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Group A streptococcus (GAS) is a major bacterial pathogen responsible for both local and systemic infections in humans. The molecular mechanisms that contribute to disease heterogeneity remain poorly understood. Here we show that the transition from a local to a systemic GAS infection is paralleled by pathogen-driven alterations in IgG homeostasis. Using animal models and a combination of sensitiv

We study the effects of local vertex corrections to the self-energy of the electron gas. We find that a vertex derived from time-dependent density-functional theory can give accurate self-energies, provided, however, a proper decay at large momentum transfer (large q) is built into the vertex function. (The local-density approximation for the vertex fails badly.) Total energies are calculated from

The GeoPIXE software for quantitative PIXE trace element imaging and analysis is a well established package for evaluation of characteristic X-ray data for both PIXE and SXRF. For the case of microbeam applications on semi-thick samples knowledge of the local areal density distribution is important for precise quantification. A technique is reported to achieve this using the measurement of beam pa

Incentive-based conservation has become a significant part of how tropical forests are being governed. Reducing emissions from deforestation and forest degradation (REDD+) is a mechanism to mitigate climate change that many countries have started to implement. REDD+, however, is criticized for its potential negative impacts on local populations and Indigenous people. To prevent and mitigate the ne

Myocardial dysfunction occurs commonly in septic shock. It is not known whether this is due to local ischaemia and metabolic disturbances. Our hypothesis was that endotoxaemic myocardial dysfunction may be associated with interstitial ischaemic and metabolic changes, measured using interstitial microdialysis (MD). Methods: Eighteen pigs were randomized to control (n=6) or endotoxin infusion (n=12)

Policymakers have made several attempts to introduce local and national policies to reduce CO2 emissions and stimulate the consumer adoption of alternative fuel vehicles (ethanol/E85 cars). The purpose of this paper is to analyze how a local policy measure impacts the composition of the car fleet over time. More specifically, we take advantage of the natural experiment setting caused by the introd

Sediments from the small lake Ilsø situated in the Illerup/Alken Enge Valley were studied in order to investigate past landscape development at the time of a probably ritual human mass burial following battle during the Roman Iron Age (ad 1–400). A pollen record from Ilsø and a number of other records from Jutland were combined using the Landscape Reconstruction Algorithm to reconstruct local vege

AIMS: This study assessed radiotherapy combined with capecitabine and oxaliplatin in patients with primary, inextirpable colorectal adenocarcinoma. PATIENTS AND METHODS: Forty-nine patients entered the trial. Two cycles of XELOX (capecitabine 1000mg/m(2) bid d1-14+oxaliplatin 130mg/m(2) d1, q3w) were followed by radiotherapy (50.4Gy), combined with capecitabine 825mg/m(2) bid every radiotherapy da

This study investigates whether privately funded aid projects enable a more effective development compared to publicly run, with the perspectives of local street-level bureaucrats at focus. The purpose is to highlight aid workers as much of policy is being formed and put into practice at street-level rather than policy level in developing countries. New emerging actors on the aid arena also calls

In the present study, the effects of a single rib on the local heat transfer around a bluff body are examined by using the steady state liquid crystal technique. By varying the spacing between the bluff body and the rib, the interaction between the rib and the bluff body can be controlled. The bluff body is oriented vertically towards the flow direction and spans the whole height of the channel. T

In this master’s thesis I have explored what characterises the setting of dolmens and passage graves in north-eastern and south-eastern Scania, southern Sweden, if there are common features, and what meaning/connection the setting can imply. By combining field visits at twenty-four sites with search results from the Swedish National Heritage Board’s database, map studies, literature studies and pr

Popular Abstract in Swedish Små kyrkor i länder som domineras av andra religioner är ofta beträngda idag. I Malaysia växer sig Islam starkt, och islamistiska rörelser med terroristiska metoder omger landet på alla sidor. Samtidigt har även Buddhism och Hinduism fått nytt liv. Genomgående märks en skärpt hållning visavi den kristna kyrkan och en tilltagande kritik av proselytism. Från Väst finns inProtestantism in Malaysia is in many cases the result of labour migration from China and India in the 19th and 20th Centuries. Under the British colonial administration, it enjoyed a certain degree of protection. Furthermore, in the 20th Century, many Western missions started work in Malaysia often in order to strengthen and expand the ministry of existing denominations. This was particularly true

PURPOSE: By analysing collected data using theory, we aim to interpret the design, implementation and the usage of BSC in NPO’s to be able to contribute to the research. METHODOLOGY: A case study design has been made through semi-structured interviews and backed up by a quantitative survey and internal documents. THEORETICAL PERSPECTIVES: Based on the sources given from the creators of the scoreca

Within many-body perturbation theory, we apply vertex corrections to various closed-shell atoms and to jellium, using a local approximation for the vertex consistent with starting the many-body perturbation theory from a Kohn-Sham Green's function constructed from density-functional theory in the local-density approximation. The vertex appears in two places-in the screened Coulomb interaction W an

The goal of this contribution is to stimulate a wider reflection on the role of food consumption practices throughout prehistory. We focussed on the Jōmon communities of Hokkaidō Island in Northern Japan since these mobile foragers underwent a process of economic diversification and intensification, eventually leading to higher levels of sedentism across the Pleistocene-Holocene transition. Moreov

Universities are powerful drivers to create and advance knowledge on sustainable development. Furthermore, they can be used as a controlled environment to apply innovative technologies and approaches. This process also embraces industry and government, in the triple helix innovation model, as in the University of Campinas (Unicamp), Brazil—one of the best Latin American universities (3rd)—and imme

Citizen science is changing society's contribution to research projects worldwide. Non-experts are no longer just spectators, they are active participants and supporters of scientific work. Using citizen science, that is, data collected by laypeople, the opportunities to collect large-scale data on the environment are increasing. Such community-based and citizen scientific approaches can provide u