Filetype
Purpose: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been repor
Popular Abstract in Swedish Denna studie diskuterar trygghet och rädsla för brott i åtta kommuner i Åboland, men även kriminalitet och förövare i området samt den särpräglade sociala kontroll som råder i de åtta kommunerna. Studien fortsätter två forskningsspår ? det ena om brottslighetens och rädslans former i områden som upplevs som trygga av sina invånare och det andra om trygghet och oräddhet This study examines safety and fear of crime in Åboland, a predominantly rural area in southwestern Finland. It also examines crime and criminals in the area, as well as the distinctive social control that characterises Åboland's eight municipalities. The study continues two strands of research, the first about criminality and fear of crime in societies that are considered safe by their inhabitant
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf
BACKGROUND: Prostate cancer cells secrete unique proteases such as prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) that represent targets for the activation of prodrugs as systemic treatment of metastatic prostate cancer. Previously, a combinatorial peptide library was screened to identify a highly active peptide substrate for hK2. The peptide was coupled to an analog of the
Introduction: A state of hypercoagulation and fibrinolytic dysfunction is present in individuals with diabetes, which may contribute to disturbed skin microcirculation and impaired ulcer heating. We have previously reported an improved outcome of chronic diabetic foot ulcers during treatment with dalteparin. In the present study we investigated the effects of dalteparin on skin microcirculation an
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact
This dissertation deals with the rental relations in Malmö between 1880 – 1925. This period witnessed extensive changes in Swedish society, including on the housing market. Industrialization and the rapid pace of urbanization created the basis for a housing market with a strong speculative element. Tenement housing made its breakthrough in Malmö around the turn of the 20th century. New housing are
Vitreoscilla is an obligate aerobic bacterium found in oxygen-poor environments such as stagnant ponds and decaying vegetable matter. Vitreoscilla induces the production of a homodimeric hemoglobin (VHb) when subjected to oxygen-limiting conditions. It is thought that VHb facilitates oxygen delivery to the respiratory apparatus of its host by increasing the local oxygen concentration under oxygen-
Popular Abstract in Swedish Många grundläggande processer i naturen involverar transport av energi från ett ställe till ett annat. Ett exempel på detta är fotosyntesen där solljus fångas upp av molekylkomplex, för att sedan transporteras till ett reaktionscenter. I reaktionscentret byggs den laddning upp som sedan används för att framställa växtmassa. För att minimera energiförlusten i den här typAn efficient transfer of energy in molecular systems has proven to be of fundamental importance both in nature and industrial applications. The ability of molecules to work together forming collective excitations, so-called excitons, plays a key role in for example the extraordinary fast energy transfer involved in the first steps of photosynthesis. The characterization of excitonic states in conj
Popular Abstract in Swedish Statistik handlar om att beskriva slumpmässiga händelser. Genom att bygga matematiska modeller för hur slumpen beter sig kan man beräkna hur troliga olika händelser är. Skilda ämnen har nytta av olika slags slumpmodeller, men slumpens lagar är universella! Därför kan en slumpmodell som utvecklats inom ett ämne senare visa sig användbar inom ett helt annat. Min avhandlinThis thesis explores models and algorithms in geostatistics and gene mapping. The first part deals with the use of computationally effective lattice models for inference of data with a continuous spatial index. The fundamental idea is to approximate a Gaussian field with a Gaussian Markov random field (GMRF) on a lattice, and then to conduct a bilinear interpolation of this at non-lattice location
Pollinator populations have suffered severe declines in many industrialised countries due to reduced floral and nesting resources, brought on by agricultural intensification. One potential method of mitigating these effects is creating flower strips. Most previous studies have shown higher pollinator abundances in flower strips, but none have been able to demonstrate increased pollinator abundance
Experimental studies have shown that remodelling of the atrial myocardium is linked to the occurrence and perpetuation of atrial fibrillation (AF). Clinical evidence, however, is insufficient. We recorded monophasic action potentials (MAP) during AF from one to three sites in the right atrium in seven patients with chronic AF (CAF) and in 11 patients with paroxysmal AF (PAF). The fibrillatory (FF)
The detection of the formyl radical (HCO) is of great interest in the field of combustion research since it can provide information about the local heat release (HR) rate which is a key parameter in the understanding of combustion processes. Unfortunately, due to the low signal level, HCO planar laser-induced fluorescence (PLTF) has so far not been applicable for single-shot imaging, which is nece
Biological and physical processes in the Arctic system operate at various temporal and spatial scales to impact large-scale feedbacks and interactions with the earth system. There are four main potential feedback mechanisms between the impacts of climate change on the Arctic and the global climate system: albedo, greenhouse gas emissions or uptake by ecosystems, greenhouse gas emissions from metha
PURPOSE: Identification of risk factors of poor oncological outcome in rectal cancer surgery is of utmost importance. This study examines the impact of incidental perforation on the oncological outcome. METHODS: Using the Swedish Rectal Cancer Registry, patients were selected who received major abdominal surgery for rectal cancer between 1995 and 1997 with registered incidental perforation. A cont
Arachidonate 15-lipoxygenase (LO)-1 has been implicated in allergic inflammation and asthma. The overall effect of 15-LO in allergic inflammation in vivo is, however, unclear. This study investigates systemic allergen sensitization and local allergic airway inflammation and remodeling in mice lacking the murine 12/15-LO, the ortholog to human 15-LO-1. Upon systemic sensitization with intraperitone
Downscaled climate model projections from phase 5 of the Coupled Model Intercomparison Project (CMIP5) were used to force a dynamic vegetation agricultural model (Agro-IBIS) and simulate yield responses to historical climate and two future emissions scenarios for maize in the U.S. Midwest and wheat in southeastern Australia. In addition to mean changes in yield, the frequency of high- and low-yiel
OBJECTIVE: Systemic effects of carbon dioxide (CO(2)) insufflation during left-sided cardiac surgery were evaluated in a prospective randomized study, with regard to acid-base status, gas exchange, cerebral hemodynamics, and red blood cell morphology. METHODS: Twenty patients undergoing elective left-sided cardiac surgery were randomized to de-airing procedure either by CO(2) insufflation techniqu
The present study employs square cross-section ribbed channels with different arrangements of downstream half-size ribs to determine the most optimal configurations for augmenting heat transfer rates with minimized pressure drop penalties. The channel inlet Reynolds number ranges from 20,000 to 160,000. The influence of downstream ribs arrangement on the overall performance characteristics of ribb
Popular Abstract in Swedish Upptäckten av Helicobacter pylori (Hp) (1982) har revolutionerat synen på uppkomsten av såväl magsår, magkatarr som magsäckskancer. Idag vet vi att Hp är en mycket starkt bidragande orsak till samtliga dessa sjukdomar och är en av våra vanligaste sjukdomsframkallande bakterier. Epidemiologiska studier har visat att mellan 50 och 80% av jordens befolkning är smittad. I SHelicobacter pylori and Borrelia burgdorferi s.l. can cause chronic infections by evading the immune system. These two human pathogens express a number of immunogenic cell surface proteins. The aims of this study were to gain further knowledge about these antigens and to analyse the serum antibody response in infected individuals. Both invasive and non-invasive diagnostic methods are available for
