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Written products and writing processes in Swedish deaf and hard of hearing children : an explorative study on the impact of linguistic background

The small body of research on writing and writing processes in the group of deaf and hard of hearing (DHH) children has shown that this group struggles more with writing than their hearing peers. This article aims to explore in what ways the DHH group differs from their peers regarding the written product and the writing processes. Participants are all in the age span 10–12 years old and include:

A World of Persons

Detta är en studie i det internationella tänkandets subjekt. Människor och stater, om än ofta betraktade som varandras motsatser, delar en sak: de är det internationella tänkandets huvudsakliga subjekt. Avhandlingens argumentet är att orsaken till detta står att finna i det språk genom vilket subjektskap artikuleras, personbegreppets språk, som stipulerar vissa kriterier – i första hand rationalitThis is a study of subjecthood in international thought. Human beings and states, while often held to be opposed to one another, share this: they are international thought’s key subjects. The following chapters attempt to answer the question of why that is. The main argument advanced is that this is because of the particular language in which subjecthood is articulated, the language of personhood,

Time Trends in Trajectories of Forearm Mineral Content and Bone Size during Childhood—Results from Cross-Sectional Measurements with the Same Apparatus Four Decades Apart

Evidence suggests that single photon absorptiometry (SPA)-measured forearm bone mineral density (BMD) is lower in contemporary children in Malmö than it was four decades ago, but the fracture incidence in the at-risk population (all Malmö children) has been stable during the same period. The aim of this study was to evaluate if improvements in skeletal structure over time may explain this observat

An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults

Frailty refers to the lack of resilience and a reduction in a person’s ability to recover following a health problem, and it is increasingly becoming a challenging aspect of ageing populations.Many older adults are exposed to polypharmacy; i.e., they continue to be on medications without timely re-evaluation. Medication reviews have proven successful in managing polypharmacy in the general populat

Acoustic Trapping in Biomedical Research

Popular Abstract in Swedish I naturen finns en närmast oändlig variation av biologiska partiklar i storleksordningen 100 nanometer till 10 mikrometer. Bland dessa kan man bland annat finna; eukaryota celler som genom ordnad samverkan bygger upp flercelliga organismer, prokaryota celler vilka lever som solitära organismer såsom olika bakterier eller jästsvamp, och viruspartiklar vilka likt parasiteHerein a method that uses acoustically resonating glass capillaries and enables non-contact capture of micron-sized bioparticles, i.e. acoustic trapping, is described. A miniaturized ultrasonic transducer is used to locally actuate a cross-sectional resonance in the capillary. A 2000×200 µm2 capillary is typically operated around a resonance frequency of 4-MHz. Optimal design of the transducer for

Exposure to Inorganic Arsenic Is Associated with Increased Mitochondrial DNA Copy Number and Longer Telomere Length in Peripheral Blood

BACKGROUND: Exposure to inorganic arsenic (iAs) through drinking water causes cancer. Alterations in mitochondrial DNA copy number (mtDNAcn) and telomere length in blood have been associated with cancer risk. We elucidated if arsenic exposure alters mtDNAcn and telomere length in individuals with different arsenic metabolizing capacity.METHODS: We studied two groups in the Salta province, Argentin

Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort

Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

Background-Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. Methods and Results-To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinct met

Expanding the genetic toolbox of Rhodotorula toruloides by identification and validation of six novel promoters induced or repressed under nitrogen starvation

Background: The non-conventional yeast Rhodotorula toruloides is an emerging host organism in biotechnology by merit of its natural capacity to accumulate high levels of carotenoids and intracellular storage lipids from a variety of carbon sources. While the number of genetic engineering strategies that employ R. toruloides is increasing, the lack of genetic tools available for modification of thi

Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels

BACKGROUND: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF. METHODS: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hi

Learning From Organizational Incidents: Resilience Engineering for High-Risk Process Environments

