forming biofilms that persist for extended times in the nasopharynx. However, under conditions that alter the bacterial environment, such as viral infec
Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR
Background: The tumoricidal complex alpha1-oleate targets bladder cancer cells, triggering rapid, apoptosis-like tumor cell death. Clinical effects of alpha1-oleate were recently observed in patients with non-muscle invasive bladder cancer (NMIBC), using a randomized, placebo-controlled study protocol. Aims: To investigate if there are dose-dependent effects of alpha1-oleate. Materials and Methods
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-associated changes in the composition and metabolism of the mouse gut microbiota. We observed several taxonomic-level changes on day (D)7 post-infection, including
Using firm-level data from 15 European countries between 2011 and 2019, this paper examines the productivity effect associated with the development of Artificial Intelligence (AI), measured by patenting success in AI fields. By making advances in AI and expanding on their knowledge base, companies can optimise production tasks, and improve resource utilisation, ultimately leading to higher levels
Objective: Determine participants’ satisfaction with rehabilitation following total laryngectomy (TL) and investigate associations between dysphagia, voice problems, and possible explanatory variables. Methods: 172 Danish and Swedish participants having received a TL 1.6–18.1 years ago for laryngeal/hypopharyngeal cancer answered a questionnaire regarding satisfaction with rehabilitation following
Objective: To describe the epidemiology of injuries and illnesses sustained during the Beijing 2022 Paralympic Winter Games, organised in a closed-loop environment to adhere with COVID-19 restrictions. Methods: Injuries and illnesses from all teams were recorded on a daily basis by team medical staff on a web-based form and by local organising committee medical (polyclinic) facilities and venue me
Objectives: To investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette-Guérin (BCG) infections after adjuvant BCG instillations in patients with non-muscle-invasive bladder cancer (NMIBC). Patients and Methods: We analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nat
Background: The molecular content of urine is defined by filtration in the kidneys and by local release from tissues lining the urinary tract. Pathological processes and different therapies change the molecular composition of urine and a variety of markers have been analyzed in patients with bladder cancer. The response to BCG immunotherapy and chemotherapy has been extensively studied and elevate
Wall-bounded turbulence is relevant for many engineering and natural science applications, yet there are still aspects of its underlying physics that are not fully understood, particularly at high Reynolds numbers. In this study, we investigate fully developed turbulent pipe flows at moderate-to-high friction velocity Reynolds numbers ( 361 ≤ R e τ ≤ 2000 ), corresponding to bulk velocity-based Re
Background and purpose: Recent progress in diagnostics and treatment of metastatic cancer patients have improved survival substantially. These developments also affect local therapies, with treatment aims shifting from short-term palliation to long-term symptom or disease control. There is consequently a need to better define the value of stereotactic body radiotherapy (SBRT) for the treatment of
A model that simulates surface moisture content on sandy beaches for aeolian transport applications is developed and integrated into the aeolian transport model AeoLiS. The moisture content of a thin surface layer (≈2 mm thickness) is computed as a function of wave runup, precipitation, evaporation, percolation, and capillary rise from the groundwater table. The groundwater table is simulated usin
Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system. Methods: In this local institutional review board–approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 m
Introduced social insects can be highly invasive outside of their native range. Around the world, the introduction and establishment of the eusocial bumblebee Bombus terrestris (L. 1758) (Hymenoptera: Apidae) has negatively impacted native pollinators and ecosystems. Understanding how morphological variation is linked to environmental variation across invasive ranges can indicate how rapidly speci
Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1–4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5–7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neol
