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Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91 462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followe
Objectives: Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, the performance of 24-h dietary recall (24-HDR) measurements as reference measurements in a linear regression calibration model is evaluated critically at the individual (within-centre) and aggregate (between-centre) levels by using unbiased estimates of urinary measurements of nitrogen and potassium
We report on the multi-wavelength observations of PKS 1510-089 (a flat spectrum radio quasar (FSRQ) at z = 0.361) during its high activity period between 2008 September and 2009 June. During this 11 month period, the source was characterized by a complex variability at optical, UV, and gamma-ray bands, on timescales down to 6-12 hr. The brightest gamma-ray isotropic luminosity, recorded on 2009 Ma
Despite our fine-grain anatomical knowledge of the cerebellar cortex, electrophysiological studies of circuit information processing over the last fifty years have been hampered by the difficulty of reliably assigning signals to identified cell types. We approached this problem by assessing the spontaneous activity signatures of identified cerebellar cortical neurones. A range of statistics descri
Popular Abstract in Swedish Graviditetsdiabetes (GDM) innebär att förhöjd glukosnivå i blodet (blodsocker) upptäckts hos en kvinna när hon är gravid. GDM behandlas med anpassad kost, fysisk aktivitet, och när det behövs även insulin, vilket tillsammans har visats motverka de ökade riskerna vid graviditet och förlossning för mamma och barn. Glukosnivåerna normaliseras nästan alltid efter förlossninBackground: Gestational diabetes mellitus (GDM) is associated with risks during pregnancy, during delivery, and in later life with a substantial risk of subsequent diabetes. The worldwide prevalence of GDM is increasing, but varies with differences in diagnostic methods and population characteristics. Results: Capillary glucose concentrations were found to be higher than venous glucose concentrat
Context. Metal-rich globular clusters provide important tracers of the formation of our Galaxy. Moreover, and not less important, they are very important calibrators for the derivation of properties of extra-galactic metal-rich stellar populations. Nonetheless, only a few of the metal-rich globular clusters in the Milky Way have been studied using high-resolution stellar spectra to derive elementa
Estimates of relevant source area of pollen (RSAP) and relative pollen productivity (PPE) are critical parameters for quantitative reconstructions of past vegetation and land cover. This study provides estimates for PPE relative to Poaceae for ten taxa, characterizing the cultural landscape of south Estonia and the RSAP for 40 lakes with an average radius of approximately 100 m (22-274 m, average
We study Hamming versions of two classical clustering problems. The Hamming radius p-clustering problem (HRC) for a set S of k binary strings, each of length n, is to find p binary strings of length n that minimize the maximum Hamming distance between a string in S and the closest of the p strings; this minimum value is termed the p-radius of S and is denoted by varrho. The related Hamming diamete
The world production of paper and paperboard products, which increased 3.3% per year since 1980, reached 243 million tonnes in 1991 and is expected to continue to grow by about 2.5% per year over the next decade. Consumption levels in 1990 ranged from 2.8 kg per capita in India to 313 kg per capita in the United States. The biggest producers of pulp are the United States, Canada and the Scandinavi
BACKGROUND: Exposure to inorganic arsenic (iAs) through drinking water causes cancer. Alterations in mitochondrial DNA copy number (mtDNAcn) and telomere length in blood have been associated with cancer risk. We elucidated if arsenic exposure alters mtDNAcn and telomere length in individuals with different arsenic metabolizing capacity.METHODS: We studied two groups in the Salta province, Argentin
BACKGROUND: The immune system is a promising therapeutic target for disease modification in Parkinson's disease (PD), but appropriate immune-related biomarkers must be identified to allow patient stratification for trials and tracking of therapeutic effects. The objective of this study was to investigate whether immune markers in peripheral blood are candidate prognostic biomarkers through determi
Currently I am studying the realization of two large-scale experimental natural science facilities: The European Spallation Source (ESS) and MAX IV (a synchrotron facility). They are examples of New Big Science (NBS) – facilities where substantial amounts of resources and hopes are tied to making future scientific discoveries. Both facilities will host more than 20 different instruments, catering Feminist technoscience studies (FTS) comprise a major strand of STS. Constituted by a diverse and heterogeneous set of projects and publications, these studies make politicised, impassioned contributions to contemporary critical thought about science, technology and medicine. They are also driven by a powerful desire for justice (see Reardon et al in Catalyst Vol 1 No 1). Building on century-old t
An oak forest and three wet meadows/fens were reinvestigated after 50 years concerning tree vitality, biomass and productivity, and soil chemistry. Sulphur and nitrogen deposition has changed dramatically during these years, and the aim was to analyse the differences in both the oak forest and the open field ecosystems. Trees were re-measured and soil profiles were resampled. Important visible cha
Background Sun exposure in combination with skin pigmentation is the main determinant for vitamin D status. Human skin color seems to be adapted and optimized for regional sun ultraviolet (UV) intensity. However, we do not know if fair, UV-sensitive skin is a survival advantage in regions with low UV radiation. Methods A population-based nested case-control study of 29,518 Caucasian women, ages 25
This paper evaluates the low-cost optical sensor OPC-N3 from Alphasense as a suitable scientific instrument for measuring particulate matter levels in air, both outdoors and in- doors. The time-keeping and data-retrieval was additionally improved by connecting the OPC-N3 to an Arduino microcontroller equipped with a real-time clock (RTC) module and an external SD card. Inter-comparison tests demon
Hjärttransplantationer syftar till att rädda liv men kan även vara riskabla ingrepp. Det är mycket som kan gå fel. Det transplanterade hjärtat lider stor risk att avstötas i mottagarens kropp, och en mer detaljerad kunskap om faktorerna som påverkar avstötning har således möjligheten att rädda liv. Avstötning orsakas av att mottagarens immunförsvar känner av HLA-molekylerna, där HLA står för HumThe beneficial effects of HLA matching at the HLA-A, -B and -DR loci on recipient short- and long-term survival in heart transplants have been established in a number of studies. The objective of the present study was to evaluate the importance of individual HLA alleles at the HLA-A, -B and -DR loci as risk factors for recipient death within one year after transplant by using artificial neural net
This study aims to deduce what Japanese native speakers think of the Japanese writing systems, and in particular what native speakers’ opinions are concerning Kanji, the logographic writing system which consists of Chinese characters. The Japanese written language has something that most languages do not; namely a total of three writing systems. First, there is the Kana writing system, which cons
Sveriges geologiska undersökning (SGU) har ägnat flera år åt att undersöka den svenska berggrunden för att utreda möjligheterna för geologisk lagring av koldioxid. Djupt liggande akviferer anses ha störst potential och den kambriska Faluddensandstenen, som finns i Östersjön öster om Gotland, visar stor potential som lagringsakvifer. I denna studie har borrkärnan St. Sutarve-2018 från södra GotlandThe Geological Survey of Sweden (SGU) has spent several years investigating the Swedish bedrock to find suitable bedrock for geological storage of carbon dioxide. Deep saline aquifers are considered to have the greatest potential, and the Cambrian Faludden Sandstone subcropping in the Baltic Sea east of Gotland, shows great potential as a storage aquifer. In this study, the drill core St. Sutarve
Our aim was to identify serum microRNAs (miRNAs) in healthy humans which associate with future onset of both diabetes mellitus and cardiovascular disease. We performed global profiling of 753 mature human miRNAs in serum of 12 pilot subjects followed by measurement of 47 consistently expressed miRNAs in fasting serum of 553 healthy subjects from the baseline exam (1991–1994) of the population base
Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations
