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In patients with intermediate or high grade non-Hodgkin lymphoma (NHL), third generation chemotherapy regimens have been introduced to improve survival in comparison with the standard CHOP regimen. However, most studies have found no difference between these two treatments. We conducted a meta-analysis to assess the effectiveness of third generation regimens as compared with CHOP. Our study includ

The local ground geomagnetic field fluctuations (AB) are dominated by high frequencies and 83% of the power is located at periods of 32 min or less. By forming 10-min root-mean-square (RMS) of A B a major part of this variation is captured. Using measured geomagnetic induced currents (GIC), from a power grid transformer in Southern Sweden, it is shown that the 10-min standard deviation GIC may be

The survivable network design problem is a classical problem in combinatorial optimization of constructing a minimum-cost subgraph satisfying predetermined connectivity requirements. In this paper we consider its geometric version in which the input is a complete Euclidean graph. We assume that each vertex v has been assigned a connectivity requirement r(upsilon).. The output subgraph is supposed

Despite improved treatment results of childhood acute lymphoblastic leukemia (ALL), 20% to 30% have a relapse, and then the outcome is very poor. We studied 40 children with ALL marrow relapse piloting an ALL relapse protocol with well-known drugs and drug combinations by using a concept of response-guided design. We also measured response in logarithmic fashion. Our primary end points were achiev

OBJECTIVE: To explore the long-term benefits of shortened constraint-induced movement therapy (CIMT) in the subacute phase poststroke. DESIGN: A 1-year follow-up after shortened CIMT (3h training/d for 2 wk) where the participants had been randomized to a mitt group or a nonmitt group. SETTING: A university hospital rehabilitation department. PARTICIPANTS: Poststroke patients (N=20, 15 men, 5 wome

ObjectivesTo assess the in vitro antibiotic susceptibility of Enterococcus faecalis in biofilms.MethodsE. faecalis isolates were from infections of prosthetic hip and knee joints. Minimal biofilm eradication concentrations (MBECs) for ampicillin, vancomycin, linezolid, ciprofloxacin and rifampicin, alone and in combinations, were determined. E. faecalis biofilms in microtitre plate wells or on bea

Long-term instability in multiplanet exosystems is a crucial consideration when confirming putative candidates, analysing exoplanet populations, constraining the age of exosystems and identifying the sources of white dwarf pollution. Two planets that are Hill stable are separated by a wide-enough distance to ensure that they will never collide. However, Hill-stable planetary systems may eventually

Introduction: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). Material and method

A continuous integrated bioprocess available from the earliest stages of process development allows for an easier, more efficient and faster development and characterization of an integrated process as well as production of small-scale drug candidates. The process presented in this article is a proof-of-concept of a continuous end-to-end monoclonal antibody production platform at a very small scal

Rationale: The topic of sparse representation of samples in high dimensional spaces has attracted growing interest during the past decade. In this work, we develop sparse representation-based methods for classification of radiological imaging patterns of breast lesions into benign and malignant states. Methods: We propose a spatial block decomposition method to address irregularities of the approx

Operant conditioning chambers are used to perform a wide range of behavioral tests in the field of neuroscience. The recorded data is typically based on the triggering of lever and nose-poke sensors present inside the chambers. While this provides a detailed view of when and how animals perform certain responses, it cannot be used to evaluate behaviors that do not trigger any sensors. As such, ass

PURPOSE: To investigate the survival of heart transplant (HTx) recipients during different time periods in Sweden. We hypothesized that the survival for HTx recipients has improved following advancements in the management of these patients. METHODS: Data was obtained through the database of the organ exchange organization Scandiatransplant. All patients who underwent HTx in Sweden between Jan 1988

Contamination of the water and sediment with per- and polyfluoroalkyl substances (PFAS) was studied for the lake impacted by the release of PFAS-containing aqueous film forming foam (AFFF). PFAS concentrations were analyzed in lake water and sediment core samples. ΣPFAS concentrations were in the range of 95-100 ng L-1 in the lake water and 3.0-61 µg kg-1 dry weight (dw) in sediment core samples,

Heltäckande riskbedömning av kontaktallergiframkallande ämnen med cellbaserade metoden GARD®skin Metoden GARD®skin identifierar kontaktallergiframkallande ämnen med hög noggrannhet. Genom att sätta koncentrationen mot svarsvärdet av GARD®skin i en dos-responskurva kan metoden potentiellt utvecklas för att även klassificera styrkan och effektiviteten av ämnens förmåga att orsaka kontaktallergi. Allergic contacts dermatitis is a major health problem in the world and the disease is caused by a type IV hypersensitivity to a small chemical called a hapten. These substances are common in cosmetics, perfumes, pharmaceuticals and house-hold products, and risk factors include both inherent factors and frequent or high exposure. Hazard assessment and potency classification of sensitizers are ther

This study examines the experiences of four women being a part of a separatist space for women and transgender people creating music digitally and working with music production. For the four informants, the separatist context has been perceived as a safe space. Through interviews we find out about the informants' different experiences. All four feel that they have been strengthened by having b

There is a need for validated instruments measuring emotion regulation strategies that are developed particularly for adolescents. The aim of the study was to explore the psychometric properties of the further developed scale entitled, Adolescents’ Emotion Regulation Strategies Questionnaire, version 2(AERSQ:2), developed at Lund university. Through convenience sampling, 239 adolescents (Mage = 14