For years, safety improvements have been made by evaluating incident reports and analyzing errors and violations. Current developments in safety science, however, challenge the idea that safety can meaning-fully be be seen as the absence of errors or other negatives. Instead, the question becomes whether a company is aware of positive ways in which people, at all level of the organisation, contrib

Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis

Aims/hypothesis We aimed to identify which surrogate index of insulin sensitivity has the strongest correlation with the reference measurement, the hyperinsulinaemic-euglycaemic clamp (HEC), to determine which surrogate measure should be recommended for use in large-scale studies. Methods A literature search (1979-2012) was conducted to retrieve all articles reporting bivariate correlations betwee

Wildfires in boreal ecoregions: Evaluating the power law assumption and intra-annual and interannual variations

Wildfires are a major driver of ecosystem development and contributor to carbon emissions in boreal forests. We analyzed the contribution of fires of different fire size classes to the total burned area and suggest a novel fire characteristic, the characteristic fire size, i.e., the fire size class with the highest contribution to the burned area, its relation to bioclimatic conditions, and intra-

Knee malalignment is associated with an increased risk for incident and enlarging bone marrow lesions in the more loaded compartments: the MOST study

Objective: To examine the relationship of knee malalignment with occurrence of incident and enlarging bone marrow lesions (BMLs) and regression of BMLs. Methods: Subjects from the Multicenter Osteoarthritis Study aged 50-79 years with or at high risk of knee osteoarthritis were studied. Full-limb radiographs were taken at baseline and hip-knee-ankle mechanical axis was measured. Baseline and 30-mo

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91 462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followe

Interplay between AIB1 genotypes and radiotherapy in a Swedish population-based breast cancer cohort

Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)

Education, occupation and income inequalities in obesity among Portuguese women and men : Evidence from national health surveys (1998-2019)

INTRODUCTION: This study examined trends in socioeconomic inequalities in obesity among Portuguese women and men using data from National Health Surveys (NHSs).METHODS: We analysed weighted data from adults aged 20-64 years from the 1998/1999 (n = 20,581), 2005/2006 (n = 13,088), 2014 (n = 7284), and 2019 (n = 5959) NHSs. Obesity was defined as body mass index (BMI) ≥30 kg/m 2, based on self-repor

The equivocal opposite effects of lower and higher body mass index at diagnosis on radiographic joint damage progression in early rheumatoid arthritis : an inception cohort study over 15 years

Objective To investigate the effect of Body Mass Index (BMI) on long-term radiographic damage in an inception rheumatoid arthritis (RA) cohort. Methods The study population, n=1813, originated from the observational Better AntiRheumatic FarmacoTherapy cohort. X-rays of hands and feet at inclusion, 1, 2, 5, 8 and 15 years were quantified for erosion score (ES), joint space narrowing (JSN) and the s

Analysis of HLA-A, -B and -DR Alleles as Risk Factors for One-Year Mortality in Heart Transplants Using Artificial Neural Networks

Hjärttransplantationer syftar till att rädda liv men kan även vara riskabla ingrepp. Det är mycket som kan gå fel. Det transplanterade hjärtat lider stor risk att avstötas i mottagarens kropp, och en mer detaljerad kunskap om faktorerna som påverkar avstötning har således möjligheten att rädda liv. Avstötning orsakas av att mottagarens immunförsvar känner av HLA-molekylerna, där HLA står för HumThe beneficial effects of HLA matching at the HLA-A, -B and -DR loci on recipient short- and long-term survival in heart transplants have been established in a number of studies. The objective of the present study was to evaluate the importance of individual HLA alleles at the HLA-A, -B and -DR loci as risk factors for recipient death within one year after transplant by using artificial neural net

A bivariate measurement error model for nitrogen and potassium intakes to evaluate the performance of regression calibration in the European Prospective Investigation into Cancer and Nutrition study

Objectives: Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, the performance of 24-h dietary recall (24-HDR) measurements as reference measurements in a linear regression calibration model is evaluated critically at the individual (within-centre) and aggregate (between-centre) levels by using unbiased estimates of urinary measurements of nitrogen and potassium