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Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered a better marker for early cobalamin depletion than total cobalamin. However, in elderly populations, health-related reference intervals for holoT

Objective The development of non-Hodgkin's lymphoma (NHL) confers a high risk of mortality in primary Sjogren's syndrome (pSS) patients, but the sensitivity and specificity of proposed lymphoma predictors are insufficient for practical use. The performance of lymphoid organisation in the form of germinal centre (GC)-like lesions was evaluated in labial salivary gland biopsies taken at pSS diagnosi

In the study reported here we examined the short-term effects (1-3 years) of slash retention (SR) and the long-term effects (13-15 years) of wood-ash application (A) on fine roots and mycorrhizae in a 40-year-old Norway spruce forest in southwest Sweden. Soil cores were used to obtain estimates of the biomass (g m(-2)) of roots in three diameter classes (< 0.5, 0.5-1 and 1-2 mm), root length densi

A study was undertaken to measure the effects of conspecific density on the growth, mortality and deformity rate of yellowtail kingfish Seriola lalandi Valenciennes during the first feeding period. Newly hatched larvae were stocked in replicate tanks at initial densities of 40, 60 and 100 ind. l(-1) until 30 d post-hatch (DPH). Live prey was administered at frequent intervals in an effort to maint

Background: Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. Methods: Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT scan as Lung Endpoints (EXACTLE) study (n = 65), were pooled to increase the stati

For studies of Galactic evolution, the accurate characterization of stars in terms of their evolutionary stage and population membership is of fundamental importance. A standard approach relies on extracting this information from stellar evolution models but requires the effective temperature, surface gravity and metallicity of a star obtained by independent means. In previous work, we determined

Background and Objectives. Thalidomide modulates the production of tumor necrosis factor (TNF-alpha). Soluble TNF receptors, TNFR p55 and TNFR p75, modify TNF-a activity. In this study, we explored the relation between soluble TNF receptors and outcome in patients with advanced multiple myeloma treated with thalidomide. Design and Methods. The levels of soluble TNF receptor p55 and p75 were assess

A new sampling method, termed negligible depletion hollow fiber-protected liquid-phase microextraction, was developed for sensing the freely dissolved concentration (C free) and evaluating the availability of atrazine (ATR), desethyl atrazine (DEA), and simazine (SIM) in water. The sampling device was prepared by impregnating 1-octanol to both the pores and the lumen of a piece of polypropylene mi

Popular Abstract in Swedish Bakgrunden till den här avhandlingen är att man vill utveckla en ny mammografimetod, som utnyttjar ultraljud. När en tunn stråle av kontinuerligt ultraljud träffar en partikel, till exempel en blodkropp, som rör sig, så uppstår en reflektion. Frekvensen av den reflekterade signalen är inte densamma som för den utsända. Signalen har fått ett så kallat Dopplerskift, där fThe motivation to study the kind of problems appearing in this thesis has been ultrasound measurements of flows, from which velocity spectra along lines can be determined. These velocity spectra can mathematically be described by a new non-linear transform, here called the Doppler Spectral Transform (DST). The Doppler spectral transform has a very rich theory, into which some steps are taken here

Aims. We present new and improved radiative lifetimes for eight levels in HfI and 18 levels in HfII, along with oscillator strengths and wavelengths for 195 transitions in HfII. With these data we determine the abundance of hafnium in two chemically peculiar stars: the hot-Am star HR 3383 and the HgMn star chi Lupi, and discuss the implications of the new data to the hafnium abundance for the Sun

1. The present study was aimed at examining P2 receptor-mediated vasodilatation in human vessels. The isometric tension was recorded in isolated segments of the human left internal mammary artery branches precontracted with 1 muM noradrenaline. 2. Endothelial denudation abolished the dilator responses. 3. The selective P2Y1 agonist, 2-MeSADP, induced a potent vasodilatation (pEC50=6.9plusminus0.1)

Objective: Recent research in knee osteoarthritis (OA) highlights the role of the meniscus in OA pathology. Our aim was to compare the proteomes of medial and lateral menisci from end-stage medial compartment knee OA patients, with reference menisci from knee-healthy deceased donors, using mass spectrometry. Design: Tissue plugs of Ø3 mm were obtained from the posterior horns of the lateral and me

Thicker snowpacks and their insulation effects cause winter‐warming and invoke thaw of permafrost ecosystems. Temperature‐dependent decomposition of previously frozen carbon (C) is currently considered one of the strongest feedbacks between the Arctic and the climate system, but the direction and magnitude of the net C balance remains uncertain. This is because winter effects are rarely integrated

During the last decade, an active line of research in proof complexity has been to study space complexity and time-space trade-offs for proofs. Besides being a natural complexity measure of intrinsic interest, space is also an important issue in SAT solving. For the polynomial calculus proof system, the only previously known space lower bound is for CNF formulas of unbounded width in [Alekhnovich

Background: Older adults with pain have an increased risk of falling (odds ratio (OR) 1,7). Pain in Parkinson’s disease (PD) is more common than in older adults. The association between pain and falling in people with PD is poorly explored.Objective: To investigate the occurrence of pain in mild PD and its association with future falls/near fallsMethods. The study included 141 participants with PDBackground: Older adults with pain have an increased risk of falling (odds ratio (OR) 1,7). Pain in Parkinson’s disease (PD) is more common than in older adults. The association between pain and falling in people with PD is poorly explored.Objective: To investigate the occurrence of pain in mild PD and its association with future falls/near fallsMethods. The study included 141 participants with PD

Objective To estimate the additional societal costs for people living with dementia (PwD) with agitation in home care (HC) and institutional long-term care (ILTC) settings in 8 European countries. Design Cross-sectional data from the RightTimePlaceCare cohort. Setting HC and ILTC settings from 8 European countries (Estonia, Finland, France, Germany, Netherlands, Spain, Sweden, and England). Partic

Aims: TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials and Methods: We assessed the per allele impact of the rs7903146 T-allele on clinical characteristics and complication risk in 9231 individuals with type 2 diabete

BACKGROUND AND AIMS: Esophageal squamous cell carcinoma (ESCC) is the dominant histological type of esophageal cancer worldwide (90%). We aimed to provide an update of the global temporal trends in the incidence of ESCC.METHODS: Incidence data for ESCC were collected from 30 well-established cancer registries from 20 countries in Europe, Northern America, Australia, or Asia for 1970-2015. Time tre

BACKGROUND: Because parvovirus B19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality.METHODS: We established a cohort of 113 228 children born to women tested for parvovirus B19 infection during pregnancy in a major diagnostic lab

To keep global warming within 1.5 °C of pre-industrial levels, there needs to be a substantial decline in the use of coal power by 20301,2 and in most scenarios, complete cessation by 2050. The members of the Powering Past Coal Alliance (PPCA), launched in 2017 at the UNFCCC Conference of the Parties, are committed to “phasing out existing unabated coal power generation and a moratorium on new coa