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The effect of strain and transforming growth factor beta on equine tendon fibroblasts (tenocytes) was assessed in vitro. Tenocytes were isolated from flexor and extensor tendons of horses from foetal to 10 years of age. These cells were cultured until confluent on collagen-coated silicone dishes. Cyclic biaxial strain of 9 +/- 1% was applied at 0.5 Hz for 24 hours with or without added TGFbeta1 or
Each autumn, large numbers of red admirals migrate throughout northern Europe,flying south, to reach areas with conditions suitable for surviving the winter. We observed the visible butterfly migration at Falsterbo peninsula, the southwesternmost point in Sweden, where red admirals are seen most autumns. ying towards the Danish coast on their way to more southern parts of Europe. Weather parameter
-Reduced arterial compliance precedes changes in blood pressure, which may be mediated through alterations in vessel wall matrix composition. We investigated the effect of the collagen type I-alpha1 gene (COL1A1) +2046G>T polymorphism on arterial compliance in healthy individuals. We recruited 489 subjects (251 men and 238 women; mean age, 22.6+/-1.6 years). COL1A1 genotypes were determined using
Unhealthful lifestyles underpin much of the burden of cardiometabolic disease affecting contemporary societies. Our overarching objective is to discover and optimise measurable biomarkers that can be used to stratify patient populations into subgroups that can be treated more effectively with targeted lifestyle therapies, at lesser cost and with fewer adverse events than conventional approaches
Environmental psychology conducts research, teaching and collaborations focused on the interaction between people and the environment from the perspective of the individual. The subject deals with how people experience their surroundings and are affected by them, as well as how humans affect the environment through their behaviour. The research encompasses the relationship to both the physical a
Bakteriella infektioner är ett stort globalt hälsoproblem och mer detaljerad kunskap om värd-bakterieinteraktioner är nödvändiga för att kunna bemöta den ökande antibiotikaresistensen. Nordenfelt-labbet använder unik biosensorteknologi tillsammans med avancerad videomikroskopi och bildanalystekniker för att studera tidiga värd-bakterieinteraktioner. Den molekylära sammansättningen av bakterier ochBacterial infections represent a major global health issue and more detailed knowledge about host-bacteria interactions are needed to counteract the rising bacterial resistance to antibiotics. The Nordenfelt Lab uses unique biosensor technology in conjunction with advanced live imaging and image analysis techniques to study initial host-pathogen interactions. The molecular surface composition of
In 2018, the Irish public voted to repeal the Eighth Amendment to the Irish Constitution, which since 1983 banned abortion in the country. While this was a watershed moment in Irish history, it was not unconnected to wider discussions now taking place around the world concerning gender, reproductive rights, the future of religion, Church–State relationships, democracy and social movements. With th
Humanistiska och teologiska fakulteterna bedriver en bred och varierad verksamhet inom forskning och utbildning som i vid mening syftar till att förstå människan som kulturell och samhällelig varelse. Vi forskar och utbildar inom områden som behandlar kulturmöten, språk, historia, etik, religion, filosofi, konst, musik, litteratur och annat som formar och definierar kulturerna.The Joint Faculties of Humanities and Theology provide research and education in a broad range of subjects, ranging from cultural sciences, history, philosophy, archaeology, languages and literature to theology and religious studies.
We study the adjoint of the double layer potential associated with the Laplacian (the adjoint of the Neumann-Poincaré operator), as a map on the boundary surface Γ of a domain in R3 with conical points. The spectrum of this operator directly reflects the well-posedness of related transmission problems across Γ. In particular, if the domain is understood as an inclusion with complex permittivity ε,
Övergripande målet för vår forskning är att undersöka hur miljöfaktorer associerade med utveckling av typ 2-diabetes (T2D) påverkar frisättning av insulin och glukagon från bukspottkörtelns Langerhanska öar. Insulin och glukagon reglerar reciprokt blodets glukosnivåer. Insulin minskar blodglukoskoncentrationer efter måltid, glukagon medverkar till ökade nivåer av glukos vid fasta och ansträngn. ViThe overall objective of our research is to investigate how Type 2 Diabetes (T2D) associated environmental factors effects the islet hormone secretion with a specific focus on how impaired exocytosis is involved in the etiology of the disease. We investigate from a cell physiological perspective the regulation of insulin and glucagon secretion from the pancreatic beta – and alpha cells, respective
En stor del av diabetesforskningen vid Lunds universitet görs inom forskningsmiljön EXODIAB som är ett strategiskt forskningsområde (SFO) i Sverige. Inom EXODIAB har Lunds universitets diabetescentrum (LUDC) och Uppsala universitet ett nära samarbete.A significant part of diabetes research at Lund University is conducted within EXODIAB, which is a strategic research area (SRA) in Sweden. Within EXODIAB, Lund University Diabetes Centre (LUDC) and Uppsala University work closely together.
We are striving towards the identification of disease-modifying mechanisms that protect endogenous insulin release and diabetes development. Ion channels play overarching roles as sensors of cellular activity and control long-term adaptation of the endocrine pancreatic islet to the environmental demands. Our goals concern signals involved in cellular responses to beta-cell overload: 1)Role of vol
