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Analysis of the molecular interplay between Streptococcus pyogenes and its human host

The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. pyogenes infections, human plasma leaks into the site of infection as a consequence of infl

Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein.

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhib

Derivation of efficiency factors for uneven irradiation on a fin absorber

In the equation for thermal energy output from a flat-plate solar collector (written as a function of the collector mean heat carrier temperature), both the gain and the loss terms are multiplied by the collector efficiency factor, F'. For a concentrating collector with an uneven (non-uniform) irradiation on the absorber, the efficiency factor for the gain term, here called the optical efficiency

Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy

Popular Abstract in Swedish Hur gör bakterier för att komma undan immunförsvaret? Vi har studerat hur en vanligt förekommande bakterie, grupp A streptokocker, gör för att undvika kroppens immunförsvar vid infektion. Vi har upptäckt enzymer som bidrar till bakteriens förmåga att undvika immunförsvaret genom att avväpna antikroppar. De bakteriella enzymerna kan användas i bioteknisk industri och eveA majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring bacterial modulation of host glycosylation in infection and to evaluate the usefulness of bacterial enzymes i

Eosinophil granulocyte interaction with serum-opsonized particles: binding and degranulation are enhanced by tumor necrosis factor alpha

Eosinophils participate in the inflammatory response seen in allergy and helminthic infestation. Their release of granule-bound cationic proteins may play a role in these diseases. Therefore, we investigated mechanisms involved in the release of eosinophil cationic protein (ECP). Serum-opsonized zymosan was phagocytosed by eosinophils, and ECP was released into the phagosomes as judged by immunoel

Two major classes in the M protein family in group A streptococci

The M protein family of molecules in the group A streptococcus comprises a number of cell surface proteins that interact with the immune system of the host. One of the proteins in this family is the IgA receptor Arp4, which has C repeats similar to those that characterize the known M proteins. The streptococcal strain expressing Arp4 also expresses a second immunoglobulin-binding protein, Mrp4, wh

New treatments in hemophilia: insights for the clinician.

Hemophilia has evolved from an often fatal hereditary bleeding disorder to a disorder for which safe and effective treatment is available. However, there are several challenges remaining in the treatment of hemophilia. Prophylaxis to prevent bleeding is costly and requires frequent intravenous injections, which are cumbersome for patients. Venous access is often difficult to achieve, especially in

The PreAmplifier ShAper for the ALICE TPC detector

In this paper the PreAmplifier ShAper (PASA) for the Time Projection Chamber (TPC) of the ALICE experiment at LHC is presented. The ALICE TPC PASA is an ASIC that integrates 16 identical channels, each consisting of Charge Sensitive Amplifiers (CSA) followed by a Pole-Zero network, self-adaptive bias network, two second-order bridged-T filters, two non-inverting level shifters and a start-up circu

Genetic control of collagen-induced arthritis in a cross with NOD and C57Bl/10 mice is dependent on gene regions coding for complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes.

The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren′s syndrome. To investigate whether NOD genes also promote autoimmune-mediatedarthritis we established a NOD strain with an MHC class II fragment containing the Aq class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contr

The 5 ' Region of the MSH2 gene involved in hereditary non-polyposis colorectal cancer contains a high density of recombinogenic sequences

MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion

2010: Finished PhD projects

Human Ecology DivisionCarl Nordlund     "Social Ecography; International trade, network analysis, and an Emmanuelian conceptualization of ecological unequal exchange"Presentation: Defence date: 11th October 2010. This thesis demonstrates how network analysis, ecological economics and the world-system perspective can be combined into an ecographic framework that can yield new insights into the unde

https://www.keg.lu.se/en/research/research-projects/finished-phd-projects/2010-finished-phd-projects - 2026-05-29

MVES04 Schema 2021 210219

Nytt Schema Centrum för miljö- och klimatforskning, CEC, Miljövetenskaplig Utbildning, Sölvegatan 37, 223 62 Lund http://www.miljovetenskap.lu.se/ Preliminärt Schema MVES04 - Miljöövervakning, 15p VT21 Kurstid: 24 mars - 31 maj maj Kurschef: Adam Kristensson, tel:046-2227645, email: adam.kristensson@nuclear.lu.se Yann Clough, tel: 046-2226831, email: yann.clough@cec.lu.se Lärare: Namn Email AKR Ad

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/2021-02/MVES04_Schema%202021_210219.xlsx - 2026-05-31

Ana Rebordão

Sometimes it ends with a kiss Ana Rebordão creates staged environments in which she always plays the central figure, shifting between roles. Her latest piece, Sometimes it ends with a kiss, reflects on power relations within family structures. Through absurd, enigmatic performances, she evokes a sense of trauma and gives a sharp voice to silent female characters. The work shows women speaking to t

https://www.iac.lu.se/ana-rebordao - 2026-05-29

No title

https://goteborgonline-my.sharepoint.com/personal/peter_jonsson_educ_goteborg_se/Documents/C%20e%20n%20t%20r%20a%20l%20a%20%20%20S%20a%20c%20o%20r%20å%20d%20e%20t%20%20%20i%20%20%20G%20ö%20t%20e%20b%20o%20r%20g%20s%20%20%20S%20t%20a%20d/AU/SKOT/C%20E%20N%20T%20R%20A%20L%20A%20%20%20S%20A%20C%20O%20R%20Å%20D%20E%20T%20%20%20I%20N%20F%20O%20R%20M%20E%20R%20A%20R/December%202024/www.saco.se/goteborg

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/goteborgs-stad/dokument/centrala-sacoradet-informerar/april-2025_centrala-sacoradet-informerar.pdf - 2026-05-31

1997cv cesilia sterner

contact@ceciliasterner.com www.ceciliasterner.com +46-707-516207 2001 Publikation #14, Rollon, Malmö 2000 Gallery C. Hjärne, Helsingborg 2000 Shoot- Moving Pictures by Artists, biograf Spegeln, Malmö 2000 Aura, Krognoshuset i Lund 1999 Rollon, www.rollon.net 1999 South City Drawings, The Pineapple 1999 Rollon, Panora, Malmö 1999 Whiteout Greyout Blackout, Barbacka konsthall, Kristianstad 1997 Mike

https://www.khm.lu.se/sites/khm.lu.se/files/1997cv_cesilia_sterner.pdf - 2026-05-31