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A particularly well-studied evolutionary model is the vinegar fly Drosophila melanogaster, a cosmopolitan insect of ancestral southern-central African origin. Recent work suggests that it expanded out of Africa ∼9,000 years ago, and spread from the Middle East into Europe ∼1,800 years ago. During its global expansion, this human commensal adapted to novel climate zones and habitats. Despite much w
BackgroundColorectal cancer with overgrowth into urinary organs requires en-bloc resection of involved organs to achieve negative resection margins (R0). This study investigates survival and oncological outcomes after colorectal cancer surgery with resections of urinary organs.MethodPatients undergoing colorectal cancer surgery with urological resection in Sweden 2007–2018 were identified via the
This study presents an integrated simulation framework that combines agent-based transport modeling with probabilistic load-flow analysis to quantify power system loading of long-haul heavy-duty electrification. The approach is applied to a case study considering fully electrified road freight in the Skåne region in Sweden, using high-resolution transport demand data and the actual power grid mode
Sustainable bioenergy is central to climate change mitigation, yet biomass supply depends not only on biophysical and economic assessments but also on farmers' decision-making. Straw from cereal and oilseed crops can support renewable energy, but its availability is constrained by on-farm uses, management practices, and farmers' access to knowledge of sustainable soil management. Because straw rem
Photosynthetic water oxidation catalyzed by Photosystem II takes place at a site that comprises a redox-active tyrosine, YZ, a tetramanganese cluster, and, in addition to its redox components, two inorganic cofactors, calcium and chloride. Recent work suggests that YZ and the metal site are intimately linked in the oxidation and deprotonation reactions of substrate water. The metal cluster stores
Popular Abstract in Swedish Resenärernas värderingar av kvalitet i lokal kollektivtrafik – hur man kan mäta dem, hur de varierar och hur man kan använda dem i planeringen Syftet med arbetet har varit att ta fram ett mer detaljerat underlag för planering av lokal kollektivtrafik. Med mer kunskap om hur olika grupper av resenärer värderar olika delar av en kollektivtrafikresa kan kollektivtrafiknätThe aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire
BACKGROUND: Leucocyte recruitment and inflammation are key features of high dose radiation-induced tissue injury. The inflammatory response in the gut may be more pronounced following radiotherapy due to its high bacterial load in comparison to the response in other organs. We designed a model to enable us to study the effects of radiation on leucocyte-endothelium interactions and on intestinal mi
Popular Abstract in Swedish I denna avhandling studeras den akuta inflammatoriska reaktionen i huden. Akut inflammation beskrevs redan under romersk tid av Aulus Cornelius Celsus. Han karakteriserade denna reaktion med rodnad, svullnad, värme och smärta. Fysiologiskt består akut inflammation av vidgning av små blodkärl (vasodilatation) som ger upphov till rodnad samt av läckage av plasmaproteiner This thesis examines the microvascular inflammatory response in the skin. The microvascular response includes vasodilatation and plasma exudation. In the first three studies, the combined response was measured in guinea pig skin with a technique based on detection of radiolabelled protein. Transferrin was labelled in vivo by injection of 113mIn and the conversion electrons detected over the skin u
Background. The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion and minimize mechanical forces during the digestion process. The isolation protocol has also been modified to meet current GMP (cGMP) standards. Moreover, the impact of donor- and process-related factors was correlated to the use of islets f
Popular Abstract in Swedish Då en struktur utsätts för varierande belastning kan brott uppstå vid väsentligt lägre last än vad som hade orsakat brott vid konstant lastnivå. Fenomenet kallas utmattning och berör många traditionella ämnen. För att kunna göra relevanta bedömningar av livslängden vid utmattningsbelastning krävs kunskap om materialets egenskaper, både mikroskopiskt och makroskopiskt, tThis thesis deals with different aspects of fatigue crack propagation in IN718. The ultimate objective of the work is to gain understanding of the fatigue process, from the macroscopic stress-strain relations to microscopic fatigue crack growth mechanisms. First, the stress-strain relations, which are fundamental in order to understand what the material encounter, are dealt with. The high temperat
The main topic of this thesis is the investigation of atomic andmolecular adsorbates on single crystal surfaces of silicon and aluminiumusing the techniques of scanning tunnelling microscopy (STM) andspectroscopy (STS). The emphasis has been to use atomic-resolutionspectroscopy and imaging to determine the relationship between thesurfaces' geometric and electronic structures. The STM results have
