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Release properties of intrahippocampal transplants of noradrenergic neurons were monitored by microdialysis in awake and halothane-anaesthetized rats. Fetal locus coeruleus neurons were implanted as a cell suspension into hippocampi deprived of their innate noradrenalin (NA) innervation by intraventricular 6-hydroxydopamine treatment. Dialysis probes of the loop type were implanted into the dorsal
In a critique of the sometimes confusing ways in which the term transnational has been repeatedly used, Mette Hjort, in 2010 attempted to outline what she called a “typology of transnationalisms” in connection with contemporary audio-visual production (2009: 12–33). Hjort’s palpable purpose here is to more specifically illuminate and contextualize the increasingly more used concept of transnationa
The dissertation can be divided into two parts, the first of which is a detailed analysis of three excavations concerning Mellanbyn in southern Malmö. In the second part I study the more general development of society, relating Mellanbyn to the surrounding area as well as to the region as a whole during Late Bronze Age and the Early Iron Age. The aim can be summed up as being to study the developm
My thesis is part of an overall environmental program evaluating the environmental and human health stress in areas of Nicaragua affected by anthropogenic emission of metals and man-made organic substances. I examine the fluvial transport of mercury contextually associated with the extent of the contamination and the observed human and environmental stress in a gold mining area. Field measurements
Popular Abstract in Swedish Evolusjon og energikonservering i en katalysator i cellens kraftverk Alle levende organismer må omforme energien i mat eller sollys til en form som cellen kan bruke som energi. Energien brukes både til prosesser som bryter ned og bygger opp komponenter i cellen. Den brukes også til prosesser som muskelsammentrekninger, celledelinger og bevegelser. Uansett hva slags cel
Chancroid caused by Haemophilus ducreyi, has been described as a significantly predisposing factor of HIV heterosexual transmission in an endemic region of both diseases. Antibiotic resistances are extensively found in H. ducreyi and many of the resistances are due to the presence of resistance plasmids. A high tendency of drug resistances has commonly been found among isolates derived in Thailan
Popular Abstract in English All living things somehow communicate with each other. Cell-to-cell communication, or signalling, occurs on the molecular level, regulating the body’s activities and coordinating various cell actions and is thereby valuable for realizing cell as well as system functions. Errors in the cellular transferred information may induce diseases such as cancer and autoimmune disGlypicans are multifunctional cell surface heparan sulphate proteoglycans co-regulating numerous signalling pathways, and are thereby involved in the control of cellular division, differentiation, and morphogenesis. The heparan sulphate (HS) chains are responsible for many of those biological functions; nevertheless recent studies suggest functional roles for the glypican core proteins in mediatin
Popular Abstract in Swedish De generella företeelser som sker i samband med en axonal skada i det perifera nervsystemet (PNS) har tidigare beskrivits i detalj. Däremot är de molekylära mekanismer som ligger bakom celldöd, eller bakom nervcellens förmåga att regenerera efter en axonal skada, ringa studerade. Den här avhandlingen behandlar en sådan molekylär mekanism, JNK-medierad aktivering av c-JuThe events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. This thesis concerns one such molecular mechanism, JNK-mediated c-Jun activation, in peripheral sensory and sympathetic neurons. By immunohistoche
Popular Abstract in Swedish Det finns många skäl till varför streptomyceter är en intressant grupp av bakterier att undersöka. Den här avhandlingen fokuserar på celldifferentieringen hos dessa organismer och deras förmåga att bilda en specialiserad typ av tåliga celler som kallas sporer. Genom att studera sporuleringsprocessen hos dessa bakterier kan man lära sig mycket om fundamentala livsprocessStreptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i
We present a synthesis of the results of a multiproxy, multisite, palaeoecological study of Holocene environmental change in Kamchatka, Far East Russia, details of which are presented elsewhere in the volume. We summarise the results of the analyses of pollen, diatom, chironomid, and testate amoebae assemblages, together with stable isotopes of oxygen and carbon, and sediment characteristics from
Abstract Fatty acids mobilized from triacylglycerol stores are a major energy source in humans. Mobilization occurs through the consecutive action of three lipases: adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). Whereas ATGL and MGL only hydrolyse tri- and monoacylglycerols, respectively, HSL has a broad substrate range and hydrolyses cholesterol
Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli
Methods have been studied for the production of chiral alcohols, which are of importance in organic synthesis of pharmaceuticals, agro-chemicals and fragrances, etc., through the enzymatic or microbial reduction of ketones. Classical reaction engineering was combined with genetic engineering to improve the production of chiral alcohols and kinetic resolution of racemic ketones with high enantiomer
BACKGROUND: Gonadotropin-releasing hormone (GnRH) antagonists have been reported to have beneficial effects on lower urinary tract symptoms in patients with benign prostatic hyperplasia. OBJECTIVE: Our aim was to investigate the effects of ganirelix, a GnRH receptor antagonist, on bladder function and detrusor overactivity (DO) in female rats. DESIGN, SETTING, AND PARTICIPANTS: Female Sprague-Dawl
The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. Several Q compounds have reached clinical trials and one compound, laquinimod, is currently in phase III clinical trial for relapsing-remitting multiple sclerosis. The Q
The aim of this study is to extend the traffic safety assessment concept to also include normal road user behaviour, thus not only exceptional behaviours such as accidents and serious conflicts. The goal is to provide a framework for a more thorough description and analysis of safety related road user behaviour in order to better understand the traffic safety processes. The traffic safety process
