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Here we report a case of an 11-year-old girl with an inoperable tumor in the optic chiasm/hypothalamus, who experienced several tumor progressions despite three lines of chemotherapy treatment. Routine clinical examination classified the tumor as a BRAF-negative pilocytic astrocytoma. Copy-number variation profiling of fresh frozen tumor material identified two duplications in 9q21.32-33 leading t
Body dysmorphic disorder (BDD) is a prevalent and impairing psychiatric condition that typically debuts in adolescence and is associated with risky behaviours. The disorder can be effectively treated with cognitive behaviour therapy (CBT). However, CBT for BDD is seldom available primarily due to a shortage of trained therapists. Internet-delivered CBT (ICBT) can be a way to increase treatment ava
This short report is one of a series of outputs to flow from the international,interdisciplinary project ‘Looking back to move forwards: a social and cultural historyof home heating’ (JUSTHEAT), funded through the Collaboration of Humanities andSocial Sciences in Europe (CHANSE) initiative, which began in 2022 and runs until2025. Within this project, we aim to understand how major changes to home
Neonicotinoids, systemic insecticides that are distributed into all plant tissues and protect against pests, have become a common part of crop production, but can unintentionally also affect non-target organisms, including pollinators. Such effects can be direct effects from insecticide exposure, but neonicotinoids can affect plant physiology, and effects could therefore also be indirectly mediate
Background: Body dysmorphic disorder (BDD) is thought to be associated with considerable suicide risk. This nationwide cohort study quantified the risks of intentional self-harm—including nonsuicidal self-injuries and suicide attempts—and death by suicide in BDD. Methods: Individuals with a validated ICD-10 diagnosis of BDD in the Swedish National Patient Register, registered between January 1, 19
Popular Abstract in Swedish Den mänskliga kroppen är ett komplext maskineri med en rad olika reglersystem och kontrollmekanismer. Flera grenar av modern biomedicinsk forskning riktar sig mot olika nivåer av detta komplexa maskineri. En av dessa grenar heter genomik, som ärläran om hur den genetiska koden som finns i varenda cell av en organism används och regleras. Slutförandet av Human Genome ProAs the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. It is then no surprise that proteomics is a field full of promise, one which is expected to generate significant insights towards fu
A mid-century net zero target creates a challenge for reducing the emissions of emissions-intensive, trade-exposed sectors with high cost mitigation options. These sectors include aluminium, cement, chemicals, iron and steel, lime, pulp and paper and petroleum refining. Available studies agree that decarbonization of these sectors is possible by mid-century if more ambitious policies are implement
Background and aims: The gastric hormone ghrelin has been reported to stimulate food intake, increase weight gain, and cause obesity but its precise physiological role remains unclear. We investigated the long term effects of gastrectomy evoked ghrelin deficiency and of daily ghrelin injections on daily food intake, body weight, fat mass, lean body mass, and bone mass in mice. Methods: Ghrelin wa
Popular Abstract in Swedish I många utvecklingsländer i tropiska klimat leder den snabba urbaniseringen till många problem, bl a försämrad termisk komfort i utemiljön. Detta har negativa följder för människors hälsa och välbefinnande och påverkar sociala och kommersiella aktiviteter utomhus negativt. Följaktligen är det mycket viktigt att åstadkomma komfortabla mikroklimat i urban miljö. Den huvuIn many developing tropical countries, rapid urban growth leads to several problems, including increased thermal stress. This has negative consequences for people's health and well-being, and affects social and commercial outdoor activities negatively. Consequently, the creation of thermally comfortable microclimates in urban environments is highly important. The main aim of this thesis is to dee
In addition to proton-pumping complex I, the plant respiratory chain contains type II NAD(P)H dehydrogenases. These extra enzymes do not pump protons and consequently do not contribute to the electrochemical proton gradient. Database screening of the Arabidopsis genome identified seven type II NAD(P)H dehydrogenase homologues of which two and four genes were closely related to potato (Solanum tube
This manuscript presents the digital hardware realization of a wavelet based event detector for cardiac pacemaker applications. The architecture of the detector is partially folded to minimize hardware cost. An energy model is applied to evaluate the energy efficiency the sub-threshold (sub-VT ) domain. The design is synthesized in 65nm low leakage-high threshold CMOS technology, and it is shown t
The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo
Popular Abstract in Swedish Datorgenererade bilder är en viktig del av underhållningsindustrin, som bland annat innefattar spel- och filmindustrin. För att kunna skapa avancerade specialeffekter i filmer samt stora och detaljerade spelvärldar krävs datorprogram som utnyttjar beräkningskraften i dagens datorer på ett effektivt sätt. Bättre och snabbare datorprogram leder ofta till nya användaruppleComputer generated imagery is vital to the entertainment industry in the production of games and films, for example. It is also increasingly important for visualization in design, architecture, engineering, and medicine, to name a few. Improvements to rendering techniques come from a combination of improved algorithms and more powerful hardware. Typically, hardware developments introduce new chall
Rapporten redovisar resultatet från en utrymningsövning som genomfördes från ett 8-vagnars tunnelbanetåg som stannat i en tunnel. Orsaken till att tåget stannat skulle vara brand i tåget eller i tunneln. Försöket genomfördes en natt mellan den 20 och 21 maj 1999 i tunnelbanan i Stockholm. Platsen för försöket var mellan stationerna Stadion och Östermalms torg. Totalt medverkade 143 försökspersoner
Body dysmorphic disorder (BDD) often starts in childhood, with most cases developing symptoms before age 18. Yet, BDD research has primarily focused on adults. We report the clinical characteristics of the world’s largest cohort of carefully diagnosed youths with BDD and focus on previously unexplored sex and age differences. We systematically collected clinical data from 172 young people with BDD
Background: Treatment guidelines recommend behaviour therapy (BT) for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). However, BT is rarely accessible due to limited availability of trained therapists and long travel distances to specialist clinics. Internet-delivered BT has the potential of overcoming these barriers through remote delivery of treatment with minimal therapist
This thesis project explores the significance of public spaces in shaping society, culture, and individual identity, emphasizing their role in promoting democratic values and self-realization. Public spaces, such as squares and marketplaces, serve as platforms for social interaction, economic activity, and cultural continuity. The design of these spaces reflects societal values and historical cont
Den 1 januari 2016 skärptes kraven för luftutsläpp från förbränningsanläggningar genom För-ordningen (2013:252) om stora förbränningsanläggningar. I förordningen skärptes bland annat kraven för utsläpp av kväveoxider, NOX. Till följd av de skärpta kraven berördes Kraftringens produktionsanläggning Gunnesboverket. På anläggningen finns tre biooljeeldade hetvatten-pannor för fjärrvärmeproduktion därNew regulations regarding emissions of air pollutants came into force as of January 1st 2016 in Sweden. The regulations are found in “The Regulation on Large Combustion Plants” SFS 2013:252. The regulation contained stricter regulations of NOX emissions which affected the energy company Kraftringen and their three biooil-fueled boilers, at the heating plant Gunnesboverket, that are used for produc
The response rate to checkpoint inhibitors for women with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum (HGSC) is modest, and development of predictive biomarkers is needed. The main focus has been on tumor cell PD-L1 expression, but its assessment alone is insufficient for patient selection in most malignancies. We mapped the presence of macrophages (CD68 and CD163) and