Popular Abstract in Swedish DNA är en molekyl som finns närvarande i stan alla celler och den innehåller den genetiska koden för utvecklingen av alla former av liv. Molekylen är väldigt tunn (2 nanometer i diameter) och lång - mänskligt DNA skulle vara ca en meter lång i utsträckt tillstånd. Inuti cellerna antar DNA en superkompakt struktur för att få plats inuti en cellkärna med bara ca 10 mikromThe structure, hydration, and dynamics of concentrated DNA-amphiphile complexes were investigated by small-angle X-ray diffraction, sorption calorimetry, and nuclear magnetic resonance. A concentrated, electroneutral, DNA-amphiphile complex can be formed by mixing charge-stoichiometric solutions. The effect is a strong association of DNA with the oppositely charged amphiphile resulting in the form
Popular Abstract in Swedish Grupp B streptokocker (GBS) är den vanligaste orsaken till blodförgiftning, lunginflammation och hjärnhinneinflammation i nyföddhetsperioden. Ungefär en fjärdedel av alla kvinnor är koloniserade (bärare) genitalt av GBS under graviditeten och förlossningen. Hälften av barnen till dessa kvinnor blir smittade av bakterien i samband med födseln, men bara en liten del av deInfection with group B streptococcus (GBS), an encapsulated bacterium, is an important cause of neonatal morbidity and mortality. Capsular polysaccharides and cell surface proteins of GBS are candidate antigens for development of a human GBS vaccine. Proteins have many advantages as vaccine antigens. The majority of the neonatal infections are caused by strains of capsular serotypes Ia, Ib, II, II
Popular Abstract in Swedish Det doktorandarbete som framläggs av Pawel Brühl handlar om flera aspekter av ett framgångsrikt genomfört bullerskyddsarbete i en stor svensk industri med mycket hög bullernivå (Volvos pressverk i Olofström). Man har genomfört ett program bestående av bullermätningar, bullerreduktion med flera metoder samt studium av automatiseringens konsekvenser. Arbetstagarna har fåtThe design and implementation of a hearing conservation programme in a heavy industry with high noise levels is described. Action was taken on several points, including noise measurements, noise reduction, education on hearing protector use, and audiometric monitoring. It was found that the noise at the plant has been greatly reduced during a period of 25 years. The reduction in noise was made pos
Popular Abstract in Swedish Strålbehandling är en av de vanligaste behandlingarna mot cancer. Hälften av alla behandlingar syftar till att bota patienten från sjukdomen, men strålbehandling är även en mycket effektiv behandling för att lindra smärta och andra symptom för patienter med en obotlig cancer. Förberedelse inför strålbehandling är en komplicerad procedur, som innefattar många olika teknPreparation for radiotherapy is a complex procedure that involves many different technologies and groups of professionals. The rapid development and introduction of new technologies throughout the last decade have made it possible to deliver highly conformal, individually-shaped dose distributions with high accuracy. However, there is widespread concern that current quality assurance practices hav
Objective: The aim of this study is to identify risk factors for the loss of measurable plasma C-peptide in newly diagnosed 15- to 35-year-old diabetic subjects. Methods: This Swedish study included 778 subjects. C-peptide levels were obtained each year for 6 years after diagnosis. Loss of measurable C-peptide was defined as a level at or below the lower detection limit of the local assay (0.13 nm
Objective: To evaluate the safety and endometrial protection of low-dose transdermal estradiol (E2)/norethisterone acetate (NETA) patches (Estalis 25/125) in terms of post-treatment incidence of endornetrial hyperplasia/cancer after 1 year of treatment in postmenopausal women with intact uteri. Methods: Patients were randomized to receive either transdermal E2/NETA (delivering daily doses of E2 25
Flow characteristics and heat transfer performances of rectangular dimpled channels with secondary protrusions are numerically analyzed and compared in this research work. The special arrangement is a conventional dimpled cavity with a small-size secondary protrusion placed upstream of the dimple. The objective is to determine the most optimal configuration for augmenting heat transfer rates with
AIMS: Although childhood obesity is becoming increasingly prevalent, treatment options are limited and the continued development of effective treatment strategies is necessary. It is equally important to explore involvement of other resources in society, such as sports associations. This study was designed to investigate the possibility of reducing the degree of obesity in obese children by focusi
Availability of safe, edible food is essential. Food shortage has caused many wars and encouraged people to try to preserve food for a longer time, allowing storage and transport, often in some kind of package/container. The USA showed the way in developing the food sector and already prior to the 2nd World War they had self-service stores filled with packed goods. Europe, however, had to wait to
