Search results

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation cells Article Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar * and Alessandro Fiorenzano * Citation: Nilsson, F.; Storm, P.; Sozzi, E.; Hidalgo Gil,

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_cells.pdf - 2026-05-22

Deepened knowledge on response of biota and ecological processes following fire is essential for a future with warmer climate and more disturbances. In 2014 the first mega-fire (13,100 ha) for at least a century in Scandinavia hit south-central Sweden, in a production forest landscape shaped by clearcutting forestry. Ecological dynamics is followed in >20 projects from universities, authorities an

Easy, low‐threshold access is widely regarded as a major advantage of online services. In Sweden, several municipalities are striving to increase the accessibility of their social services by responding to anonymous users online. This article considers the nature of the accessibility of these online services. Two online platforms were studied: (quasi‐)synchronous online chats and asynchronous onli

Microservice applications consist of a set of smaller services interacting in a graph structure to deliver the full application. Jobs will traverse this graph in different paths, both depending on the type of job, but also on the current load of different service replicas. Different paths will incur different scenario-specific costs, dependent on, e.g., deployment and the underlying cloud system.

In this paper we study two major challenges in few-shot bioacoustic event detection: variable event lengths and false-positives. We use prototypical networks where the embedding function is trained using a multi-label sound event detection model instead of using episodic training as the proxy task on the provided training dataset. This is motivated by polyphonic sound events being present in the b

This work presents examples from processing and interpretation of 2576 km of SkyTEM data in the Ringsted-Suså groundwater mapping area located southeast of Denmark. The mapping area is approx. 422 km2 and includes approx. 75,000 SkyTEM soundings. Additionally, diverse ground based geophysical data (>260 km Multi-Electrode Profiling (MEP), > 130 km Pulled-Array Continuous Electrical Soundings (PACEThis work presents examples from processing and interpretation of 2576 km of SkyTEM data in the Ringsted-Suså groundwater mapping area located southeast of Denmark. The mapping area is approx. 422 km2 and includes approx. 75,000 SkyTEM soundings. Additionally, diverse ground based geophysical data (>260 km Multi-Electrode Profiling (MEP), > 130 km Pulled-Array Continuous Electrical Soundings (PACE

PURPOSE: To analyze real-world graft survival and visual acuity outcomes of corneal transplantation in Europe. SETTING: Corneal clinics in 10 European Union member states, the United Kingdom, and Switzerland. DESIGN: Multinational registry study. METHODS: All corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry (ECCTR) were identified. Graft survival of

To evaluate the potential use of tree-ring data as a proxy for fire activity at the scale of a large boreal region, we analyzed a set of regional tree-ring chronologies of Siberian larch (Larix sibirica L.), a spatially implicit annual fire record, and monthly climate data for the Komi Republic for the period 1950-1990. In most years, annually burned area was below 0.001% of the republic's foreste

**Mindre data, bättre mat: Konsten att gissa rätt med statistik** Att ställa om till hållbar mat är dyrt och riskabelt. Företag förlitar sig på smakpaneler, men med få provsmakare blir resultaten ofta osäkra gissningar. Detta examensarbete visar att avancerad sannolikhetslära kan vaska fram guld ur små datamängder. Men nyckeln till framgång var oväntad: för att fatta bättre beslut måste vi våga tConsumer sensory panels are the gold standard for evaluating food products, yet they often suffer from small sample sizes and sparse, ordinal data. Standard frequentist methods for analyzing this data (e.g. ANOVA, McNemar's test) often violate assumptions or lack statistical power. This thesis evaluates the efficacy of Bayesian Hierarchical Models (BHMs) with cumulative link likelihoods for an

Easy and low-threshold access is considered to be a major advantage of online services. In Sweden, social services in several municipalities strive to increase their accessibility by responding to anonymous users online. This paper raises the question about the nature of accessibility that the online social services entail. Two online platforms were studied: synchronous online chats and asynchrono

Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis

The interactions of sodium dodecyl sulfate (SDS) with chemically cross-linked gels of ethyl(hydroxyethyl) cellulose (EHEC) were studied. Above the so-called critical association concentration (cac), binding of SDS gives rise to an increased swelling of the EHEC gels. The binding of SDS to the gels was measured with flame emission analysis of the sodium ion. The self-diffusion of the surfactant ion

Today independent publishers are offering digital libraries with fulltext archives. In an attempt to provide a single user-interface to a large set of archives, the studied Article-Database-Service offers a consolidated interface to a geographically distributed set of archives. While this approach offers a tremendous functional advantage to a user, the fulltext download delays caused by the networ

Predictive models used in decision making, such as QSARs in chemical regulation or drug discovery, call for evaluated approaches to quantitatively assess associated uncertainty in predictions. Uncertainty in less reliable predictions may be captured by locally varying predictive errors. In the current study, model-based bootstrapping was combined with analogy reasoning to generate predictive distr

The laterally and mutually constrained inversion (LCI and MCI) techniques allow for the combined inversion of multiple geophysical datasets and provide a sensitivity analysis of all model parameters. The LCI and MCI work with few-layered models, and are restricted to quasi-layered geological environments. LCI is used successfully for inversion of surface wave (SW) seismic data and MCI for combined

Background and aims: As part of an RCT in six European sites, the direct mental health care cost for 422 patients with schizophrenia was analysed according to how total and medication costs differed across sites and which variables were likely to predict total or service-specific costs. Method: Service use was recorded continuously during a 12-month follow-up. Prescribed psychotropic medication wa

Objectives: Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Previously we reported that maggot excretions/secretions (ES) break down Staphylococcus aureus biofilms but do not kill the bacteria. As many antibiotics are not effective against biofilms we assessed the effect of combinations of ES and antibiotics on S. aureus biofilms and on the survival of the bac

How should a pedagogical agent in educational software be designed to support student learning? This question is complex seeing as there are many types of pedagogical agents and design features, and the effect on different student groups can vary. In this paper we explore the effects of designing a pedagogical agent’s self-efficacy in order to see what effects this has on students´ interaction wit

OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate impaired hand function. METHODS: The patients were randomized to mitt use or no mitt use on the less af

Software inspections are an efficient method to detect faults in software artefacts. In order to estimate the fault content remaining after inspections, a method called capture-recapture has been introduced. Most research published in fault content estimations for software inspections has focused upon point estimations. However, confidence intervals provide more information of the estimation resul